公开(公告)号：US20250108367A1

公开(公告)日：2025-04-03

申请号：US18832199

申请日：2023-01-25

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Sharon PECKER ,  Noam MORALI ,  Aviram STEINBOK ,  Yochay Shlomo ESHEL ,  Trevor RUGGIERO ,  Kristofer KURTIN ,  Joseph Joel POLLAK ,  Daniel LEVNER ,  Julie RICHARDSON

IPC: B01L3/00

Abstract: Apparatus and methods are described for analyzing a bodily sample. A sample carrier (22), which houses the bodily sample, includes at least one fluidic channel (120), at least one analysis chamber (68), and a receptacle (92) that houses a diluent. A pump system (150) pumps the diluent from the receptacle (92) into the fluidic channel (120) in a first fluid flow direction, and subsequently, pumps the diluent and the bodily sample in a second fluid flow direction, which is a reverse of the first fluid flow direction, to thereby mix the diluent and the bodily sample within the receptacle (92). Other applications are also described.

公开(公告)号：US20250076287A1

公开(公告)日：2025-03-06

申请号：US18951911

申请日：2024-11-19

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Amir ZAIT ,  Arnon HOURI YAFIN ,  Dan GLuck ,  Sharon PECKER ,  Yochay Shlomo ESHEL ,  Sarah LEVYS CHREIER ,  Joseph Joel POLLAK

IPC: G01N33/50 ,  G01N15/01 ,  G01N15/06 ,  G01N33/49 ,  G01N33/569 ,  G01N33/72

Abstract: Apparatus and methods are described including measuring a measurand within a first portion of a bodily sample, measuring relative amounts of first and second components within a second portion of the bodily sample that is diluted relative to the first portion of the bodily sample, and determining a parameter of the bodily sample based upon the measurand within the first portion of the bodily sample and the relative amounts of first and second components within the second portion of the bodily sample. Other applications are also described.

公开(公告)号：US20210041422A1

公开(公告)日：2021-02-11

申请号：US17082615

申请日：2020-10-28

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Amir ZAIT ,  Arnon HOURI YAFIN ,  Dan GLUCK ,  Sharon PECKER ,  Yochay Shlomo ESHEL ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK

IPC: G01N33/50 ,  G01N33/49 ,  G01N15/06 ,  G01N33/569

Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.

公开(公告)号：US20190302099A1

公开(公告)日：2019-10-03

申请号：US16098893

申请日：2017-05-11

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Joseph Joel POLLAK ,  Sarah LEVY SCHREIER ,  Yochay Shlomo ESHEL ,  Amir ZAIT ,  Sharon PECKER

IPC: G01N33/50 ,  G01N21/59 ,  G01N21/64 ,  G01N21/31

Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.

公开(公告)号：US20230011382A1

公开(公告)日：2023-01-12

申请号：US17783831

申请日：2020-12-10

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Dan GLUCK ,  Amir ZAIT ,  Arnon HOURI YAFIN ,  Yonatan HALPERIN ,  Yochay Shlomo ESHEL ,  Sarah LEVY ,  Joseph Joel POLLAK ,  Sharon PECKER ,  Peretz YAFIN ,  Dana BENBASSAT ,  David BRAILOVSKY ,  Uriyah PUMERANTZ

IPC: G02B21/00 ,  G06T7/00

Abstract: Apparatus and methods are described use with a bodily sample that contains cells. A microscope (24) is focused, such that a focal plane of the microscope (24) at least approximately coincides with a level at which at least some cells belonging to the sample are at least partially disposed. At least one on-focus microscopic image of the sample, while the focal plane of the microscope (24) approximately coincides with the level. The microscope (24) is focused such that the focal plane of the microscope is offset with respect to the level, at least one off-focus microscopic image of the sample is acquired, while the focal plane of the microscope (24) is offset with respect to the level. A property of at least a portion of the sample is determined, at least partially based upon the on-focus and off-focus images. Other applications are also described.

公开(公告)号：US20220390372A1

公开(公告)日：2022-12-08

申请号：US17770339

申请日：2020-10-22

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Sharon PECKER ,  Yochay Shlomo ESHEL ,  Amir ZAIT ,  Dan GLUCK ,  Noam YORAV-RAPHAEL ,  Arnon HOURI YAFIN ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK ,  Daniel LEVNER ,  Yonatan HALPERIN ,  Natalie LEZMY ,  Itamar WEISS

IPC: G01N21/64 ,  G06T7/00

Abstract: Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.

公开(公告)号：US20220381672A1

公开(公告)日：2022-12-01

申请号：US17770365

申请日：2020-10-22

Applicant: S.D. SIGHT DIAGNOSTICS LTD.

Inventor： Sharon PECKER ,  Yochay Shlomo ESHEL ,  Amir ZAIT ,  Dan GLUCK ,  Noam YORAV-RAPHAEL ,  Arnon HOURI YAFIN ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK ,  Daniel LEVNER ,  Yonatan HALPERIN ,  Natalie LEZMY ,  Itamar WEISS

IPC: G01N15/14 ,  G01N33/49 ,  G06V20/69

Abstract: Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.

公开(公告)号：US20220299436A1

公开(公告)日：2022-09-22

申请号：US17836561

申请日：2022-06-09

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Amitai FRANKLIN ,  Trevor RUGGIERO ,  Sarah LEVY ,  Joseph Joel POLLAK ,  Aidan John CARROLL ,  Sharon PECKER ,  Yochay Shlomo ESHEL

IPC: G01N21/3577 ,  G02B21/36 ,  G02B21/02 ,  G01N21/31

Abstract: Apparatus and methods are described for use with a microscopy unit that comprises an objective lens and a microscope camera. A cantilever includes an objective lens housing. A motor moves the cantilever along a direction of the optical axis of the objective lens. The cantilever is configured, during the movement of the cantilever, to support the objective lens within the objective lens housing such that an optical axis of the objective lens is aligned with the camera, without the objective lens being directly connected to the camera. Other applications are also described.

公开(公告)号：US20190145963A1

公开(公告)日：2019-05-16

申请号：US16099270

申请日：2017-05-11

Applicant: S.D. Sight Diagnostics Ltd.

Inventor： Amir ZAIT ,  Arnon HOURI YAFIN ,  Dan GLUCK ,  Sharon PECKER ,  Yochay Shlomo ESHEL ,  Sarah LEVY SCHREIER ,  Joseph Joel POLLAK

IPC: G01N33/50 ,  G01N33/49 ,  G01N33/569 ,  G01N15/06

Abstract: Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.