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公开(公告)号：US20070021483A1
公开(公告)日：2007-01-25
申请号：US11335171
申请日：2006-01-19
申请人： Robert Chalifour , Xianqi Kong , Xinfu Wu , Wenshuo Lu
发明人： Robert Chalifour , Xianqi Kong , Xinfu Wu , Wenshuo Lu
IPC分类号： A61K31/4184 , A61K31/155 , C07D403/02 , C07C257/12
CPC分类号： C07C257/18 , A61K31/155 , A61K31/341 , A61K31/343 , A61K31/4164 , A61K31/4184 , Y02P20/582
摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:
摘要翻译： 本发明涉及脒化合物在淀粉样蛋白相关疾病的治疗中的应用。 特别地，本发明涉及治疗或预防受试者中淀粉样蛋白相关疾病的方法，其包括向受试者施用治疗量的脒化合物。 根据本发明使用的化合物是根据下式的那些，使得当给药时，降低或抑制淀粉样蛋白原纤维形成，神经变性或细胞毒性：
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2.发明申请Methods and compositions for the treatment of amyloid-and epileptogenesis-associated diseases 审中-公开用于治疗淀粉样蛋白和癫痫发生相关疾病的方法和组合物公开(公告)号：US20050038000A1
公开(公告)日：2005-02-17
申请号：US10871512
申请日：2004-06-18
申请人： Xianqi Kong , Wenshuo Lu , Xinfu Wu
发明人： Xianqi Kong , Wenshuo Lu , Xinfu Wu
IPC分类号： A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/66
CPC分类号： A61K31/4196 , A61K31/121 , A61K31/423 , A61K31/428 , A61K31/66 , C07C309/14 , C07C309/15 , C07C309/18 , C07C309/24 , C07C309/26 , C07C2601/14 , C07C2602/10 , C07D209/08 , C07D213/38 , C07D233/24 , C07D233/28 , C07D239/06 , C07D263/10 , C07D263/16 , C07D265/08 , C07D277/10 , C07D277/12 , C07D279/06 , C07D317/58 , C07D333/20 , C07D333/54
摘要： Methods of treating or preventing an amyloid-related disease in a subject by administering to a subject a therapeutic amount of a compound of the invention are described. Also included are methods for inhibiting epileptogenesis in a subject, by administering to a subject an effective amount of an anti-epileptogenic agent. Methods for treating a subject suffering from an epileptogenesis-associated condition, by administering to the subject an effective amount of an anti-epileptogenic agent are also included. Methods for treating convulsions in a subject by administering to the subject an effective amount of a therapeutic amount of a compound of the invention are also described.
摘要翻译： 描述了通过向受试者施用治疗量的本发明化合物来治疗或预防受试者中淀粉样蛋白相关疾病的方法。 还包括通过向受试者施用有效量的抗癫痫发生剂来抑制受试者中癫痫发生的方法。 还包括通过向受试者施用有效量的抗癫痫发生剂来治疗患有癫痫发生相关病症的受试者的方法。 还描述了通过向受试者施用有效量的治疗量的本发明化合物来治疗受试者惊厥的方法。
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公开(公告)号：US20100113591A1
公开(公告)日：2010-05-06
申请号：US12613412
申请日：2009-11-05
申请人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号： A61K31/27 , C07C309/04 , A61K31/16 , C07C53/00 , A61K31/215 , C07C309/65 , A61K31/165 , A61P25/28 , A61P9/00 , A61P17/00
CPC分类号： C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译： 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。
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公开(公告)号：US07253306B2
公开(公告)日：2007-08-07
申请号：US10871543
申请日：2004-06-18
申请人： Xianqi Kong , David Migneault , Xinfu Wu
发明人： Xianqi Kong , David Migneault , Xinfu Wu
IPC分类号： C07C309/00
CPC分类号： A61K31/185
摘要： The present invention is directed to methods of preparation of sulfonate derivatized compounds, e.g., 3-amino-1-propanesulfonic acid and 1,3-propanedisulfonic acid disodium salt with increased purity, with reduced potential for toxic by-products, and that are pharmaceutically useful, e.g., for the treatment of amyloidosis.
摘要翻译： 本发明涉及制备磺酸衍生化合物的方法，例如3-氨基-1-丙磺酸和1,3-丙烷二磺酸二钠盐，其纯度提高，有毒副产物的潜力降低，且为药学上 有用的，例如用于治疗淀粉样变性。
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公开(公告)号：US20060223855A1
公开(公告)日：2006-10-05
申请号：US11316693
申请日：2005-12-21
申请人： Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
发明人： Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
IPC分类号： A61K31/445 , C07D211/06 , A61K31/185
CPC分类号： C07C309/19 , C07C309/14 , C07C309/21 , C07C309/24 , C07C309/26 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/12 , C07D207/333 , C07D209/08 , C07D209/16 , C07D209/36 , C07D209/44 , C07D209/48 , C07D209/86 , C07D211/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D211/82 , C07D213/04 , C07D213/20 , C07D213/50 , C07D213/75 , C07D213/82 , C07D217/04 , C07D219/10 , C07D231/44 , C07D233/54 , C07D235/28 , C07D257/04 , C07D275/06 , C07D277/66 , C07D295/073 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D327/04 , C07D327/06 , C07D327/08 , C07D333/20 , C07D333/34 , C07D409/04 , C07D471/04 , C07D471/08 , C07K5/06
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译： 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。
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公开(公告)号：US07414076B2
公开(公告)日：2008-08-19
申请号：US10871514
申请日：2004-06-18
申请人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号： A61K31/185 , C07C309/00
CPC分类号： C07D295/084 , C07C307/02 , C07C309/13 , C07C309/14 , C07C309/15 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D295/088 , C07F9/1651 , C07F9/2458
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译： 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。
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公开(公告)号：US07262223B2
公开(公告)日：2007-08-28
申请号：US10763953
申请日：2004-01-23
申请人： Xianqi Kong , Xinfu Wu , David Migneault
发明人： Xianqi Kong , Xinfu Wu , David Migneault
IPC分类号： A61K31/155 , A61K31/4164 , A61K31/166 , A61K31/18 , A61K31/4168
CPC分类号： A61K31/4172 , A61K31/155
摘要： The present invention relates to the use of amidine compounds in the treatment of amyloid-related diseases. In particular, the invention relates to a method of treating or preventing an amyloid-related disease in a subject comprising administering to the subject a therapeutic amount of an amidine compound. Among the compounds for use according to the invention are those according to the following Formula, such that, when administered, amyloid fibril formation, neurodegeneration, or cellular toxicity is reduced or inhibited:
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公开(公告)号：US20140329746A1
公开(公告)日：2014-11-06
申请号：US14332675
申请日：2014-07-16
申请人： Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
发明人： Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
IPC分类号： C07C309/19 , C07D211/64 , C07D211/52 , C07K5/06 , C07D213/50 , C07D295/088 , C07D211/70 , C07C309/24 , C07D211/14 , C07D213/04
CPC分类号： C07C309/19 , C07C309/14 , C07C309/21 , C07C309/24 , C07C309/26 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/12 , C07D207/333 , C07D209/08 , C07D209/16 , C07D209/36 , C07D209/44 , C07D209/48 , C07D209/86 , C07D211/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D211/82 , C07D213/04 , C07D213/20 , C07D213/50 , C07D213/75 , C07D213/82 , C07D217/04 , C07D219/10 , C07D231/44 , C07D233/54 , C07D235/28 , C07D257/04 , C07D275/06 , C07D277/66 , C07D295/073 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D327/04 , C07D327/06 , C07D327/08 , C07D333/20 , C07D333/34 , C07D409/04 , C07D471/04 , C07D471/08 , C07K5/06
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
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公开(公告)号：US20140107027A1
公开(公告)日：2014-04-17
申请号：US14132898
申请日：2013-12-18
申请人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号： C07C309/14 , C07K5/087 , C07D453/02 , C07D295/088 , C07D209/18 , C07D257/04
CPC分类号： C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译： 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。
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公开(公告)号：US08642801B2
公开(公告)日：2014-02-04
申请号：US12613412
申请日：2009-11-05
申请人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人： Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号： C07C309/19 , A61K31/185
CPC分类号： C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要： Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译： 描述了治疗或预防淀粉样蛋白相关疾病的方法，化合物，药物组合物和试剂盒。
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