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    EVALUATION DEVICE, LEARNING DEVICE, PREDICTION DEVICE, EVALUATION METHOD, PROGRAM, AND COMPUTER-READABLE STORAGE MEDIUM
    2.
    发明申请
    EVALUATION DEVICE, LEARNING DEVICE, PREDICTION DEVICE, EVALUATION METHOD, PROGRAM, AND COMPUTER-READABLE STORAGE MEDIUM 有权

    公开(公告)号：US20230121965A1

    公开(公告)日：2023-04-20

    申请号：US18069509

    申请日：2022-12-21

    Applicant: TOPPAN INC. ,  Japanese Foundation For Cancer Research

    Inventor： Shiro KITANO ,  Eiji SHINOZAKI

    IPC: G06N3/09

    Abstract: An evaluation device for evaluating an anticancer effect includes a learning information acquisition unit that acquires learning data that includes state information which indicates at least a cancer state in an unspecified subject and training data that is information about an effect of an anticancer agent obtained by administering the anticancer agent to cells collected from the subject, a learning unit that generates a prediction model by causing a learning model to perform supervised learning for a corresponding relationship between the learning data and the training data, and a prediction unit that makes related predictions to therapy using the anticancer agent with the prediction model. The learning information acquisition unit acquires the information about the anticancer effect obtained by administering the anticancer agent to a three-dimensional cell structure including cancer cells collected from the unspecified subject and cells constituting a stroma as the training data.

    PRODUCTION METHOD OF FRAGMENTED EXTRACELLULAR MATRIX COMPONENT
    4.
    发明公开
    PRODUCTION METHOD OF FRAGMENTED EXTRACELLULAR MATRIX COMPONENT 审中-公开

    公开(公告)号：US20240301347A1

    公开(公告)日：2024-09-12

    申请号：US18578247

    申请日：2022-06-29

    Applicant: TOPPAN INC. ,  OSAKA UNIVERSITY

    Inventor： Asuka YAMADA ,  Shiro KITANO ,  Michiya MATSUSAKI

    IPC: C12N5/00

    CPC classification number: C12N5/0068 ,  C12N2533/54 ,  C12N2533/90 ,  C12N2537/00

    Abstract: One aspect of the present invention relates to a production method of a fragmented extracellular matrix component, the method including: a step of neutralizing a solution in which an extracellular matrix component is dissolved; a step of obtaining a mass containing the extracellular matrix component by removing the solvent through freeze-drying treatment after the neutralization step; a step of obtaining a liquid containing the fragmented extracellular matrix component by dispersing the mass in a solution containing a polar organic solvent and fragmenting the extracellular matrix component in the solution; and a step of removing a liquid component from the liquid containing the fragmented extracellular matrix component.

    METHODS OF PRODUCING THREE-DIMENSIONAL CELLULAR TISSUES, AND THREE-DIMENSIONAL CELLULAR TISSUES
    9.
    发明公开
    METHODS OF PRODUCING THREE-DIMENSIONAL CELLULAR TISSUES, AND THREE-DIMENSIONAL CELLULAR TISSUES 审中-公开

    公开(公告)号：US20240174982A1

    公开(公告)日：2024-05-30

    申请号：US18437415

    申请日：2024-02-09

    Applicant: TOPPAN Inc.

    Inventor： Shiro KITANO ,  Kei TSUKAMOTO ,  Yuma YOKOKAWA

    IPC: C12N5/077 ,  C12N5/09

    CPC classification number: C12N5/0669 ,  C12N5/0693 ,  C12N2501/90 ,  C12N2501/998 ,  C12N2513/00 ,  C12N2533/56 ,  C12N2533/76

    Abstract: A method of producing three-dimensional cellular tissues includes: obtaining a stromal cell-containing mixture containing stromal cells, a cationic substance, an extracellular matrix component and a polyelectrolyte, or a stromal cell-containing mixture containing stromal cells, a cationic substance and a fragmented extracellular matrix component; gelling the stromal cell-containing mixture to obtain a first gel composition containing stromal cells; obtaining a target cell-containing mixture containing target cells, a cationic substance, an extracellular matrix component and a polyelectrolyte, or a target cell-containing mixture containing target cells, a cationic substance and a fragmented extracellular matrix component; placing the target cell-containing mixture in contact with the first gel composition; gelling the target cell-containing mixture to obtain a second gel composition containing target cells; and incubating the first gel composition and the second gel composition to obtain three-dimensional cellular tissues.

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