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    Method for the synthesis of quaternary ammonium salts
    1.
    发明授权
    Method for the synthesis of quaternary ammonium salts 失效
    季铵盐的合成方法

    公开(公告)号：US5349067A

    公开(公告)日：1994-09-20

    申请号：US45540

    申请日：1993-04-09

    申请人： Shinji Nakano ,  Takao Morimoto ,  Takeshi Endo

    发明人： Shinji Nakano ,  Takao Morimoto ,  Takeshi Endo

    IPC分类号： C07D213/79 ,  C07C209/60 ,  C07C211/64 ,  C07D213/20 ,  C07D213/84 ,  C07D211/10 ,  C07D211/18 ,  C07D211/26

    CPC分类号： C07D213/20 ,  C07D213/84

    摘要： Provided is a convenient method for the synthesis of quaternary ammonium sulfonate compounds which are useful as curing catalysts for one-part thermosetting resin compositions which maintain storage stability at room temperature. The compounds are synthesized by subjecting in one step a benzyl alcohol optionally having on the benzene ring and/or the .alpha.-position one or more substituent groups to reaction with a corresponding tertiary amine and an organic sulfonic acid chloride.

    摘要翻译： 提供了合成季铵磺酸盐化合物的方便方法，其可用作在室温下保持储存稳定性的一部分热固性树脂组合物的固化催化剂。 所述化合物通过一步法将在苯环上和/或α位上的一个或多个取代基任选地含有苄醇与相应的叔胺和有机磺酰氯反应来合成。

    Method for the synthesis of quaternary ammonium salts
    2.
    发明授权
    Method for the synthesis of quaternary ammonium salts 失效
    季铵盐的合成方法

    公开(公告)号：US5399695A

    公开(公告)日：1995-03-21

    申请号：US45531

    申请日：1993-04-09

    申请人： Shinji Nakano ,  Takao Morimoto ,  Takeshi Endo

    发明人： Shinji Nakano ,  Takao Morimoto ,  Takeshi Endo

    IPC分类号： C07C209/60 ,  C07C211/64 ,  C07C217/58 ,  C07D213/20 ,  C07C211/27 ,  C07F9/92

    CPC分类号： C07D213/20 ,  C07C209/60 ,  C07C211/64 ,  C07C217/58

    摘要： Provided is a convenient method for synthesizing quaternary ammonium salts which are useful as curing catalysts for one-part thermosetting resin compositions which maintain storage stability at room temperature. The ammonium salts are synthesized by direct reaction of a benzyl alcohol or a benzyl alkyl ether optionally having on the benzene ring and/or at .alpha.-position one or more substituent groups inert to the intended reaction, with a corresponding strong-acid salt of a tertiary amine.

    摘要翻译： 提供合成季铵盐的方便方法，其可用作在室温下保持储存稳定性的一部分热固性树脂组合物的固化催化剂。 铵盐通过苯甲醇或任选在苯环上和/或α位上一个或多个对预期反应呈惰性的取代基的苯甲醇或苄基烷基醚与相应的强酸盐 叔胺。

    Process for Preparing Episulfide Compounds
    8.
    发明申请
    Process for Preparing Episulfide Compounds 有权
    制备二硫化锡化合物的方法

    公开(公告)号：US20140107350A1

    公开(公告)日：2014-04-17

    申请号：US14112795

    申请日：2012-04-20

    申请人： Akitake Nakamura ,  Takeshi Endo

    发明人： Akitake Nakamura ,  Takeshi Endo

    IPC分类号： C07D331/02

    CPC分类号： C07D331/02

    摘要： Provided is a method for producing an episulfide compound, the method including a step of thiating epoxy groups of (B) an epoxy compound by a reaction with (C) a thiating agent in the presence of (A) a polyhydric hydroxyl compound having two or more hydroxyl groups.

    摘要翻译： 提供了一种环硫化合物的制备方法，该方法包括在（A）具有两个或多个羟基化合物的多羟基化合物的存在下，通过与（C）硫化剂的反应，将（B）环氧化合物的环氧基 更多的羟基。

    Quinazoline derivatives having tyrosine kinase inhibitory activity
    9.
    发明授权
    Quinazoline derivatives having tyrosine kinase inhibitory activity 有权
    具有酪氨酸激酶抑制活性的喹唑啉衍生物

    公开(公告)号：US08349857B2

    公开(公告)日：2013-01-08

    申请号：US13359326

    申请日：2012-01-26

    申请人： Masaharu Kume ,  Kenji Matsuo ,  Naoki Omori ,  Masami Takayama ,  Aiko Omori ,  Takeshi Endo

    发明人： Masaharu Kume ,  Kenji Matsuo ,  Naoki Omori ,  Masami Takayama ,  Aiko Omori ,  Takeshi Endo

    IPC分类号： A01N43/54 ,  A61K31/517 ,  C07D239/72

    CPC分类号： C07D239/94 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12

    摘要： A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided.A compound represented by the general formula (I): wherein RX is a group represented by the formula: wherein R1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R10)—, etc.; R10 is a hydrogen atom, alkyl, etc.; R2 is a hydrogen atom, optionally substituted alkyl, etc.; R18 is a hydrogen atom, optionally substituted alkyl, etc.; R19 is optionally substituted alkyl, etc.; W1 is an optionally substituted non-aromatic nitrogen-containing group; R17 is a hydrogen atom, optionally substituted alkyl, etc.; R3 and R4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R12)—, etc.; R12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.

    摘要翻译： 提供抑制EGF受体酪氨酸激酶和HER2酪氨酸激酶两者的化合物。 由通式（I）表示的化合物：其中RX是由下式表示的基团：其中R1是氢原子，任选取代的烷基等; Z是-O - ， - N（R 10） - 等; R10是氢原子，烷基等; R2是氢原子，任选取代的烷基等; R18是氢原子，任意取代的烷基等; R19是任选取代的烷基等; W1是任选取代的非芳族含氮基团; R 17是氢原子，任选取代的烷基等; R3和R4独立地是氢原子，任选取代的烷基等; X是-O-，-S-或-N（R 12） - 等; R12是氢原子，烷基等; 和A是任选具有取代基的苯基等，其药学上可接受的盐或其溶剂合物。

    FILTERING ACOUSTIC WAVEFORMS IN DOWNHOLE ENVIRONMENTS
    10.
    发明申请
    FILTERING ACOUSTIC WAVEFORMS IN DOWNHOLE ENVIRONMENTS 有权
    在井下环境中滤波声波

    公开(公告)号：US20120147702A1

    公开(公告)日：2012-06-14

    申请号：US13310780

    申请日：2011-12-04

    申请人： Henri-Pierre Valero ,  Shinichi Sunaga ,  Takeshi Endo

    发明人： Henri-Pierre Valero ,  Shinichi Sunaga ,  Takeshi Endo

    IPC分类号： G01V1/40

    CPC分类号： G01V1/48 ,  G01V1/44 ,  G01V2210/23

    摘要： Methods and apparatus to filter acoustic waveforms in downhole environments are described. An example method involves receiving acoustic waveform data representing acoustic signals traversing at least a portion of a borehole adjacent a subterranean formation and performing a direct transform operation on the acoustic waveform data to generate wavelet map data. The wavelet map data comprises a time-frequency representation of the acoustic waveform data. The example method also involves identifying a waveform of interest via the wavelet map data, extracting data associated with the waveform of interest from the wavelet map data, generating filtered wavelet map data based on the extracted data, and performing an inverse transform operation on the filtered wavelet map data to generate filtered acoustic waveform data

    摘要翻译： 描述了在井下环境中滤波声波的方法和装置。 示例性方法包括接收表示穿过邻近地层的钻孔的至少一部分的声信号的声波形数据，并且对声波形数据执行直接变换操作以产生小波图数据。 小波图数据包括声波形数据的时间 - 频率表示。 该示例方法还涉及通过小波变换图数据识别感兴趣的波形，从小波变换数据中提取与感兴趣波形相关联的数据，基于所提取的数据产生滤波后的小波变换数据，并对经滤波的 小波图数据生成滤波后的声波形数据