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公开(公告)号：US20200300750A1
公开(公告)日：2020-09-24
申请号：US16088321
申请日：2017-03-23
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra-erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20210041422A1
公开(公告)日：2021-02-11
申请号：US17082615
申请日：2020-10-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N15/06 , G01N33/569
Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.
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公开(公告)号：US20190302099A1
公开(公告)日：2019-10-03
申请号：US16098893
申请日：2017-05-11
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel POLLAK , Sarah LEVY SCHREIER , Yochay Shlomo ESHEL , Amir ZAIT , Sharon PECKER
Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20250076176A1
公开(公告)日：2025-03-06
申请号：US18952650
申请日：2024-11-19
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described including acquiring first and second images of a blood sample at respective times and determining whether, between acquisitions of the first and second images, there was motion of an entity, by comparing the first and second images to one another. At least partially in response thereto, the entity is identified, and an output is generated on the output device, at least partially in response to identification of the entity. Other applications are also described.
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公开(公告)号：US20220390372A1
公开(公告)日：2022-12-08
申请号：US17770339
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20220381672A1
公开(公告)日：2022-12-01
申请号：US17770365
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.
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公开(公告)号：US20210072526A1
公开(公告)日：2021-03-11
申请号：US17083659
申请日：2020-10-29
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Noam YORAV-RAPHAEL , Joseph Joel POLLAK , Sarah LEVY SCHREIER , Yochay Shlomo ESHEL
Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.
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公开(公告)号：US20190145963A1
公开(公告)日：2019-05-16
申请号：US16099270
申请日：2017-05-11
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N33/569 , G01N15/06
Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.
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