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公开(公告)号：US20230192685A1
公开(公告)日：2023-06-22
申请号：US17927584
申请日：2021-05-26
发明人： Hitoaki NISHIKAWA , Naohiro TAYA , Hiroshi BANNO , Masatoshi YAMADA , Kazuki AZUMA , Ayaka SUZUKI
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A method for producing a compound represented by the formula (X):
or a salt thereof and has a MALT1 inhibitory action, the said method containing a step for producing a compound a compound represented by the formula (B-2):
or a salt thereof and being characterized by comprising crystallizing a salt of a compound represented by the formula (B-1)
and an optically active organic acid.
(In the formulae, each symbol is as defined in the specification.)-
公开(公告)号：US20230117295A1
公开(公告)日：2023-04-20
申请号：US18075853
申请日：2022-12-06
发明人： Koji ONO , Masahiro ITO , Toshio TANAKA , Moriteru ASANO , Takaharu HIRAYAMA , Jun FUJIMOTO , Nobuki SAKAUCHI , Yasuhiro HIRATA , Akinori TOITA , Nao MORISHITA , Hironori KOKUBO , Yasuhiro IMAEDA , Hironobu MAEZAKI , Douglas Robert CARY , Ryo MIZOJIRI , Nobuo CHO , Hiroshi BANNO , Hidekazu TOKUHARA , Yasuyoshi ARIKAWA
IPC分类号： C07D401/14 , C07D403/14 , C07D401/12 , C07D471/10 , C07D495/10 , C07D405/12 , C07D403/12 , C07D213/84 , C07D487/10 , C07D405/14 , A61P35/00
摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20220340527A1
公开(公告)日：2022-10-27
申请号：US17754118
申请日：2020-09-25
发明人： Yuya OGURO , Makoto KAMATA , Shuhei IKEDA , Takeshi WAKABAYASHI , Norihito TOKUNAGA , Taku KAMEI , Mitsuhiro ITO , Shigemitsu MATSUMOTO , Hirotaka KAMITANI , Takaharu HIRAYAMA , Toshio TANAKA , Hiroshi BANNO , Nobuyuki TAKAKURA , Jinichi YONEMORI , Takuya FUJIMOTO
IPC分类号： C07D211/04 , C07D237/08 , C07D239/26 , C07D405/02
摘要： Provided is a heterocyclic compound that can have an antagonistic action on an NMD A receptor containing the NR2B subunit and that is expected to be useful as a prophylactic or therapeutic agent for depression, bipolar disorder, migraine, pain, peripheral symptoms of dementia and the like. A compound represented by the formula (I), wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20190106437A1
公开(公告)日：2019-04-11
申请号：US16094030
申请日：2017-04-27
发明人： Youichi KAWAKITA , Takuto KOJIMA , Noriyuki NII , Yoshiteru ITO , Nobuki SAKAUCHI , Hiroshi BANNO , Xin LIU , Koji ONO , Keisuke IMAMURA , Shinichi IMAMURA
IPC分类号： C07D519/00 , A61P35/00
摘要： Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].
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公开(公告)号：US20180079723A1
公开(公告)日：2018-03-22
申请号：US15563128
申请日：2016-03-30
发明人： Ryo Mizojiri , Moriteru ASANO , Daisuke TOMITA , Hiroshi BANNO , Michiko TAWADA , Noriyuki NII , Krista E. GIPSON , Hironobu MAEZAKI , Shuntaro TSUCHIYA , Mayumi IMAI , Yuichiro AMANO
IPC分类号： C07D213/65 , C07C233/25 , C07D401/12 , C07C255/54 , C07D213/69 , C07C233/18 , C07D263/42 , C07D263/32 , C07D413/04 , C07D239/34 , C07D241/18 , C07D277/34 , C07D231/12 , C07D207/12 , C07D261/08 , C07D417/04 , C07D237/14 , C07D211/46 , C07D213/74 , C07D213/81
CPC分类号： C07D213/65 , A61K31/165 , A61K31/167 , A61K31/277 , A61K31/381 , A61K31/402 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/44 , A61K31/4412 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/451 , A61K31/454 , A61K31/4965 , A61K31/50 , A61K31/501 , A61K31/505 , A61K31/506 , C07C233/18 , C07C233/25 , C07C233/47 , C07C255/54 , C07C2601/02 , C07C2601/14 , C07D207/08 , C07D207/12 , C07D211/44 , C07D211/46 , C07D213/643 , C07D213/69 , C07D213/74 , C07D213/75 , C07D213/81 , C07D231/12 , C07D237/14 , C07D239/34 , C07D241/18 , C07D261/08 , C07D263/32 , C07D263/42 , C07D277/34 , C07D333/20 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D417/04 , C12N9/99 , C12N15/09
摘要： The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.
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公开(公告)号：US20170037057A1
公开(公告)日：2017-02-09
申请号：US15304727
申请日：2015-04-16
发明人： Masanori Okaniwa , Hiroshi BANNO , Takaharu HIRAYAMA , Douglas Robert CARY , Koji ONO , Naoki IWAMURA
IPC分类号： C07D513/04
CPC分类号： C07D513/04 , A61K31/429 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/455 , A61K31/5377
摘要： The present invention provides a fused heterocyclic compound that has CDK 8 and/or CDK 19 inhibitory activity. The present invention provides a compound represented by formula (I) (wherein the symbols are as defined in the description) or a salt thereof.
摘要翻译： （其中符号如说明书中所定义）或其盐。
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公开(公告)号：US20210115067A1
公开(公告)日：2021-04-22
申请号：US17130297
申请日：2020-12-22
发明人： Youichi KAWAKITA , Takuto KOJIMA , Noriyuki NII , Yoshiteru ITO , Nobuki SAKAUCHI , Hiroshi BANNO , Xin LIU , Koji ONO , Keisuke IMAMURA , Shinichi IMAMURA
IPC分类号： C07D519/00 , A61K31/444 , A61K31/53 , A61K31/5025 , A61K31/519 , A61K31/4985 , A61P35/00
摘要： Provided is a compound represented by the following formula, or a salt thereof: [wherein each symbol is as defined herein.].
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公开(公告)号：US20190169166A1
公开(公告)日：2019-06-06
申请号：US16323863
申请日：2017-08-09
发明人： Jun FUJIMOTO , Xin LIU , Osamu KURASAWA , Terufumi TAKAGI , Douglas Robert CARY , Hiroshi BANNO , Yasutomi ASANO , Takuto KOJIMA
IPC分类号： C07D401/12 , C07D239/42 , A61P35/00
摘要： Provided is a heterocyclic compound that may have a GCN2 inhibitory action, and is expected to be useful for the prophylaxis or treatment of GCN2 associated diseases including cancer and the like. A compound represented by the formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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公开(公告)号：US20180002322A1
公开(公告)日：2018-01-04
申请号：US15529816
申请日：2015-11-25
发明人： Ryo Mizojiri , Hiroshi BANNO , Moriteru ASANO , Daisuke TOMITA , Noriyuki Nii , Hironobu MAEZAKI , Michiko TAWADA
IPC分类号： C07D413/04 , C07D471/04 , C07D417/04 , C07D413/14 , C07D405/04 , C07D231/56 , C07D401/04 , C07D333/56 , C07D307/81 , C07D263/57 , C07D498/04 , C07D413/12
CPC分类号： C07D413/04 , A61K31/343 , A61K31/381 , A61K31/416 , A61K31/423 , A61K31/428 , A61K31/437 , A61K31/443 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/517 , A61K31/5377 , C07D231/56 , C07D263/54 , C07D263/57 , C07D307/81 , C07D333/56 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D471/04 , C07D498/04 , C12N15/09
摘要： Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.
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公开(公告)号：US20210363130A1
公开(公告)日：2021-11-25
申请号：US17042394
申请日：2019-03-28
发明人： Koji ONO , Masahiro ITO , Toshio TANAKA , Moriteru ASANO , Takaharu HIRAYAMA , Jun FUJIMOTO , Nobuki SAKAUCHI , Yasuhiro HIRATA , Akinori TOITA , Nao MORISHITA , Hironori KOKUBO , Yasuhiro IMAEDA , Hironobu MAEZAKI , Douglas Robert CARY , Ryo MIZOJIRI , Nobuo CHO , Hiroshi BANNO , Hidekazu TOKUHARA , Yasuyoshi ARIKAWA
IPC分类号： C07D401/14 , A61P35/00 , C07D401/12 , C07D405/14 , C07D405/12 , C07D213/84 , C07D403/14 , C07D403/12 , C07D471/10 , C07D487/10 , C07D495/10
摘要： Provided is a compound that may have a superior CDK12 inhibitory action and is expected to be useful as a prophylactic or therapeutic drug for cancer and the like. A compound represented by the following formula (I): wherein each symbol is as described in the DESCRIPTION, or a salt thereof.
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