摘要:
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
摘要:
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
摘要:
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
摘要:
The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.
摘要:
Apparatus for detecting irregularities in the diameter of a filament has a small light source placed at the focus of an objective lens system. A horizontal slot constitutes a diaphragm for the objective lens system. A first optical system forms an image of the slot in a plane in which the filament runs past. Detectors detect the beam intercepted by the filament. An optical splitting system (P1) is interposed in the path of the beam (A), downstream of the slot (3) and upstream of the filament (5). The system is designed to form two sharp images (3', 3") of the slot (3) in a plane (4). The detectors are two oppositely-connected detectors (D1, D2) each receiving a respective beam (C, C') intercepted by the filament (5).
摘要:
An automatic sheet metal cutting machine has a continuous supply of metal strips in adjustable lengths, at will. A reciprocating cutter cuts laminations from the metal strip and a receiver receives the laminations. The receiver includes a swiveling plate movable through an angle .alpha. at will about a pin perpendicular to the direction motion of the laminations. The receiver is lowered and moved downstream relative to the direction of motion of the laminations received thereby.
摘要:
A rotary sealing device for connecting a fixed gas supply pipe to a tube rotating about its axis. It comprises a first rotary member for receiving the fixed pipe, a second rotary member for receiving and sealing the rotary pipe and fixed to the first member, and a filter placed in a chamber made in the aforementioned members and forming an obstacle to the gas flow and consequently to an overpressure of said gas, opposing the entry into the said chamber of gas coming from outside the device.
摘要:
This induction winding includes a magnetic core formed by a vertical stack of iron disks separated by air gaps. The disks (8) include a plurality of sector-shaped portions (1) each of which is constituted by a succession of magnetic laminations (6), a first part (12,13) of these laminations are all of identical length and a second part (14) are of regularly decreasing length from one lamination to the next. The direction (F.sub.1) in which the laminations are rolled in the mill is perpendicular to the axis (7) of the winding. The increased magnetic loss that this causes is compensated by the improved filling coefficient that can then be readily obtained.
摘要:
The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method comprises (a) determining a first concentration of melanoma inhibitory activity protein (MIA) in a first biological sample taken from the mammalian subject before treatment with the melanoma inhibitory agent; (b) determining a second concentration of MIA in a second biological sample from the mammalian subject taken after treatment with the melanoma inhibitory agent; and (c) comparing the first and second concentrations of MIA, wherein a decrease in the second concentration of MIA measured in the second biological sample as compared to the first concentration of MIA measured in the first biological sample indicates a positive response to the treatment with the melanoma inhibitory agent.
摘要:
The present invention provides novel biomarkers for cancer: the phosphorylation of ZC1 and/or ZC3 kinase substrates, particularly p120 catenin and Abi-1. Accordingly, the invention provides methods of determining whether a compound modulates ZC1 or ZC3 kinase activity, methods of determining whether a mammal is responding to a compound that modulates ZC1 or ZC3 kinase activity, and methods of predicting whether a mammal will respond therapeutically to a method of treating cancer by administering a modulator of ZC1 or ZC3 kinase.