公开(公告)号：US06517082B2

公开(公告)日：2003-02-11

申请号：US09845832

申请日：2001-05-01

申请人： Takeshi Yamada ,  Takayuki Imai ,  Yasuhiro Ikeda

发明人： Takeshi Yamada ,  Takayuki Imai ,  Yasuhiro Ikeda

IPC分类号： F16J1532

CPC分类号： F16J15/3232 ,  F16J15/322 ,  F16J15/3244

摘要： An elastomer lip member with its rear supported by a pressure resisting back-up ring, and a synthetic resin lip member arranged on a rear side of the elastomer lip are comprised, and on the inner circumferential surface of the seal lip portion of the elastomer lip member, helical grooves generating a pumping action of a fluid introducing direction from an inner space of machine side when a shaft rotates are formed. When a pressure in the inner space of machine is MPa (gage), by making a contact width between the seal lip portion of the elastomer lip member and a shaft at least 0.6 mm, so that a surface pressure maximum portion of the seal lip portion of the elastomer lip member to the shaft is biased or maldistributed toward its rear side whereby a fluid introduction by said helical grooves is performed satisfactorily.

摘要翻译： 弹性体唇缘构件，其背面由耐压支撑环支撑，并且配置在弹性体唇缘的后侧的合成树脂唇缘构件，并且在弹性体唇缘的密封唇部的内周面上 形成了当轴旋转时从机器侧的内部空间产生流体引入方向的泵送作用的螺旋槽。 当机器内部空间的压力为MPa（量具）时，通过使弹性体唇形构件的密封唇部与轴之间的接触宽度至少为0.6mm，使得密封唇部的表面压力最大部分 弹性体唇缘构件向轴的偏压或向其后侧分布不均，由此令人满意地执行所述螺旋槽的流体引入。

公开(公告)号：US06422570B1

公开(公告)日：2002-07-23

申请号：US09809353

申请日：2001-03-16

申请人： Yasuhiro Ikeda ,  Takeshi Yamada ,  Takayuki Imai

发明人： Yasuhiro Ikeda ,  Takeshi Yamada ,  Takayuki Imai

IPC分类号： F16J1532

摘要： A lip type seal is provided with an outer ring part (31) which is tightly fitted to a seal installation part (12) of a housing (1); a seal main body (32) which is fixed to the outer ring part (31) and whose inner circumferential part extending in a bent state to the side of a sealed space (A) is sealably brought into slidable contact with an outer circumferential surface of a rotary shaft (2) inserted in the housing (1); a rear surface support plate (33) which is arranged on the rear side of the seal main body and whose outer circumferential part together with the seal main body (32) is fixed to the outer ring part (31); and a movable support plate (34) which is engaged movably in a radial direction between the seal main body (32) and the rear surface support plate (33) and whose inner diameter is clearance fitted to the outer circumferential surface of the rotary shaft (2). Therefore, such a gap in which the seal main body (32) enters is not formed between the inner circumferential surface of the movable support plate (34) and the outer circumferential surface of the rotary shaft (2).

公开(公告)号：US06565096B2

公开(公告)日：2003-05-20

申请号：US09810330

申请日：2001-03-19

申请人： Yasuhiro Ikeda ,  Takeshi Yamada ,  Takayuki Imai

发明人： Yasuhiro Ikeda ,  Takeshi Yamada ,  Takayuki Imai

IPC分类号： F16J1532

CPC分类号： F16J15/3228 ,  F16J15/3216

摘要： In a lip type seal, a case is tightly fitted and fixed to an inner circumferential surface of a housing through a gasket. A resin lip member constituted by an inner circumferential part extending in a bent state from a diameter direction part and its inner circumference to a sealed space side and forming a seal surface between an outer circumferential part of a rotary shaft and the resin lip member; a rear surface support plate disposed to abut on a rear surface of the diameter direction part of the resin lip member; and a stopper with a rear surface supported to a support surface of the housing through a second resin lip member and a second rear surface support plate and the top end coming close to or coming into contact with a rear surface of the inner circumferential part of the rear surface support plate, are provided on the inner circumference of the housing.

摘要翻译： 在唇形密封件中，壳体通过垫圈紧密地装配并固定到壳体的内周面。 一种树脂唇形构件，由从直径方向部分和内周向弯曲状态延伸到密封空间侧的内周部分，并且在旋转轴的外圆周部分和树脂唇形构件之间形成密封面; 后表面支撑板，设置成邻接树脂唇形构件的直径方向部分的后表面; 以及具有通过第二树脂唇部件和第二后表面支撑板支撑在所述壳体的支撑表面上的后表面的止动件，并且所述顶端靠近或接触所述壳体的内周部分的后表面 后表面支撑板设置在壳体的内周上。

公开(公告)号：US07467797B2

公开(公告)日：2008-12-23

申请号：US10552063

申请日：2004-04-05

申请人： Koichiro Oiyama ,  Yasuhiro Ikeda ,  Hajime Ichiyasu ,  Ichiro Miyai ,  Takeshi Yamada ,  Masami Osako

发明人： Koichiro Oiyama ,  Yasuhiro Ikeda ,  Hajime Ichiyasu ,  Ichiro Miyai ,  Takeshi Yamada ,  Masami Osako

IPC分类号： F16J15/32

CPC分类号： F16J15/3228 ,  F16J15/3216

摘要： The lip-type seal of the present invention includes a seal ring made of an elastic material so as to have an annular fitted part that is fitted to a housing and a lip part that extends from the fitted part inwardly in a radial direction in the shape of a substantially conical ring and that is brought into contact with a shaft, and a support ring including an annular joint part joined to the fitted part and an annular supporting part that defines a hole through which the shaft passes, that extends from a side of the joint part to a halfway area of the lip part, and that supports the lip part from inside in a radial direction. The lip part is tapered in cross section from an area from which non-contact with the supporting part starts toward an end thereof.

摘要翻译： 本发明的唇型密封件包括由弹性材料制成的密封环，以具有嵌合到壳体的环形装配部分和从配合部分沿径向向内延伸的形状的唇形部分 基本上圆锥形的环并且与轴接触，并且支撑环包括连接到装配部分的环形接头部分和环形支撑部分，该环形支撑部分限定了轴穿过的孔，该环形支撑部分从 接合部分到唇部的中间部分，并且在径向方向上从内侧支撑唇部。 唇部从与支撑部非接触开始朝向其端部的区域的横截面呈锥形。

公开(公告)号：US10047346B2

公开(公告)日：2018-08-14

申请号：US13058154

申请日：2009-08-10

申请人： Yasuhiro Ikeda ,  Andre Terzic ,  Timothy J. Nelson ,  Amber A. Mael ,  Almudena J. Martinez Fernandez ,  Satsuki Yamada

发明人： Yasuhiro Ikeda ,  Andre Terzic ,  Timothy J. Nelson ,  Amber A. Mael ,  Almudena J. Martinez Fernandez ,  Satsuki Yamada

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N5/074 ,  A61K35/12

摘要： This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

公开(公告)号：US08866282B2

公开(公告)日：2014-10-21

申请号：US13586104

申请日：2012-08-15

申请人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

发明人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

IPC分类号： H01L23/52 ,  H04L25/02 ,  H05K1/02 ,  H01L49/02 ,  H01L23/12

CPC分类号： H01L28/20 ,  H01L23/12 ,  H01L23/5228 ,  H01L2224/16225 ,  H04L25/02 ,  H04L25/0272 ,  H04L25/0288 ,  H05K1/02 ,  H05K1/0234 ,  H05K1/0246 ,  H05K1/025 ,  H05K2201/10022 ,  H05K2201/10159

摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.

摘要翻译： 在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。 当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器） 负载电容，预加重不执行或略微执行。 由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃 数据传输速率提高。

公开(公告)号：US20130207234A1

公开(公告)日：2013-08-15

申请号：US13586104

申请日：2012-08-15

申请人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

发明人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

IPC分类号： H01L49/02

CPC分类号： H01L28/20 ,  H01L23/12 ,  H01L23/5228 ,  H01L2224/16225 ,  H04L25/02 ,  H04L25/0272 ,  H04L25/0288 ,  H05K1/02 ,  H05K1/0234 ,  H05K1/0246 ,  H05K1/025 ,  H05K2201/10022 ,  H05K2201/10159

摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.

摘要翻译： 在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。 当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器） 负载电容，预加重不执行或略微执行。 由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃 数据传输速率提高。

公开(公告)号：US08278284B2

公开(公告)日：2012-10-02

申请号：US11884738

申请日：2006-02-21

申请人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

发明人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

IPC分类号： A61K48/00 ,  A01N63/00 ,  C12P19/34

CPC分类号： A61K48/005 ,  A61K48/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6081

摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

摘要翻译： 本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。 本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。 本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。 当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。 因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

公开(公告)号：US08052153B2

公开(公告)日：2011-11-08

申请号：US12096600

申请日：2006-12-20

申请人： Hiroshi Ebihara ,  Yasuhisa Arita ,  Yasuhiro Ikeda

发明人： Hiroshi Ebihara ,  Yasuhisa Arita ,  Yasuhiro Ikeda

IPC分类号： F16J15/32

CPC分类号： F16J15/3232

摘要： [PROBLEMS] A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be sealed and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer.[MEANS FOR SOLVING PROBLEMS] A backup ring (2) has a tapered section (23) continuously extending from a fixation section (21) of the backup ring (2) and also has a forward end section (24). A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary (26) where a surface (D) of the tapered section (23) changes to a surface (F) of the forward end section (24). A portion of the surface (D) of the tapered surface (23), which portion is in contact with the rounded surface (E) at the boundary (26), is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary (26).

摘要翻译： 一种密封装置，其中密封唇相对于待密封的高压流体可靠地保持轴密封，并且其中在密封唇中发生的等效米塞斯应力减小，以延长密封唇的耐用期。 解决问题的手段备用环（2）具有从支撑环（2）的固定部（21）连续延伸的锥形部（23），并且还具有前端部（24）。 至少在锥形部分（23）的表面（D）变化到前端部分的表面（F）的边界（26）处形成具有曲率半径（R-1）的圆形表面（E） （24）。 锥形表面（23）的表面（D）的一部分在边界（26）处与圆形表面（E）接触的是曲率半径大于曲率半径的投影曲率表面（D） R-1）。

公开(公告)号：US20110226676A1

公开(公告)日：2011-09-22

申请号：US13131916

申请日：2010-05-31

申请人： Yasuhiro Ikeda

发明人： Yasuhiro Ikeda

IPC分类号： B07B1/22 ,  B07B1/46 ,  B07B1/20

CPC分类号： B07B1/22 ,  B07B1/24 ,  B07B1/4654 ,  B07B1/469 ,  B07B13/16

摘要： An integrally-rotating cylindrical sieve 1 includes a hollow rotating shaft 2, which a driveshaft 21 is inserted into and fixed to, support members 3 radially extended from the rotating shaft 2, a cylindrical sieve body 4 made from a thin plate with a large number of apertures 5 formed therein, such as punching metal, and coupled with the support members 3, and sieve frames 6a and 6b attached to axial ends of the sieve body 4. The rotating shaft 2, the support members 3, the sieve body 4, the sieve frames 6a and 6b, and the driveshaft 21 are coaxially rotated together. The sieve body 4 is a cylindrical corrugated plate having wave crests and wave troughs arranged along its circumference and has a large number of apertures 5 formed in the corrugated plate. This arrangement improves the sieving efficiency of the granular material and effectively prevents potential destruction and cracking of the granular material, thus enhancing the commercial value of the sieved granular material.

摘要翻译： 一体旋转的圆筒筛1包括中空旋转轴2，驱动轴21插入并固定到从旋转轴2径向延伸的支撑构件3，圆柱形筛体4由具有大量的薄板制成 形成在其中的孔5，例如冲孔金属，并且与支撑构件3相连，以及安装在筛体4的轴向端部的筛架6a和6b。旋转轴2，支撑构件3，筛体4， 筛架6a和6b以及驱动轴21同时旋转。 筛体4是具有沿着其圆周布置的波峰和波谷的圆柱形波纹板，并且在波纹板中形成有大量的孔5。 由此，能够提高粒状材料的筛分效率，有效地防止颗粒状物的潜在的破坏和破裂，从而提高筛分粒状材料的商业价值。