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公开(公告)号：US09266831B2
公开(公告)日：2016-02-23
申请号：US14303238
申请日：2014-06-12
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tomomi Ikemoto , Toshiaki Nagata , Naohiro Fukuda
IPC: C07D207/34 , C07D207/337 , C07D207/333 , C07D207/36 , C07D401/12 , C07C225/14 , C07D207/30 , C07D207/48
CPC classification number: C07D207/337 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
Abstract translation: 本发明提供了可用作药物的磺酰基吡咯化合物的制备方法，用于该方法的中间体的制备方法和新的中间体。 本发明涉及一种制备磺酰基吡咯化合物（Ⅷ）的方法，其包括还原化合物（III）并水解还原产物得到化合物（Ⅳ），使化合物（Ⅳ）进行磺酰化反应得到化合物（Ⅵ）， 并使化合物（VI）进行胺化反应。
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公开(公告)号：US10730904B2
公开(公告)日：2020-08-04
申请号：US16240677
申请日：2019-01-04
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Mitsuru Nonogawa , Toshiaki Nagata , Hideki Saito , Tsuneo Yasuma
IPC: C07H19/207 , C07H19/06 , C07H19/16 , C07H19/067 , C07H19/073 , C07H21/04 , C07H21/00 , C07H1/00 , C07H19/167
Abstract: In this method, an oligonucleotide represented by formula (II) [wherein Y1, Q, Base, r and r′ are each as defined in claim 1] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.
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公开(公告)号：US20190127324A1
公开(公告)日：2019-05-02
申请号：US16200178
申请日：2018-11-26
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
IPC: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/48 , C07D401/12 , C07D207/30 , C07D207/36
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：US10214555B2
公开(公告)日：2019-02-26
申请号：US14442601
申请日：2013-11-13
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Mitsuru Nonogawa , Toshiaki Nagata , Hideki Saito , Tsuneo Yasuma
IPC: C07H1/00 , C07H21/00 , C07H21/04 , C07H19/06 , C07H19/16 , C07H19/067 , C07H19/073 , C07H19/167 , C07H19/207
Abstract: In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in Claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method cars dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.
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公开(公告)号：US11498898B2
公开(公告)日：2022-11-15
申请号：US17021701
申请日：2020-09-15
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Takeshi Yamasaki
IPC: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/36 , C07D401/12 , C07D207/30 , C07D207/48
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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Patent Agency Ranking
公开(公告)号：US20210070705A1
公开(公告)日：2021-03-11
申请号：US17021701
申请日：2020-09-15
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tomomi Ikemoto , Misayo Sera , Naohiro Fukuda , Hideya Mizufune , Toshiaki Nagata , Takeshi Yamasaki
IPC: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/36 , C07D401/12 , C07D207/30 , C07D207/48
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：US10173977B2
公开(公告)日：2019-01-08
申请号：US14994360
申请日：2016-01-13
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
IPC: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/36 , C07D401/12 , C07D207/30 , C07D207/48
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：US10336864B2
公开(公告)日：2019-07-02
申请号：US15727760
申请日：2017-10-09
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Mitsuhisa Yamano , Toshiaki Nagata , Hideki Saitoh
Abstract: The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.
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公开(公告)号：US20230088365A1
公开(公告)日：2023-03-23
申请号：US17961978
申请日：2022-10-07
Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Inventor： Tomomi Ikemoto , Misayo Sera , Naohiro Fukuda , Hideya Mizufune , Toshiaki Nagata , Takeshi Yamasaki
IPC: C07D207/337 , C07D207/333 , C07D207/34 , C07D207/36 , C07D401/12 , C07D207/30 , C07D207/48
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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公开(公告)号：US20180009746A1
公开(公告)日：2018-01-11
申请号：US14994360
申请日：2016-01-13
Applicant: Takeda Pharmaceutical Company Limited
Inventor： Tomomi Ikemoto , Hideya Mizufune , Toshiaki Nagata , Misayo Sera , Naohiro Fukuda , Takeshi Yamasaki
IPC: C07D207/337 , C07D207/48 , C07D207/34 , C07C225/14 , C07D207/333 , C07D207/30 , C07D401/12 , C07D207/36
CPC classification number: C07D207/337 , C07D207/30 , C07D207/333 , C07D207/34 , C07D207/36 , C07D207/48 , C07D401/12
Abstract: The present invention provides a production method of a sulfonylpyrrole compound useful as a pharmaceutical product, a production method of an intermediate used for the method, and a novel intermediate. The present invention relates to a method of producing sulfonylpyrrole compound (VIII), which includes reducing compound (III) and hydrolyzing the reduced product to give compound (IV), subjecting compound (IV) to a sulfonylation reaction to give compound (VI), and subjecting compound (VI) to an amination reaction.
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