公开(公告)号：US10961283B2

公开(公告)日：2021-03-30

申请号：US16312166

申请日：2017-06-27

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Kwong ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Aliaksandr Druz ,  Ulrich Baxa ,  Joseph Van Galen ,  Cheng Cheng ,  John Mascola ,  Yaroslav Tsybovsky ,  Yongping Yang ,  Barney Graham ,  Syed Mohammad Moin ,  Jeffrey Boyington

IPC分类号： C07K14/11 ,  A61K39/21 ,  C12N7/00 ,  C07K14/08 ,  C07K14/16 ,  C07K14/165 ,  C07K14/435 ,  A61K39/00

摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

公开(公告)号：US11878998B2

公开(公告)日：2024-01-23

申请号：US17524380

申请日：2021-11-11

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Kwong ,  Barney Graham ,  John Mascola ,  Li Ou ,  Aliaksandr Druz ,  Man Chen ,  Wing-Pui Kong ,  Ivelin Stefanov Georgiev ,  Emily Rundlet ,  Michael Gordon Joyce ,  Yaroslav Tsybovsky ,  Paul Thomas ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Joseph Van Galen ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Ulrich Baxa

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61P37/04 ,  A61P31/14 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61P31/14 ,  A61P37/04 ,  A61K39/00 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/50 ,  C07K2319/70 ,  C07K2319/735 ,  C12N2710/10343 ,  C12N2760/18522 ,  C12N2760/18523 ,  C12N2760/18534

摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

公开(公告)号：US11939356B2

公开(公告)日：2024-03-26

申请号：US17202231

申请日：2021-03-15

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Kwong ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Masaru Kanekiyo ,  Aliaksandr Druz ,  Ulrich Baxa ,  Joseph Van Galen ,  Cheng Cheng ,  John Mascola ,  Yaroslav Tsybovsky ,  Yongping Yang ,  Barney Graham ,  Syed Mohammad Moin ,  Jeffrey Boyington

IPC分类号： C07K14/11 ,  A61K39/21 ,  C07K14/08 ,  C07K14/16 ,  C07K14/165 ,  C07K14/435 ,  C12N7/00 ,  A61K39/00

CPC分类号： C07K14/11 ,  A61K39/21 ,  C07K14/082 ,  C07K14/162 ,  C07K14/165 ,  C07K14/43563 ,  C12N7/00 ,  A61K2039/55555 ,  C07K2319/735 ,  C12N2740/16134 ,  C12N2760/16134 ,  C12N2770/20034

摘要： Disclosed are recombinant insect ferritin nanoparticles that can be used to display two different trimeric antigens at an equal ratio. Also disclosed are nucleic acids encoding the recombinant insect ferritin nanoparticles and methods of producing the recombinant insect ferritin nanoparticles. Methods for eliciting an immune response in a subject are also provided.

公开(公告)号：US11174292B2

公开(公告)日：2021-11-16

申请号：US16089993

申请日：2017-03-29

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Kwong ,  Barney Graham ,  John Mascola ,  Li Ou ,  Aliaksandr Druz ,  Man Chen ,  Wing-Pui Kong ,  Ivelin Stefanov Georgiev ,  Emily Rundlet ,  Michael Gordon Joyce ,  Yaroslav Tsybovsky ,  Paul Thomas ,  Marie Pancera ,  Mallika Sastry ,  Cinque Soto ,  Joseph Van Galen ,  Guillaume Stewart-Jones ,  Yongping Yang ,  Baoshan Zhang ,  Ulrich Baxa

IPC分类号： C07K14/005 ,  A61K39/12 ,  A61P37/04 ,  A61P31/14 ,  A61K39/00

摘要： Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.

公开(公告)号：US10400015B2

公开(公告)日：2019-09-03

申请号：US15508885

申请日：2015-09-04

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Peter Kwong ,  Marie Pancera ,  Tongqing Zhou ,  Ivelin Georgiev ,  Michael Gordon Joyce ,  Priyamvada Acharya ,  Jason Gorman ,  Yongping Yang ,  Aliaksandr Druz ,  Guillaume Stewart-Jones ,  Rita Chen ,  Gwo-Yu Chuang ,  Ulrich Baxa ,  John Mascola ,  Rebecca Lynch ,  Baoshan Zhang ,  Cheng Cheng

IPC分类号： C07K14/435 ,  A61K39/21 ,  G01N33/569 ,  A61K39/12 ,  C07K14/005 ,  C07K16/10 ,  A61K39/00

摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.