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公开(公告)号：US20150147343A1
公开(公告)日：2015-05-28
申请号：US14322096
申请日：2014-07-02
申请人： Roger NITSCH , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
发明人： Roger NITSCH , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K51/1018 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , G01N33/6854 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/52
摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
摘要翻译： 提供了新型特异性结合分子，特别是人抗体以及其识别疾病相关蛋白的新表型的片段，衍生物和变体，其衍生自天然内源性蛋白质，但是在变体形式和/或出口的患者体内普遍存在 的正常生理环境。 此外，描述了包含这样的结合分子的药物组合物，其抗体及其模拟物以及筛选新结合分子的方法，其可以是或可以不是抗体以及治疗神经疾病如阿尔茨海默病的靶标。
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公开(公告)号：US08906367B2
公开(公告)日：2014-12-09
申请号：US12522031
申请日：2008-01-07
申请人： Roger Nitsch , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
发明人： Roger Nitsch , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/77
摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
摘要翻译： 提供了新型特异性结合分子，特别是人抗体以及其识别疾病相关蛋白的新表型的片段，衍生物和变体，其衍生自天然内源性蛋白质，但是在变体形式和/或出口的患者体内普遍存在 的正常生理环境。 此外，描述了包含这样的结合分子的药物组合物，其抗体及其模拟物以及筛选新结合分子的方法，其可以是或可以不是抗体以及治疗神经疾病如阿尔茨海默病的靶标。
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公开(公告)号：US20100202968A1
公开(公告)日：2010-08-12
申请号：US12522031
申请日：2008-01-07
申请人： Roger Nitsch , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
发明人： Roger Nitsch , Christoph Hock , Christoph Esslinger , Marlen Knobloch , Kathrin Tissot , Jan Grimm
IPC分类号： A61K49/00 , G01N33/50 , C07K16/00 , C07H21/00 , C12N15/74 , C12N5/10 , C12P21/02 , A61K31/7088 , A61K35/12 , A61K39/395 , A61K39/00 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/00 , C07K2317/21 , C07K2317/77
摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.
摘要翻译： 提供了新型特异性结合分子，特别是人抗体以及其识别疾病相关蛋白的新表型的片段，衍生物和变体，其衍生自天然内源性蛋白质，但是在变体形式和/或出口的患者体内普遍存在 的正常生理环境。 此外，描述了包含这样的结合分子的药物组合物，其抗体及其模拟物以及筛选新结合分子的方法，其可以是或可以不是抗体以及治疗神经疾病如阿尔茨海默病的靶标。
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公开(公告)号：US20100330075A1
公开(公告)日：2010-12-30
申请号：US12530764
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Alfred Zippelius , Dirk Jaeger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Goebels
发明人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Alfred Zippelius , Dirk Jaeger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Goebels
IPC分类号： A61K39/395 , C12P21/04 , C12N9/96 , C12N5/10 , C12N15/63 , G01N33/53 , C07K14/705 , C07K7/06 , C07K7/08 , C07K5/10 , C07K5/08 , C07K16/30 , C07H21/04 , A61P35/00 , A61P35/02
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.
摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。
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公开(公告)号：US20110123447A1
公开(公告)日：2011-05-26
申请号：US12450101
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Roger Nitsch , Holger Moch , Norbert Goebels , Dirk Jaeger , Alfred Zippelius , Alexander Knuth
发明人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Roger Nitsch , Holger Moch , Norbert Goebels , Dirk Jaeger , Alfred Zippelius , Alexander Knuth
IPC分类号： A61K39/395 , G01N33/53 , C12P21/00 , C07K16/18 , C07K14/47 , C07H21/00 , C12N15/63 , C12N5/10 , C12N9/96 , A61P35/00 , A61K49/00
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel tumor-specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigens and that are obtained from a tumor patient who shows at least partial clinical response or is symptom-free. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of tumors are described.
摘要翻译： 提供了新的肿瘤特异性结合分子，特别是人抗体以及识别肿瘤相关抗原的片段，衍生物和变体，并且其从显示至少部分临床反应或无症状的肿瘤患者获得。 此外，描述了包含这样的结合分子，抗体及其模拟物的药物组合物以及筛选新结合分子的方法，其可以是或可以不是抗体以及肿瘤治疗中的靶标。
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公开(公告)号：US08519106B2
公开(公告)日：2013-08-27
申请号：US12530764
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Künzle , Irene Abela , Alfred Zippelius , Dirk Jäger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Göbels
发明人： Christoph Esslinger , Sandra Künzle , Irene Abela , Alfred Zippelius , Dirk Jäger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Göbels
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.
摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。
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7.发明申请METHOD OF PROVIDING IMMUNOGLOBULIN SECRETING B LYMPHOCYTES AND HUMAN ANTIBODIES 审中-公开提供免疫球蛋白分泌B淋巴细胞和人抗体的方法公开(公告)号：US20110171688A1
公开(公告)日：2011-07-14
申请号：US12991422
申请日：2009-06-16
申请人： Christoph Esslinger
发明人： Christoph Esslinger
CPC分类号： C07K16/1282 , C07K16/00 , C07K2317/10 , C12N2510/04 , C12N2799/027
摘要： Provided is a method for producing a clone of an immortalized human B memory lymphocyte, comprising the step of inducing or enhancing telomerase activity in the B lymphocyte in the presence of a polyclonal B cell activator. The method is particularly useful in a method for producing a clone of an immortalized human B memory lymphocyte capable of producing a human monoclonal antibody with desired antigen specificity.
摘要翻译： 提供一种生产永生化人B记忆淋巴细胞克隆的方法，其包括在多克隆B细胞激活剂存在下在B淋巴细胞中诱导或增强端粒酶活性的步骤。 该方法特别可用于生产能够产生具有所需抗原特异性的人单克隆抗体的永生化人B记忆淋巴细胞克隆的方法。
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8.发明申请公开(公告)号：US20130295091A1
公开(公告)日：2013-11-07
申请号：US13978995
申请日：2012-01-10
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K39/39541 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K2317/565
摘要： The present invention relates to a combination therapy including tumor associated antigen binding antibodies.
摘要翻译： 本发明涉及包括肿瘤相关抗原结合抗体的组合疗法。
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公开(公告)号：US20140186363A1
公开(公告)日：2014-07-03
申请号：US14123584
申请日：2012-05-23
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to MAGEA3 binding antibodies.
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公开(公告)号：US20140093514A1
公开(公告)日：2014-04-03
申请号：US14123593
申请日：2012-05-23
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to MAGEA3 binding antibodies.
摘要翻译： 本发明涉及MAGEA3结合抗体。
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