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公开(公告)号：US20200003666A1
公开(公告)日：2020-01-02
申请号：US16569700
申请日：2019-09-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Eloisa Lopez-Calle , Ewelina Hegel , Thomas Fischer , Caroline Bylda , Hans-Peter Josel , Josef Roedl
Abstract: The present disclosure relates to an in vitro method for releasing analytes from a sample involving contacting the sample with (i) a chaotropic agent, (ii) an organic solvent, (iii) a detergent, and (iv) at least one agent providing bicarbonate ions. The present disclosure further relates to a release agent for releasing analytes from a sample having the aforesaid compounds. Moreover, the present disclosure relates to uses, kits, methods and devices related to the method and the release agent of the present disclosure.
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公开(公告)号：US10132805B2
公开(公告)日：2018-11-20
申请号：US14524700
申请日：2014-10-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Georg Kurz , Eloisa Lopez-Calle
IPC: G01N31/00 , G01N33/53 , G01N33/543 , G01N21/27 , G01N33/52 , G01N21/78 , G01N21/82 , G01D18/00 , G01N21/63 , G01N33/573 , G01N33/68 , G01N33/92 , G06F19/18 , G16H50/30
Abstract: A method for determining the amount of specific analyte of a sample which may show interferences by photometric assays, wherein the analyte is quantified from the change in the optical signal of the reaction mixture after the interaction of the analyte with analyte specific reagents. Multiple calibration curves are generated for multiple wavelengths for the specific analyte. An interference test is performed simultaneously to the determination of the specific analyte, for quantifying the amount of interfering substances present in the sample. The amount of each interfering substances is compared to predetermined cut-off values. The optical signal for the specific analyte is measured in the reaction mixture at multiple wavelengths over the complete reaction time, and a calibration curve is selected depending on the interfering substances. The amount of specific analyte is quantified by comparison with the selected calibration curve for the chosen wavelengths.
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3.发明申请SENSITIVITY AND THE DYNAMIC RANGE OF PHOTOMETRIC ASSAYS BY GENERATING MULTIPLE CALIBRATION CURVES 审中-公开通过产生多个校准曲线的灵敏度和光学测量的动态范围公开(公告)号：US20150046114A1
公开(公告)日：2015-02-12
申请号：US14524633
申请日：2014-10-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thornsten Brueckner , Eloisa Lopez-Calle , Norbert Oranth , Josef Roedl
IPC: G01N33/92 , G06F19/18 , G01N21/63 , G01N33/573 , G01N33/68
CPC classification number: G01N33/54393 , G01D18/00 , G01N21/274 , G01N21/63 , G01N21/78 , G01N21/82 , G01N33/52 , G01N33/54313 , G01N33/54346 , G01N33/573 , G01N33/6827 , G01N33/92 , G01N2021/825 , G16B20/00 , G16H50/30 , Y02A90/26
Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.
Abstract translation: 用于通过光度测定法确定特定分析物的量的方法，其中样品中的特定分析物与反应混合物中的分析物特异性反应伴侣反应。 产生至少两个校准曲线，针对低浓度的特定分析物优化以第一波长记录的第一校准曲线，从而使检测下限最大化，并且以第二波长记录的第二校准曲线被优化用于高浓度 特异性分析物，从而最大化上限检测限。 优化的较低检测限和优化的上限检测极限导致扩展的动态范围。
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公开(公告)号：US08772486B2
公开(公告)日：2014-07-08
申请号：US13961381
申请日：2013-08-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Cysewski , Luisa de Cola , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Eloisa Lopez-Calle , Toralf Zarnt
IPC: C07F15/00
CPC classification number: G01N33/53 , C07F15/0033 , G01N33/582
Abstract: Novel iridium-based Ir (III) luminescent complexes, conjugates comprising these complexes as a label and their application, for example in electrochemiluminescence based detection of an analyte.
Abstract translation: 新型铱基Ir（III）发光复合物，包含这些络合物作为标记的共轭物及其应用，例如在基于电化学发光的检测分析物中。
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公开(公告)号：US12194466B2
公开(公告)日：2025-01-14
申请号：US17229086
申请日：2021-04-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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Patent Agency Ranking
公开(公告)号：US11000848B2
公开(公告)日：2021-05-11
申请号：US15982009
申请日：2018-05-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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公开(公告)号：US20190079045A1
公开(公告)日：2019-03-14
申请号：US16185210
申请日：2018-11-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Uwe Goebbert , Eloisa Lopez-Calle , Michael Marquant , Christine Nortmeyer , Katja Reiter , Reiner Stein
IPC: G01N27/327 , G01N21/78 , B01L3/00
Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.
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8.发明申请公开(公告)号：US20180231544A1
公开(公告)日：2018-08-16
申请号：US15951536
申请日：2018-04-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Eloisa Lopez-Calle , Norbert Oranth , Josef Roedl
IPC: G01N33/543 , G01N33/573 , G01D18/00 , G16H50/30 , G06F19/18 , G01N21/78 , G01N33/52 , G01N21/63 , G01N33/92 , G01N21/27 , G01N21/82 , G01N33/68
CPC classification number: G01N33/54393 , G01D18/00 , G01N21/274 , G01N21/63 , G01N21/78 , G01N21/82 , G01N33/52 , G01N33/54313 , G01N33/54346 , G01N33/573 , G01N33/6827 , G01N33/92 , G01N2021/825 , G06F19/18 , G16H50/30 , Y02A90/26
Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.
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公开(公告)号：US08835637B2
公开(公告)日：2014-09-16
申请号：US13961401
申请日：2013-08-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Cysewski , Luisa de Cola , Jesus Miguel Fernandez Hernandez , Hans-Peter Josel , Eloisa Lopez-Calle , Toralf Zarnt
IPC: C07F15/00 , G01N33/533
CPC classification number: C07F15/0033 , G01N21/76 , G01N33/533 , G01N33/582 , G01N2458/30
Abstract: Novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, for example in the electrochemiluminescence based detection of an analyte.
Abstract translation: 新型铱基Ir（III）发光复合物，包含这些络合物作为标记的缀合物及其应用，例如在基于电化学发光的检测分析物中。
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公开(公告)号：US20210229098A1
公开(公告)日：2021-07-29
申请号：US17229086
申请日：2021-04-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Thorsten Brueckner , Thomas Fischer , Eloisa Lopez-Calle , Sascha Lutz , Josef Roedl , Juergen Spinke , Pamela Espindola , Thomas Manuel Keller , Thomas Dolbinow , Sabrina Adler , Erik Beiersdorf , Domenik Wensorra
Abstract: A medical system for determining an analyte quantity in a blood sample via a cartridge that spins around a rotational axis. The cartridge may include: a separation chamber that separates blood plasma from the sample; a processing chamber containing a reagent with a specific binding partner which binds to the analyte to form an analyte specific binding partner complex; a first valve structure connecting the separation chamber to the processing chamber; a measurement structure to measure the quantity of the analyte, wherein the measurement structure includes a chromatographic membrane with an immobilized binding partner for direct or indirect binding of the analyte or the analyte specific binding partner complex, and an absorbent structure that is nearer to the axis than the membrane; a second valve structure connecting the processing chamber to the measurement structure; and a fluid chamber filled with a washing buffer and fluidically connected to the measurement structure.
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