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1.发明申请公开(公告)号：US20180231544A1
公开(公告)日：2018-08-16
申请号：US15951536
申请日：2018-04-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Eloisa Lopez-Calle , Norbert Oranth , Josef Roedl
IPC: G01N33/543 , G01N33/573 , G01D18/00 , G16H50/30 , G06F19/18 , G01N21/78 , G01N33/52 , G01N21/63 , G01N33/92 , G01N21/27 , G01N21/82 , G01N33/68
CPC classification number: G01N33/54393 , G01D18/00 , G01N21/274 , G01N21/63 , G01N21/78 , G01N21/82 , G01N33/52 , G01N33/54313 , G01N33/54346 , G01N33/573 , G01N33/6827 , G01N33/92 , G01N2021/825 , G06F19/18 , G16H50/30 , Y02A90/26
Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.
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公开(公告)号：US09573131B2
公开(公告)日：2017-02-21
申请号：US14530857
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Peter Koltay , Norbert Oranth , Juergen Spinke , Laurent Tanguy
CPC classification number: B01L3/52 , B01L1/00 , B01L3/523 , B01L5/00 , B01L2200/0684 , B01L2200/141 , B01L2300/048 , B01L2300/0681 , B01L2400/086 , G01N35/1002 , Y10T436/11
Abstract: A cartridge for dispensing a fluid is presented. The cartridge comprises a reservoir chamber for receiving the fluid and for receiving a ventilation gas. The reservoir chamber comprises an inlet for receiving the ventilation gas and an outlet for dispensing the fluid. At least a portion of the reservoir chamber is filled with the ventilation gas when in an operating position. The inlet is located in the portion being filled with the ventilation gas. The fluid comprises a reagent. The cartridge further comprises a baffle for restricting gas diffusion through the inlet. The reservoir chamber receives the ventilation gas via the baffle. The inlet is maintains a constant gas pressure within the portion of the reservoir chamber that is being filled with the ventilation gas.
Abstract translation: 呈现用于分配流体的盒。 墨盒包括用于接收流体并用于接收通气气体的储存室。 储存室包括用于接收通气气体的入口和用于分配流体的出口。 当处于操作位置时，储存室的至少一部分填充有通气气体。 入口位于填充有通气气体的部分中。 流体包含试剂。 墨盒还包括用于限制通过入口的气体扩散的挡板。 储存室通过挡板接收通气气体。 入口在储存室的被填充有通风气体的部分内保持恒定的气体压力。
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公开(公告)号：US20180071740A1
公开(公告)日：2018-03-15
申请号：US15819165
申请日：2017-11-21
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Nadine Losleben , Norbert Oranth
CPC classification number: B01L3/523 , B01F3/12 , B01F15/0462 , B01L3/502 , B01L2200/04 , B01L2200/0647 , B01L2200/16 , B01L2300/0867 , B01L2400/0478 , B01L2400/0622 , B01L2400/0644 , G01N33/5304 , G01N35/1002 , G01N2035/00574
Abstract: A method of dispensing a particle mixture and a reagent fluid cartridge are presented. The cartridge comprises a first reservoir partially filled with reagent fluid, a second reservoir partially filled with particles, a pumping chamber, a first pumping chamber conduit connecting the first reservoir and the pumping chamber, a second pumping chamber conduit connecting the second reservoir and the pumping chamber, an outlet for dispensing reagent fluid and particles from the cartridge, an outlet conduit connecting the outlet to the pumping chamber, and a valve sealing the outlet conduit. The method comprises closing the valve, applying a force to the plunger to transport a first defined volume of reagent fluid and second defined volume of particles into the pumping chamber to form a mixture of reagent fluid and particles, opening the valve, and forcing the mixture from the pumping chamber using the plunger to dispense the mixture from the outlet.
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公开(公告)号：US20170184622A1
公开(公告)日：2017-06-29
申请号：US15455773
申请日：2017-03-10
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Achim Sinz , Christian Riether , Norbert Oranth , Martin Burri
Abstract: A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. The method is adapted to compensate deviations regarding physical properties of the sample container carriers, the transport plane and the electro-magnetic actuators compared to reference components. A laboratory automation system comprising such a laboratory sample distribution system is also presented.
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公开(公告)号：US20160231344A1
公开(公告)日：2016-08-11
申请号：US15132915
申请日：2016-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
CPC classification number: G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
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Patent Agency Ranking
公开(公告)号：US20150140669A1
公开(公告)日：2015-05-21
申请号：US14530862
申请日：2014-11-03
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thursten Brueckner , Timo Klein
CPC classification number: G01N35/1002 , A61M5/14216 , A61M5/16809 , B01L3/0217 , B01L3/0224 , B01L3/502 , B01L2200/025 , B01L2200/0605 , B01L2200/0684 , B01L2200/16 , B01L2300/0627 , B01L2300/0681 , B01L2400/0478 , B01L2400/0644 , B01L2400/065 , G01F11/021 , G01N35/00871 , G01N35/1016 , G01N35/1097 , G01N2035/1025 , Y10T436/119163 , Y10T436/2575
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
Abstract translation: 提出了用于分配流体的盒。 墨盒包括阀。 阀包括用于泵送流体的泵送室。 阀门定位泵送管道。 泵送室导管连接到泵送室。 墨盒还包括用于改变泵送室的容积的柱塞。 墨盒还包括用于将储存器与阀连接的储存器导管。 阀将泵室导管定位成与储存器导管连接。 墨盒还包括用于分配流体的出口导管。 阀进一步旋转泵送室导管以与出口导管连接。
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7.发明申请SENSITIVITY AND THE DYNAMIC RANGE OF PHOTOMETRIC ASSAYS BY GENERATING MULTIPLE CALIBRATION CURVES 审中-公开通过产生多个校准曲线的灵敏度和光学测量的动态范围公开(公告)号：US20150046114A1
公开(公告)日：2015-02-12
申请号：US14524633
申请日：2014-10-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thornsten Brueckner , Eloisa Lopez-Calle , Norbert Oranth , Josef Roedl
IPC: G01N33/92 , G06F19/18 , G01N21/63 , G01N33/573 , G01N33/68
CPC classification number: G01N33/54393 , G01D18/00 , G01N21/274 , G01N21/63 , G01N21/78 , G01N21/82 , G01N33/52 , G01N33/54313 , G01N33/54346 , G01N33/573 , G01N33/6827 , G01N33/92 , G01N2021/825 , G16B20/00 , G16H50/30 , Y02A90/26
Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.
Abstract translation: 用于通过光度测定法确定特定分析物的量的方法，其中样品中的特定分析物与反应混合物中的分析物特异性反应伴侣反应。 产生至少两个校准曲线，针对低浓度的特定分析物优化以第一波长记录的第一校准曲线，从而使检测下限最大化，并且以第二波长记录的第二校准曲线被优化用于高浓度 特异性分析物，从而最大化上限检测限。 优化的较低检测限和优化的上限检测极限导致扩展的动态范围。
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公开(公告)号：US10330693B2
公开(公告)日：2019-06-25
申请号：US15132915
申请日：2016-04-19
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Peter Kupser , Norbert Oranth , Juergen Spinke , Thorsten Brueckner , Timo Klein
Abstract: A cartridge for dispensing fluid is presented. The cartridge comprises a valve. The valve comprises a pumping chamber for pumping the fluid. The valve positions a pumping chamber conduit. The pumping chamber conduit is connected to the pumping chamber. The cartridge further comprises a plunger for changing the volume of the pumping chamber. The cartridge further comprises a reservoir conduit for connecting the reservoir with the valve. The valve positions the pumping chamber conduit to connect with the reservoir conduit. The cartridge further comprises an outlet conduit for dispensing the fluid. The valve further rotates the pumping chamber conduit to connect with the outlet conduit.
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公开(公告)号：US10509049B2
公开(公告)日：2019-12-17
申请号：US15455773
申请日：2017-03-10
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Achim Sinz , Christian Riether , Norbert Oranth , Martin Burri
Abstract: A method of operating a laboratory sample distribution system is presented. The method comprises a number of sample container carriers on a transport plane by a number of electro-magnetic actuators. The method is adapted to compensate deviations regarding physical properties of the sample container carriers, the transport plane and the electro-magnetic actuators compared to reference components. A laboratory automation system comprising such a laboratory sample distribution system is also presented.
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10.发明授权公开(公告)号：US10288609B2
公开(公告)日：2019-05-14
申请号：US15951536
申请日：2018-04-12
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Thorsten Brueckner , Eloisa Lopez-Calle , Norbert Oranth , Josef Roedl
IPC: G01N21/27 , G01N21/63 , G01N33/52 , G06F19/18 , G01N33/543 , G16B20/00 , G01N21/78 , G01N21/82 , G01D18/00 , G01N33/573 , G01N33/68 , G01N33/92 , G16H50/30
Abstract: A method for determining the amount of a specific analyte by photometric assays, wherein the specific analyte in a sample reacts with an analyte specific reaction partner in a reaction mixture. At least two calibration curves are generated, the first calibration curve recorded at a first wavelength is optimized for low concentrations of the specific analyte thereby maximizing the lower detection limit and, the second calibration curve recorded at a second wavelength is optimized for high concentrations of the specific analyte thereby maximizing the upper detection limit. The optimized lower detection limit and the optimized upper detection limit results in an extended dynamic range.
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