公开(公告)号：US08278284B2

公开(公告)日：2012-10-02

申请号：US11884738

申请日：2006-02-21

申请人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

发明人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

IPC分类号： A61K48/00 ,  A01N63/00 ,  C12P19/34

CPC分类号： A61K48/005 ,  A61K48/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6081

摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

摘要翻译： 本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。 本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。 本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。 当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。 因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

公开(公告)号：US20090233988A1

公开(公告)日：2009-09-17

申请号：US11884738

申请日：2006-02-21

申请人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

发明人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

IPC分类号： A61K31/711 ,  C12N15/63 ,  C12N7/01

CPC分类号： A61K48/005 ,  A61K48/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6081

摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

摘要翻译： 本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。 本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。 本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。 当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。 因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

公开(公告)号：US07309693B2

公开(公告)日：2007-12-18

申请号：US10276971

申请日：2001-05-25

申请人： Kensuke Egashira ,  Yoshikazu Yonemitsu ,  Katsuo Sueishi ,  Yasuhiro Ikeda ,  Yoshiyuki Inada

发明人： Kensuke Egashira ,  Yoshikazu Yonemitsu ,  Katsuo Sueishi ,  Yasuhiro Ikeda ,  Yoshiyuki Inada

IPC分类号： A61K31/70 ,  A01N43/04 ,  C12P19/34 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07K16/24 ,  A61K31/711 ,  A61K38/195 ,  A61K2039/505

摘要： The present invention provides a prophylactic and/or therapeutic agent for pulmonary hypertension, comprising an antagonistic mutein of MCP-1 or a salt thereof, a DNA molecule comprising a nucleotide sequence encoding the antagonistic mutein of MCP-1, or a neutralizing antibody against MCP-1. The antagonistic mutein of MCP-1 or a salt thereof, the DNA molecule having a nucleotide sequence encoding the antagonistic mutein of MCP-1, or the neutralizing antibody against MCP-1 has hypotensive activity, and thus is useful as a pharmaceutical agent for preventing and/or treating pulmonary hypertension (primary pulmonary hypertension, in particular).

摘要翻译： 本发明提供了一种肺动脉高压的预防和/或治疗剂，其包含MCP-1的拮抗性突变蛋白或其盐，包含编码MCP-1的拮抗性突变蛋白的核苷酸序列的DNA分子或针对MCP的中和抗体 -1。 MCP-1或其盐的拮抗性突变蛋白，具有编码MCP-1的拮抗性突变蛋白的核苷酸序列的DNA分子或针对MCP-1的中和抗体具有降血压活性，因此可用作预防药物 和/或治疗肺动脉高压（特别是原发性肺动脉高压）。

公开(公告)号：US10047346B2

公开(公告)日：2018-08-14

申请号：US13058154

申请日：2009-08-10

申请人： Yasuhiro Ikeda ,  Andre Terzic ,  Timothy J. Nelson ,  Amber A. Mael ,  Almudena J. Martinez Fernandez ,  Satsuki Yamada

发明人： Yasuhiro Ikeda ,  Andre Terzic ,  Timothy J. Nelson ,  Amber A. Mael ,  Almudena J. Martinez Fernandez ,  Satsuki Yamada

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N5/074 ,  A61K35/12

摘要： This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.

公开(公告)号：US08866282B2

公开(公告)日：2014-10-21

申请号：US13586104

申请日：2012-08-15

申请人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

发明人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

IPC分类号： H01L23/52 ,  H04L25/02 ,  H05K1/02 ,  H01L49/02 ,  H01L23/12

CPC分类号： H01L28/20 ,  H01L23/12 ,  H01L23/5228 ,  H01L2224/16225 ,  H04L25/02 ,  H04L25/0272 ,  H04L25/0288 ,  H05K1/02 ,  H05K1/0234 ,  H05K1/0246 ,  H05K1/025 ,  H05K2201/10022 ,  H05K2201/10159

摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.

摘要翻译： 在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。 当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器） 负载电容，预加重不执行或略微执行。 由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃 数据传输速率提高。

公开(公告)号：US20130207234A1

公开(公告)日：2013-08-15

申请号：US13586104

申请日：2012-08-15

申请人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

发明人： Yasuhiro Ikeda ,  Yutaka Uematsu ,  Satoshi Muraoka

IPC分类号： H01L49/02

CPC分类号： H01L28/20 ,  H01L23/12 ,  H01L23/5228 ,  H01L2224/16225 ,  H04L25/02 ,  H04L25/0272 ,  H04L25/0288 ,  H05K1/02 ,  H05K1/0234 ,  H05K1/0246 ,  H05K1/025 ,  H05K2201/10022 ,  H05K2201/10159

摘要： A slew rate of a signal transmitted between a semiconductor device having a small load capacitance and a semiconductor device having a large load capacitance is improved. When a signal is transmitted to the semiconductor device (for example, a memory device) having the large load capacitance, pre-emphasis is performed, and when a signal is transmitted to the semiconductor device (for example, a memory controller) having the small load capacitance, pre-emphasis is not performed or is slightly performed. By this, when the signal is transmitted to the memory device, blunting in signal rising due to the load capacitance is suppressed, and when the signal is transmitted to the memory controller, ringing due to the reflection of the signal is suppressed, and the slew rate of the data transmission is improved.

摘要翻译： 在具有小负载电容的半导体器件和具有大负载电容的半导体器件之间传输的信号的转换速率得到改善。 当信号被发送到具有大的负载电容的半导体器件（例如，存储器件）时，执行预加重，并且当信号被发送到具有小的负载电容的半导体器件（例如，存储器控制器） 负载电容，预加重不执行或略微执行。 由此，当信号被发送到存储装置时，由于负载电容而导致的信号上升的钝化被抑制，并且当信号被发送到存储器控制器时，由于信号的反射而被抑制的振铃 数据传输速率提高。

公开(公告)号：US08052153B2

公开(公告)日：2011-11-08

申请号：US12096600

申请日：2006-12-20

申请人： Hiroshi Ebihara ,  Yasuhisa Arita ,  Yasuhiro Ikeda

发明人： Hiroshi Ebihara ,  Yasuhisa Arita ,  Yasuhiro Ikeda

IPC分类号： F16J15/32

CPC分类号： F16J15/3232

摘要： [PROBLEMS] A seal device where a seal lip reliably maintains shaft sealing relative to high-pressure fluid that is to be sealed and where the equivalent Mises stress occurring in the seal lip is reduced to extend the durable term of the seal lip longer.[MEANS FOR SOLVING PROBLEMS] A backup ring (2) has a tapered section (23) continuously extending from a fixation section (21) of the backup ring (2) and also has a forward end section (24). A rounded surface (E) with a curvature radius (R-1) is formed at least at a boundary (26) where a surface (D) of the tapered section (23) changes to a surface (F) of the forward end section (24). A portion of the surface (D) of the tapered surface (23), which portion is in contact with the rounded surface (E) at the boundary (26), is a projected curvature surface having a curvature radius greater than the curvature radius (R-1) of the boundary (26).

摘要翻译： 一种密封装置，其中密封唇相对于待密封的高压流体可靠地保持轴密封，并且其中在密封唇中发生的等效米塞斯应力减小，以延长密封唇的耐用期。 解决问题的手段备用环（2）具有从支撑环（2）的固定部（21）连续延伸的锥形部（23），并且还具有前端部（24）。 至少在锥形部分（23）的表面（D）变化到前端部分的表面（F）的边界（26）处形成具有曲率半径（R-1）的圆形表面（E） （24）。 锥形表面（23）的表面（D）的一部分在边界（26）处与圆形表面（E）接触的是曲率半径大于曲率半径的投影曲率表面（D） R-1）。

公开(公告)号：US20110226676A1

公开(公告)日：2011-09-22

申请号：US13131916

申请日：2010-05-31

申请人： Yasuhiro Ikeda

发明人： Yasuhiro Ikeda

IPC分类号： B07B1/22 ,  B07B1/46 ,  B07B1/20

CPC分类号： B07B1/22 ,  B07B1/24 ,  B07B1/4654 ,  B07B1/469 ,  B07B13/16

摘要： An integrally-rotating cylindrical sieve 1 includes a hollow rotating shaft 2, which a driveshaft 21 is inserted into and fixed to, support members 3 radially extended from the rotating shaft 2, a cylindrical sieve body 4 made from a thin plate with a large number of apertures 5 formed therein, such as punching metal, and coupled with the support members 3, and sieve frames 6a and 6b attached to axial ends of the sieve body 4. The rotating shaft 2, the support members 3, the sieve body 4, the sieve frames 6a and 6b, and the driveshaft 21 are coaxially rotated together. The sieve body 4 is a cylindrical corrugated plate having wave crests and wave troughs arranged along its circumference and has a large number of apertures 5 formed in the corrugated plate. This arrangement improves the sieving efficiency of the granular material and effectively prevents potential destruction and cracking of the granular material, thus enhancing the commercial value of the sieved granular material.

摘要翻译： 一体旋转的圆筒筛1包括中空旋转轴2，驱动轴21插入并固定到从旋转轴2径向延伸的支撑构件3，圆柱形筛体4由具有大量的薄板制成 形成在其中的孔5，例如冲孔金属，并且与支撑构件3相连，以及安装在筛体4的轴向端部的筛架6a和6b。旋转轴2，支撑构件3，筛体4， 筛架6a和6b以及驱动轴21同时旋转。 筛体4是具有沿着其圆周布置的波峰和波谷的圆柱形波纹板，并且在波纹板中形成有大量的孔5。 由此，能够提高粒状材料的筛分效率，有效地防止颗粒状物的潜在的破坏和破裂，从而提高筛分粒状材料的商业价值。

公开(公告)号：US07344140B2

公开(公告)日：2008-03-18

申请号：US10542751

申请日：2004-01-30

申请人： Yasuhiro Ikeda

发明人： Yasuhiro Ikeda

IPC分类号： F16J15/32

CPC分类号： F16J15/3268 ,  F16J15/3228 ,  F16J15/3276

摘要： The lip-type seal of the present invention is a lip-type seal with which the outer periphery of a rotational shaft (S) supported by a predetermined housing (H) is sealed. The lip-type seal is made up of a first annular reinforcing member (11) and a first sealing member (12). The first reinforcing member (11) includes a wall surface part (11a) defining a hole through which the rotational shaft (S) is passed and a cylindrical part (11b) bent from the outer edge of the wall surface part (11a). The first sealing member (12) includes an annular base (12a) that is joined to the housing (H), a first lip part (12b) that extends almost conical from the base (12a) inwardly in the radial direction and that comes into contact with the rotational shaft (S), and an annular concave part (11c) formed on the base (12a) so as to detachably fit the cylindrical part (11b). Accordingly, a desired sealing capability can be secured, and the components can be easily assembled, disassembled, and recycled.

摘要翻译： 本发明的唇形密封件是密封由预定壳体（H）支撑的旋转轴（S）的外周的唇型密封件。 唇形密封件由第一环形加强件（11）和第一密封件（12）构成。 第一加强构件（11）包括限定旋转轴（S）穿过的孔的壁表面部分（11a）和从壁表面部分（11a）的外边缘弯曲的圆柱形部分（11b） ）。 第一密封构件（12）包括连接到壳体（H）的环形基部（12a），从基部（12a）沿径向向内延伸大致圆锥形的第一唇部（12b） 与所述旋转轴（S）接触的环形凹部（11c），以及形成在所述基部（12a）上的环状凹部（11c），以便可拆卸地装配所述圆筒部（11b）。 因此，可以确保期望的密封能力，并且可以容易地组装，拆卸和再循环组件。

公开(公告)号：US5369826A

公开(公告)日：1994-12-06

申请号：US60997

申请日：1993-05-14

申请人： Yasuhiro Ikeda

发明人： Yasuhiro Ikeda

IPC分类号： A47C20/04 ,  A47C23/00 ,  A47C31/12 ,  A61G7/04

CPC分类号： A47C31/123 ,  A47C20/04 ,  A47C23/005

摘要： A bottom structure of a bed having a bottom formed so as to be bendable by a series of parallel strips mutually sequentially connected such that the strips are shorter in width on the side away from the sequentially connected side. In this way the bottom structure of the bed allows a portion of a bed bottom to be bent in a large curvature, thus is provided a bed which is comfortable and highly adaptable for patients of various body sizes.

摘要翻译： 床的底部结构，其底部形成为可以通过相互顺序连接的一系列平行条弯曲，使得条在远离顺序连接的一侧的宽度上较短。 以这种方式，床的底部结构允许床底部的一部分以大的曲率弯曲，因此提供了舒适的床，并且适用于各种身体尺寸的患者。