公开(公告)号：US08278284B2

公开(公告)日：2012-10-02

申请号：US11884738

申请日：2006-02-21

申请人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

发明人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

IPC分类号： A61K48/00 ,  A01N63/00 ,  C12P19/34

CPC分类号： A61K48/005 ,  A61K48/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6081

摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

摘要翻译： 本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。 本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。 本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。 当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。 因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

公开(公告)号：US20090233988A1

公开(公告)日：2009-09-17

申请号：US11884738

申请日：2006-02-21

申请人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

发明人： Masanori Miyazaki ,  Yoshikazu Yonemitsu ,  Yasuhiro Ikeda ,  Katsuo Sueishi ,  Toshiaki Tabata ,  Akihiro Iida ,  Yasuji Ueda ,  Mamoru Hasegawa

IPC分类号： A61K31/711 ,  C12N15/63 ,  C12N7/01

CPC分类号： A61K48/005 ,  A61K48/00 ,  C07K14/475 ,  C12N15/86 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2810/6081

摘要： The present invention provides novel methods for treating diseases associated with apoptotic degeneration in ocular tissue cells by effective administration of pigment epithelium derived factor (PEDF). The present inventors studied PEDF as a means to prevent ganglion cell death, the final pathology of glaucoma. The present invention is particularly focused on SIV vectors for effective methods for delivering PEDF, and constructed an SIV-PEDF vector. When the SIV-PEDF vector was administered subretinally to an ischemia reperfusion model and NMDA-induced model, a significant suppression effect on ganglion cell death was observed. The present inventors therefore discovered that the SIV-PEDF vector is an effective pharmaceutical agent for treating diseases associated with apoptotic degeneration in ocular tissue cells, such as glaucoma.

摘要翻译： 本发明提供了通过有效施用色素上皮衍生因子（PEDF）来治疗与眼组织细胞凋亡变性相关的疾病的新方法。 本发明人研究了PEDF作为预防神经节细胞死亡，青光眼的最终病理学的手段。 本发明特别关注用于递送PEDF的有效方法的SIV载体，并构建了SIV-PEDF载体。 当将SIV-PEDF载体视觉上给予缺血再灌注模型和NMDA诱导的模型时，观察到对神经节细胞死亡的显着抑制作用。 因此本发明人发现SIV-PEDF载体是用于治疗与眼组织细胞如青光眼中凋亡变性相关的疾病的有效药剂。

公开(公告)号：US5446646A

公开(公告)日：1995-08-29

申请号：US851782

申请日：1992-03-16

申请人： Masanori Miyazaki

发明人： Masanori Miyazaki

IPC分类号： H02M7/219 ,  H02M7/48 ,  H02M7/757 ,  H02M7/797

CPC分类号： H02M7/219

摘要： A control method for a PWM converter which is connected to an AC current source via a reactor, and performs the sending and receiving of power between the AC power source and a DC power source, includes a step of separating a supplied AC current into an effective current and a reactive current and performing PWM control and a step for control so that said reactive current is larger when there is conversion of DC power into AC power, than when there is conversion of an AC power into DC power. In addition, the control apparatus includes a detector element which detects at least two phases of a three-phase AC current as a current detection value, a phase detection element which detects a voltage phase of the three-phase current, a current separation element which uses the voltage phase to separate the detected current detection value into an effective current and a reactive current, an effective current control element which performs feedback control so that the separated effective current becomes a required value, a reactive current control element which performs feedback control so that the separated reactive current becomes a required value, and a reference calculation element which calculates a reference value so that an reference value of a reactive current becomes larger for when the effective current and power voltage are of opposite polarities, than for when they are of the same polarity.

摘要翻译： 一种PWM转换器的控制方法，其经由电抗器连接到AC电流源，并且在AC电源和DC电源之间执行电力的发送和接收，包括将所提供的AC电流分离成有效的步骤 电流和无功电流，并且执行PWM控制和控制步骤，使得当将DC电力转换成AC电力时，与将AC电力转换为DC电力时相比，所述无功电流较大。 另外，控制装置具有检测作为电流检测值的三相交流电流的至少两相的检测元件，检测三相电流的电压相位的相位检测元件， 使用电压相位将检测到的电流检测值分离成有效电流和无功电流，执行反馈控制使得分离的有效电流成为所需值的有效电流控制元件，执行反馈控制的无功电流控制元件 分离的无功电流成为所需值，以及参考运算单元，其计算参考值，使得当有效电流和功率电压具有相反的极性时，无功电流的基准值变大， 相同的极性。

公开(公告)号：US5755938A

公开(公告)日：1998-05-26

申请号：US556188

申请日：1995-11-09

申请人： Hirofumi Fukui ,  Masanori Miyazaki ,  Masami Aihara ,  Chisato Iwasaki ,  Koichi Fukuda ,  Yasuhiko Kasama

发明人： Hirofumi Fukui ,  Masanori Miyazaki ,  Masami Aihara ,  Chisato Iwasaki ,  Koichi Fukuda ,  Yasuhiko Kasama

IPC分类号： H01L21/205 ,  C23C14/34 ,  C23C16/02 ,  C23C16/44 ,  C23C16/509 ,  H01L21/203 ,  H01L21/31 ,  H01L21/336 ,  H01L21/77 ,  H01L31/20 ,  C23C16/00

CPC分类号： H01L29/66765 ,  C23C14/34 ,  C23C16/0245 ,  C23C16/4405 ,  C23C16/5096 ,  H01J37/34 ,  H01L31/202 ,  H01J2237/32 ,  H01L27/1214 ,  Y02E10/50 ,  Y02P70/521

摘要： An apparatus which allows a first film to be formed on a substrate by chemical vapor deposition (CVD) and a second film to be formed on the substrate by sputtering, wherein the processes are performed sequentially in the same deposition chamber without exposing the substrate to an oxidative atmosphere. The deposition chamber includes a first electrode and a second electrode located under the first electrode. A transfer mechanism loads a dummy target onto the first electrode and the substrate onto the second electrode prior to a CVD process. The dummy target is resistant to sputtering and thus does not contaminate the film deposited on the substrate during CVD. After CVD and prior to sputtering, the transfer mechanism unloads the dummy target and replaces it with a sputtering target for film formation by sputtering. Both the dummy target and sputtering target can be loaded and unloaded from a single pressurized storage chamber. Thus, film formation by both sputtering and CVD can be accomplished by using a single deposition chamber without removing the substrate between processes.

摘要翻译： 一种允许通过化学气相沉积（CVD）在衬底上形成第一膜和通过溅射形成在衬底上的第二膜的装置，其中在相同的沉积室中顺序地进行处理，而不将衬底暴露于 氧化气氛。 沉积室包括位于第一电极下方的第一电极和第二电极。 转移机构在CVD工艺之前将虚拟靶加载到第二电极上的第一电极和衬底上。 虚拟靶对溅射是耐受的，因此在CVD期间不会污染沉积在衬底上的膜。 在CVD之后并且在溅射之前，转移机构卸载虚拟靶并用用溅射的成膜溅射靶代替它。 虚拟靶和溅射靶都可以从单个加压储存室装载和卸载。 因此，通过溅射和CVD的成膜可以通过使用单个沉积室而不在工艺之间移除基板来实现。

公开(公告)号：US5573958A

公开(公告)日：1996-11-12

申请号：US338713

申请日：1994-11-14

申请人： Hirofumi Fukui ,  Masanori Miyazaki ,  Hitoshi Seki ,  Makoto Sasaki ,  Yasuhiko Kasama

发明人： Hirofumi Fukui ,  Masanori Miyazaki ,  Hitoshi Seki ,  Makoto Sasaki ,  Yasuhiko Kasama

IPC分类号： G02F1/136 ,  G02F1/1362 ,  G02F1/1368 ,  H01L21/336 ,  H01L21/77 ,  H01L21/84 ,  H01L29/78 ,  H01L29/786 ,  H01L29/784

CPC分类号： G02F1/13458 ,  G02F1/1362 ,  H01L27/124 ,  H01L27/1259 ,  H01L29/66765

摘要： A method of fabricating a thin film transistor of an inverted stagger structure having a gate terminal, a gate insulator a semiconductor film, a source electrode and a drain electrode formed in that order; a gate terminal and a gate wiring are provided for supplying a scanning signal to the gate electrode; and a source terminal and a source wiring are provided for supplying a data signal to the source electrode, wherein the gate terminal is formed on an upper side of the gate insulating film and electrically connected to the gate wiring through a contact hole formed in the gate insulator.

摘要翻译： 一种制造具有栅极端子，栅绝缘体，半导体膜，源电极和漏电极的反交错结构的薄膜晶体管的方法，该反向交错结构以该顺序形成。 栅极端子和栅极布线用于向栅电极提供扫描信号; 并且提供源极端子和源极布线用于向源电极提供数据信号，其中栅极端子形成在栅极绝缘膜的上侧，并通过形成在栅极中的接触孔电连接到栅极布线 绝缘子。

公开(公告)号：US5550091A

公开(公告)日：1996-08-27

申请号：US437606

申请日：1995-05-09

申请人： Koichi Fukuda ,  Tomofumi Oba ,  Masanori Miyazaki ,  Hirofumi Fukui ,  Chisato Iwasaki ,  Yasuhiko Kasama ,  Tadahiro Ohmi ,  Masaru Kubota ,  Hitoshi Kitagawa ,  Akira Nakano ,  Osamu Yoshida

发明人： Koichi Fukuda ,  Tomofumi Oba ,  Masanori Miyazaki ,  Hirofumi Fukui ,  Chisato Iwasaki ,  Yasuhiko Kasama ,  Tadahiro Ohmi ,  Masaru Kubota ,  Hitoshi Kitagawa ,  Akira Nakano ,  Osamu Yoshida

IPC分类号： C23C14/06 ,  H01L21/02 ,  H01L21/28 ,  H01L21/31 ,  H01L21/318 ,  H01L21/331 ,  H01L21/336

CPC分类号： C23C14/0652 ,  H01L21/0217 ,  H01L21/02211 ,  H01L21/02274 ,  H01L21/28008 ,  H01L21/3185 ,  H01L28/40 ,  H01L29/66765

摘要： There is provided an electronic device like a TFT using a silicon nitride insulating film of a single layer structure having an excellent dielectric voltage, and a method of producing the electronic device with reliability. In the electronic device, a conductive wiring pattern is deposited on a surface of an electrically insulated substrate, and an insulating layer is formed to cover the wiring pattern and the substrate. The insulating layer is made of a silicon nitride insulating film. A contact angle .theta. between the wiring pattern and the substrate is equals 60.degree. or more, and a value Tn1/Tg of a thickness Tn1 of the silicon nitride insulating film and a thickness Tg of the wiring pattern equals 2 or more. A horizontal distance Tn2 between a rise start position, where the silicon nitride film rises because of a step of the wiring pattern and the top end of the wiring pattern, and Tn1 are in a relation where 0.6.ltoreq.Tn2/Tn1.

摘要翻译： 提供了一种使用具有优异的介电电压的单层结构的氮化硅绝缘膜的TFT的电子器件，以及可靠地制造该电子器件的方法。 在电子设备中，在电绝缘基板的表面上沉积导电布线图案，并且形成绝缘层以覆盖布线图案和基板。 绝缘层由氮化硅绝缘膜制成。 布线图案和基板之间的接触角θ等于60°以上，氮化硅绝缘膜的厚度Tn1的值Tn1 / Tg和布线图案的厚度Tg等于2以上。 由于布线图案的台阶和布线图案的上端而形成的氮化硅膜的上升起始位置和Tn1之间的水平距离Tn2为0.6

公开(公告)号：US6075299A

公开(公告)日：2000-06-13

申请号：US247807

申请日：1999-02-11

申请人： Masanori Miyazaki ,  Hirotaka Ono ,  Masaru Yamamoto

发明人： Masanori Miyazaki ,  Hirotaka Ono ,  Masaru Yamamoto

IPC分类号： H02K7/10 ,  H02K7/08 ,  H02K7/14 ,  H02K11/00 ,  H02K13/00

CPC分类号： H02K7/14 ,  H02K11/01 ,  H02K11/40 ,  H02K7/08

摘要： A motor drive system comprises a motor driven by a variable frequency power supply and a machine driven by the motor, which are mechanically connected by the drive shaft of the motor and the shaft of the machine via bearings. A stationary portion of the motor and the frame of the machine are electrically connected by a low-impedance conductor, so that a current can be caused to flow at least partially between the stationary portion of the motor and the frame of the machine.

摘要翻译： 电动机驱动系统包括由变频电源驱动的电动机和由电动机驱动的机器，其通过轴承通过电动机的驱动轴和机器的轴机械连接。 电动机的静止部分和机器的框架通过低阻抗导体电连接，使得可以使电流至少部分地在电机的固定部分和机器的框架之间流动。

公开(公告)号：US5609737A

公开(公告)日：1997-03-11

申请号：US289713

申请日：1994-08-12

申请人： Hirofumi Fukui ,  Masanori Miyazaki ,  Masami Aihara ,  Chisato Iwasaki ,  Koichi Fukuda ,  Yasuhiko Kasama

发明人： Hirofumi Fukui ,  Masanori Miyazaki ,  Masami Aihara ,  Chisato Iwasaki ,  Koichi Fukuda ,  Yasuhiko Kasama

IPC分类号： H01L21/205 ,  C23C14/34 ,  C23C16/02 ,  C23C16/44 ,  C23C16/509 ,  H01L21/203 ,  H01L21/31 ,  H01L21/336 ,  H01L21/77 ,  H01L31/20 ,  C23C16/00

CPC分类号： H01L29/66765 ,  C23C14/34 ,  C23C16/0245 ,  C23C16/4405 ,  C23C16/5096 ,  H01J37/34 ,  H01L31/202 ,  H01J2237/32 ,  H01L27/1214 ,  Y02E10/50 ,  Y02P70/521

摘要： A method for manufacturing thin films in which a first film is formed on a substrate using chemical-vapor deposition (CVD), and a second film is formed on the substrate using sputtering, wherein the processes are sequentially performed in the same deposition chamber without exposing the substrate to an oxidative atmosphere. The deposition chamber includes a first electrode, and a second electrode located under the first electrode. During the CVD process, a dummy target is mounted on the first electrode and the substrate is mounted on the second electrode, a reactive gas is introduced into the chamber, and high frequency electrical power is applied to both the first and second electrodes, thereby causing the constituents of the reactive gas to deposit on the substrate to form the first film. Subsequently, any remaining reactive gas is removed from the chamber and an automated mechanism removes the dummy target from the first electrode and stores the dummy target in a storage chamber. A sputtering electrode is then mounted on the first electrode and a sputtering gas is introduced into the reaction chamber. High frequency electrical power is then applied to both the first and second electrodes, thereby causing the sputtering gas and sputtering target to deposit the second film on the substrate.

摘要翻译： 一种用于制造薄膜的方法，其中使用化学气相沉积（CVD）在基板上形成第一膜，并且使用溅射在所述基板上形成第二膜，其中所述工艺在相同的沉积室中依次进行而不暴露 底物转化为氧化性气氛。 沉积室包括第一电极和位于第一电极下方的第二电极。 在CVD工艺期间，将虚拟目标物安装在第一电极上，并且将基板安装在第二电极上，将反应性气体引入室中，并且将高频电力施加到第一和第二电极两者，由此引起 反应气体的成分沉积在基底上以形成第一膜。 随后，将任何剩余的反应气体从室中除去，并且自动化机构从第一电极移除虚设目标物并将虚拟目标物存储在储存室中。 然后将溅射电极安装在第一电极上，并将溅射气体引入反应室。 然后将高频电力施加到第一和第二电极，由此使溅射气体和溅射靶将第二膜沉积在基板上。

公开(公告)号：US5387855A

公开(公告)日：1995-02-07

申请号：US42405

申请日：1993-04-02

申请人： Masanori Miyazaki ,  Yasuhiro Suzuki ,  Tadashi Saito

发明人： Masanori Miyazaki ,  Yasuhiro Suzuki ,  Tadashi Saito

IPC分类号： H02P21/00 ,  H02P5/40

CPC分类号： H02P21/00

摘要： In order to carry out commercial synchronous exchange for disconnecting an induction motor from its driving power supply and connecting it to a variable frequency power supply, or commercial synchronous switching for disconnecting the induction motor from the variable frequency power supply and connecting it to a commercial power supply, without any accompanying adverse shock, an induction-motor vector control technique is utilized. A phase-locked loop (PLL) is formed to detect the difference in phase between the output voltage from the variable frequency power supply or the magnetic flux phase of the induction motor on the one hand, and the phase of the power supply voltage on the other, so that the difference in phase thus detected can be maintained at a predetermined value.

摘要翻译： 为了进行用于将感应电动机与其驱动电源断开并将其连接到可变频率电源的商业同步交换，或用于将感应电动机与变频电源断开并将其连接到商业电力的商业同步开关 供应，没有任何伴随的不利冲击，使用感应电动机矢量控制技术。 形成锁相环（PLL）以一方面检测来自变频电源的输出电压或感应电动机的磁通相位之间的相位差，以及电源电压的相位 另一方面，使得如此检测的相位差可以保持在预定值。

公开(公告)号：US5212438A

公开(公告)日：1993-05-18

申请号：US873711

申请日：1992-04-22

申请人： Masanori Miyazaki ,  Yasuhiro Suzuki ,  Tadashi Saito

发明人： Masanori Miyazaki ,  Yasuhiro Suzuki ,  Tadashi Saito

IPC分类号： H02P21/00

CPC分类号： H02P21/00

摘要： In order to carry out commercial synchronous exchange for disconnecting an induction motor from its driving power supply and connecting it to a variable frequency power supply or commercial synchronous switching for disconnecting the induction motor from the variable frequency power supply and connecting it to a commercial power supply without any accompanying adverse shock, an induction-motor vector control technique is utilized and furthermore, a phase-locked loop (PLL) is formed to detect the difference in phase between the phase of the output voltage from the variable frequency power supply or the magnetic flux phase of the induction motor on the one hand, and the phase of the voltage of the power supply on the other, so that the difference in phase thus detected can be maintained at a predetermined value.

摘要翻译： 为了进行商业同步交换，以将感应电动机与其驱动电源断开并将其连接到变频电源或商用同步开关，用于将感应电动机与变频电源断开并将其连接到商用电源 没有任何伴随的不利冲击，利用感应电动机矢量控制技术，此外，形成锁相环（PLL）以检测来自可变频率电源或磁场的输出电压的相位之间的相位差 一方面是感应电动机的通量相位，另一方面是电源电压的相位，使得这样检测的相位差可以保持在预定值。