公开(公告)号：US06649894B2

公开(公告)日：2003-11-18

申请号：US10150937

申请日：2002-05-21

申请人： Takuya Matsumoto ,  Masashi Kiguchi ,  Hirofumi Sukeda

发明人： Takuya Matsumoto ,  Masashi Kiguchi ,  Hirofumi Sukeda

IPC分类号： G02B704

CPC分类号： G01Q60/22 ,  G11B7/0937

摘要： An optical near field probe of high resolution and high efficiency is disclosed. A near field light is generated using a tapered, plane scatterer formed on a substrate surface. The intensity of the near field light is enhanced by making the area of the scatterer smaller than that of a light spot and by selecting the material, shape, and size of the scatterer so as to generate plasmon resonance. An optical near field generator having a high light utilization efficiency can be obtained.

摘要翻译： 公开了一种高分辨率，高效率的光学近场探头。 使用形成在基板表面上的锥形平面散射体产生近场光。 通过使散射体的面积小于光斑的面积，并且通过选择散射体的材料，形状和尺寸，以产生等离子体共振来增强近场光的强度。 可以获得具有高光利用效率的光学近场发生器。

公开(公告)号：US06949732B2

公开(公告)日：2005-09-27

申请号：US10046249

申请日：2002-01-16

申请人： Masashi Kiguchi ,  Takuya Matsumoto ,  Tomohiro Hashizume ,  Isamu Orita

发明人： Masashi Kiguchi ,  Takuya Matsumoto ,  Tomohiro Hashizume ,  Isamu Orita

IPC分类号： G01Q10/00 ,  G01Q60/18 ,  G01Q60/22 ,  G01Q70/06 ,  G01Q80/00 ,  G11B7/135 ,  H01J3/14 ,  G02F1/00

CPC分类号： G01Q60/22

摘要： Optical apparatuses are provided that use near-field light, where high spatial resolution and high sensitivity are made compatible. Highly intense near-field light is generated in a narrow area using localized plasmons that are produced in a metal pattern 106 in a shape that bears anisotropy and is made to irradiate a measured subject. The direction of polarization 104 of incident light 103 is modulated and signal light is subjected to synchronous detection, so that background light is removed and high sensitivity is achieved.

摘要翻译： 提供使用能够兼容高空间分辨率和高灵敏度的近场光的光学装置。 使用以金属图案106制造的局部等离子体，在狭窄的区域中产生高度强烈的近场光，其具有各向异性的形状并且被照射到被测量的对象。 调制入射光103的偏振方向104，对信号光进行同步检测，消除背景光，实现高灵敏度。

公开(公告)号：US09706955B2

公开(公告)日：2017-07-18

申请号：US14408644

申请日：2012-06-21

申请人： Hirokazu Atsumori ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Masashi Kiguchi

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/145 ,  G06N5/04 ,  A61B5/16

CPC分类号： A61B5/14553 ,  A61B5/14546 ,  A61B5/14552 ,  A61B5/165 ,  A61B5/486 ,  A61B5/7225 ,  A61B5/7246 ,  A61B5/7278 ,  A61B5/742 ,  A61B5/743 ,  A61B5/7435 ,  A61B5/7475 ,  A61B2505/09 ,  A61B2560/0475 ,  A61B2562/0238 ,  G06N5/04

摘要： Provided is a biological state assessment device for assessing biological state, such as mood or emotions, using non-invasive biophotonic measurement technology. The present invention includes a light irradiation unit (1041), a light-receiving unit (1061), and an inputting means (112). A subject (800) is presented with a plurality of different problems (first problem, second problem), and a biological signal in the interior of the subject is calculated from the intensity of light received by the light-receiving unit (1061). Subjective information about the subject is accepted by the inputting means (112). The difference is calculated between the subjective information and the relative value of the biological signal of the measurement point for the first problem and the biological signal of the measurement point for the second problem, and the result is displayed.

公开(公告)号：US07285790B2

公开(公告)日：2007-10-23

申请号：US11044040

申请日：2005-01-28

申请人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

发明人： Naoki Tanaka ,  Takusige Katura ,  Masashi Kiguchi ,  Hiroki Sato ,  Atsushi Maki

IPC分类号： A61B5/00

CPC分类号： A61B5/16 ,  A61B5/14553 ,  A61B5/6814

摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.

摘要翻译： 响应时间是任意确定的。 由于信号中包含的伪影等，不能提供令人满意的检测能力。 因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。 使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。 测量信号的相位与参考信号的相位的同步性被数字表示。 对这样得到的数值进行统计处理，以便数值地表达可靠度。 因此，大脑活动或功能连接可视化。

公开(公告)号：US20070106139A1

公开(公告)日：2007-05-10

申请号：US11317002

申请日：2005-12-27

申请人： Koji Nagata ,  Hiroshi Mitsumaki ,  Tsuyoshi Uchida ,  Rinichi Asano ,  Masashi Kiguchi

发明人： Koji Nagata ,  Hiroshi Mitsumaki ,  Tsuyoshi Uchida ,  Rinichi Asano ,  Masashi Kiguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/01 ,  A61B5/14532 ,  A61B5/1491

摘要： Measurement of blood flow rate in a convenient manner has been enabled by using a simple device constitution and a simple signal processing technique. A measurement mechanism having both the function of measuring temperature of the measurement site and the function of applying a thermal load to the measurement site is used, and a process of extracting temperature change associated with the recovery of the surface temperature by the blood flow is conducted from the measurement results obtained by the measurement mechanism.

摘要翻译： 通过使用简单的装置结构和简单的信号处理技术，能够以便利的方式测量血液流量。 使用具有测量部位的温度的功能和对测量部位施加热负荷的功能的测量机构，并且进行与通过血流回收表面温度相关的温度变化的处理 从测量机构获得的测量结果。

公开(公告)号：US07022083B2

公开(公告)日：2006-04-04

申请号：US10457478

申请日：2003-06-10

申请人： Naoki Tanaka ,  Atsushi Maki ,  Masashi Kiguchi

发明人： Naoki Tanaka ,  Atsushi Maki ,  Masashi Kiguchi

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/486 ,  A61B5/0086 ,  A61B5/1455

摘要： A satisfactory averaged signal can be obtained with only a small number of repetitions of measurement in the measurement of responses to a stimulus given to a living body. A low-frequency biological fluctuation is extracted and a stimulus is presented to the living body in synchronism with the phase of the extracted fluctuation.

摘要翻译： 在对给予生物体的刺激的响应的测量的测量中，可以仅获得少量的测量重复来获得满意的平均信号。 提取低频生物波动，并且与提取的波动的相位同步地向生物体提供刺激。

公开(公告)号：US20140107439A1

公开(公告)日：2014-04-17

申请号：US14117154

申请日：2012-06-15

申请人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

发明人： Hirokazu Atsumori ,  Hiroki Sato ,  Masashi Kiguchi

IPC分类号： A61B5/16 ,  A61B5/1455

CPC分类号： A61B5/165 ,  A61B5/14551

摘要： Disclosed is a device using a biological optical measurement technology to evaluate mood states in daily life of an examinee by presenting a first task once or a plurality of times and then presents a second task a plurality of times, calculating a hemoglobin signal of a predetermined measurement point for the first task and a hemoglobin signal of a predetermined measurement point for the second task, and calculating quantitative values using the obtained hemoglobin signals.

摘要翻译： 公开了一种使用生物光学测量技术的装置，通过呈现第一任务一次或多次来评估受试者的日常生活中的情绪状态，然后多次呈现第二任务，计算预定测量的血红蛋白信号 指定第一任务和第二任务的预定测量点的血红蛋白信号，以及使用获得的血红蛋白信号计算定量值。

公开(公告)号：US07974671B2

公开(公告)日：2011-07-05

申请号：US10572357

申请日：2004-09-03

申请人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

发明人： Michiyuki Fujiwara ,  Tsuneaki Kawaguchi ,  Fumio Kawaguchi ,  Shingo Kawasaki ,  Atsushi Maki ,  Yukiko Hirabayashi ,  Yukari Yamamoto ,  Masashi Kiguchi ,  Hiroki Sato ,  Tsuyoshi Yamamoto ,  Takushige Katsura ,  Hideo Kawaguchi

IPC分类号： A61B5/00

CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0059 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/0484 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/6822 ,  A61B5/742 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/046

摘要： A living body information signal processing system (100) combining organically a living body optical measurement apparatus and a brain wave measurement apparatus, the living body optical measurement apparatus (300) in which inspection light of from visible to near infrared is irradiated on a head portion of a subject (140) and the penetration light is received and which measures an optical characteristic variation induced by a brain activity inside the head portion as a living body optical signal and the brain wave measurement apparatus (400) which measures an electrical characteristic variation induced by a brain activity inside the head portion of the subject as a brain wave signal, is provided with a probe device (50) used for both apparatus; and a living body information signal processing and displaying device (200) which displays the living body optical signal corresponding to respective measurement positions from the living body optical measurement apparatus and the brain wave signal corresponding to respective measurement positions from the brain wave measurement apparatus on a common display device while correlating the respective measurement positions each other, thereby, with the system comprehensive observation of both data can be achieved.

摘要翻译： 一种生物体信息信号处理系统（100），其组织有机地生物体光学测量装置和脑电波测定装置，所述生物体光学测量装置（300）将从所述可见光到近红外线的检查光照射在头部 并且测量由头部内部的脑活动引起的作为生物体光信号的光学特性变化和测量电特性变化的脑波测量装置（400）的穿透光， 通过作为脑波信号的被检体头部内的脑活动，设置有用于两个装置的探针装置（50）; 以及生物体信息信号处理和显示装置（200），其从来自所述生物体光学测量装置的对应于各测量位置的生物体光信号和对应于来自所述脑波测量装置的各测量位置的脑波信号 共同显示装置，同时将各个测量位置相互关联，从而可以实现对两个数据的系统综合观察。

公开(公告)号：US07516021B2

公开(公告)日：2009-04-07

申请号：US11570558

申请日：2005-06-08

申请人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

发明人： Hiroki Sato ,  Atsushi Maki ,  Tsuyoshi Yamamoto ,  Masashi Kiguchi

IPC分类号： G01N31/00

CPC分类号： A61B5/7264 ,  A61B5/0059 ,  A61B5/7425 ,  A61B5/743 ,  G06F19/00 ,  G16H40/63

摘要： Apparatus and method for hemoglobin measurement including irradiating light to a living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; irradiating light to the living body, detecting light that has propagated through the living body, and acquiring measured data that represents a change in the concentration of oxidized hemoglobin in the living body and a change in the concentration of deoxidized hemoglobin; classifying the data measured at the first step and the data measured at the second step according to each of an increase or a decrease in the concentration of oxidized hemoglobin and an increase or a decrease in the concentration of deoxidized hemoglobin; and displaying the classifications determined at the third step.

摘要翻译： 用于血红蛋白测量的装置和方法，包括向生物体照射光，检测通过活体传播的光，并获取表示生物体中氧化血红蛋白浓度变化的测量数据和脱氧浓度变化 血红蛋白 对生物体照射光，检测通过生物体传播的光，获取表示生物体中氧化血红蛋白浓度变化的测定数据和脱氧血红蛋白浓度的变化; 根据氧化血红蛋白浓度的增加或减少以及脱氧血红蛋白浓度的增加或减少，分别在第一步骤测量的数据和在第二步骤测量的数据; 并显示在第三步确定的分类。

公开(公告)号：US20080259337A1

公开(公告)日：2008-10-23

申请号：US11944064

申请日：2007-11-21

申请人： Kazuhiko SAGARA ,  Yukio Kumagai ,  Naoki Matsushima ,  Masashi Kiguchi

发明人： Kazuhiko SAGARA ,  Yukio Kumagai ,  Naoki Matsushima ,  Masashi Kiguchi

IPC分类号： G01N21/00

CPC分类号： A61B5/0261 ,  A61B5/6814 ,  A61B2560/0252 ,  A61B2562/0233 ,  A61B2562/046

摘要： A cerebral function measuring apparatus houses a light detector in a package that can be set on the head of the subject examinee with light detection elements, amplifiers, and high voltage power supplies sealed in the package. Each amplifier and each high voltage power supply are united into one and covered with a high polymer material with high dielectric strength, and further enclosed by a metallic shield so as to be insulated. The high voltage power supply consists of a very small coil and an integrated circuit to generate a voltage required to drive the light detection element in the package. A removable and safe module type light detector is thus realized.

摘要翻译： 大脑功能测量装置容纳包装中的光检测器，该检测器可以被封装在被检体内的光检测元件，放大器和高压电源上。 每个放大器和每个高压电源组合成一个并覆盖有高介电强度的高聚合物材料，并进一步用金属屏蔽物封闭以便被绝缘。 高压电源由非常小的线圈和集成电路组成，以产生驱动封装中的光检测元件所需的电压。 从而实现了可移动和安全的模块型光检测器。