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    Extracellular Serine Protease
    1.
    发明申请
    Extracellular Serine Protease 有权
    细胞外丝氨酸蛋白酶

    公开(公告)号：US20120264123A1

    公开(公告)日：2012-10-18

    申请号：US13486011

    申请日：2012-06-01

    申请人： Timothy J. O'Brien ,  Lowell J. Underwood ,  John Beard ,  Kazushi Shigemasa

    发明人： Timothy J. O'Brien ,  Lowell J. Underwood ,  John Beard ,  Kazushi Shigemasa

    IPC分类号： C07K16/18 ,  C12Q1/68

    CPC分类号： C07K14/4748 ,  C12N9/6424 ,  G01N33/57407 ,  G01N2333/96433 ,  G01N2500/00

    摘要： The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.

    摘要翻译： 本发明提供编码在卵巢，乳腺和结肠癌样品中过表达的称为肿瘤抗原衍生基因-14（TADG-14）的新型细胞外丝氨酸蛋白酶的DNA。 还提供了能够表达本发明的DNA的载体和宿主细胞以及本发明的DNA和蛋白质的用途。 还提供了TADG-14蛋白质变体，其具有检测和靶向卵巢癌的潜在作用。

    Monitor Transducer System and Manufacturing Method Thereof
    9.
    发明申请
    Monitor Transducer System and Manufacturing Method Thereof 审中-公开
    监测传感器系统及其制造方法

    公开(公告)号：US20070230734A1

    公开(公告)日：2007-10-04

    申请号：US11696421

    申请日：2007-04-04

    申请人： John Beard

    发明人： John Beard

    IPC分类号： H04R9/08 ,  H04R11/04 ,  H04R21/02 ,  H04R3/00

    CPC分类号： H04R1/04 ,  H04R19/04

    摘要： A microphone assembly comprises a housing having a top housing and a bottom housing fixed attached together, defining a volume. The microphone assembly further comprises a motor assembly and a circuit assembly disposed within the housing. The motor assembly includes a backplate and a diaphragm. The motor assembly further comprises a first end and a second end spaced apart by a central portion wherein a portion of the first and second ends fixedly attached to the inner surface of the top housing or the bottom housing. The circuit assembly includes a connecting lead for making contact with the diaphragm or a backplate. The circuit assembly is arranged in series with the motor assembly, but not stacked over or under the motor assembly.

    摘要翻译： 麦克风组件包括壳体，壳体具有固定在一起的顶部壳体和底部壳体，其限定了体积。 麦克风组件还包括马达组件和设置在壳体内的电路组件。 马达组件包括背板和隔膜。 电动机组件还包括第一端和与中心部分间隔的第二端，其中第一和第二端的一部分固定地附接到顶部壳体或底部壳体的内表面。 电路组件包括用于与隔膜或背板接触的连接引线。 电路组件与电机组件串联布置，但不堆叠在电机组件上或下。

    CA125 gene and its use for diagnostic and therapeutic interventions
    10.
    发明授权
    CA125 gene and its use for diagnostic and therapeutic interventions 有权
    CA125基因及其在诊断和治疗干预中的应用

    公开(公告)号：US08124728B2

    公开(公告)日：2012-02-28

    申请号：US10475117

    申请日：2003-10-17

    申请人： Timothy O'Brien ,  John Beard ,  Lowell Underwood

    发明人： Timothy O'Brien ,  John Beard ,  Lowell Underwood

    IPC分类号： C07K14/00 ,  C07K14/435

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C12Q1/6886 ,  C12Q2600/158

    摘要： The CA125 gene has been cloned. The CA125 molecule comprises three major domains: an extracellular amino terminal domain; a large multiple repeat domain; and a carboxy terminal domain which includes a transmembrane anchor with a short cytoplasmic domain. Additionally, an amino terminal extension is present. The molecular structure is dominated by a repeat domain comprising more than sixty 156-amino-acid repeat units The repeat units encompass an interactive disulfide bridged C-enclosure and the site of OC125 and M11 binding. The CA125 molecule is anchored at its carboxy terminal through a transmembrane domain and a short cytoplasmic tail. The structure has potential for use as a new gold standard for detecting the CA125 antigen, and can provide a basis for the development of a vaccine useful for the treatment of ovarian cancer and other carcinomas where CA125 is elevated.

    摘要翻译： 已经克隆了CA125基因。 CA125分子包含三个主要的结构域：细胞外氨基末端结构域; 一个大的多重重复域; 和包含具有短细胞质结构域的跨膜锚的羧基末端结构域。 此外，存在氨基末端延伸。 分子结构由包含多于六十六个156个氨基酸重复单元的重复结构域所支配。重复单元包含交互式二硫键桥接的C-封闭物和OC125和M11结合位点。 CA125分子在其羧基末端通过跨膜结构域和短的胞质尾部锚定。 该结构有可能用作检测CA125抗原的新金标准，可为开发可用于治疗CA125升高的卵巢癌和其他癌症的疫苗提供依据。