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公开(公告)号：US20090062824A1
公开(公告)日：2009-03-05
申请号：US12229343
申请日：2008-08-22
IPC分类号： A61B17/122
CPC分类号： A61F5/005 , A61B2017/00818 , A61B2017/00876 , A61F2/0018 , A61F2/0036 , A61F5/0066 , A61F2210/009
摘要： A structure that can be used as a gastric band (and that may also have other uses as an implant elsewhere in a patient) includes a plurality of magnetic elements in a serial array that can be implanted so that the array extends in a circumferential direction around the patient's stomach (or other body tissue structure in the patient). Circumferentially adjacent magnetic elements magnetically attract one another to apply radial pressure to the tissue structure encompassed by the array, but those elements can also move apart in response to sufficient outward pressure from the encompassed tissue structure and/or the contents of (e.g., food in) that tissue structure. When used as a gastric band, the device can provide resistance to excessive food intake, which can help promote weight loss.
摘要翻译： 可以用作胃带（并且还可以作为其他用途在医院其他地方的其他用途）的结构包括可以植入的串联阵列中的多个磁性元件，使得阵列沿圆周方向延伸 患者的胃（或患者的其他身体组织结构）。 周向相邻的磁性元件相互磁吸引，以向阵列所包围的组织结构施加径向压力，但是这些元件也可以响应于来自包围的组织结构的足够的向外压力和/或（例如， ）组织结构。 当用作胃带时，该装置可以提供抵抗过量食物摄取，这可以帮助促进减肥。
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公开(公告)号：US08715157B2
公开(公告)日：2014-05-06
申请号：US12229343
申请日：2008-08-22
CPC分类号： A61F5/005 , A61B2017/00818 , A61B2017/00876 , A61F2/0018 , A61F2/0036 , A61F5/0066 , A61F2210/009
摘要： A structure that can be used as a gastric band (and that may also have other uses as an implant elsewhere in a patient) includes a plurality of magnetic elements in a serial array that can be implanted so that the array extends in a circumferential direction around the patient's stomach (or other body tissue structure in the patient). Circumferentially adjacent magnetic elements magnetically attract one another to apply radial pressure to the tissue structure encompassed by the array, but those elements can also move apart in response to sufficient outward pressure from the encompassed tissue structure and/or the contents of (e.g., food in) that tissue structure. When used as a gastric band, the device can provide resistance to excessive food intake, which can help promote weight loss.
摘要翻译： 可以用作胃带（并且还可以作为其他用途在医院其他地方的其他用途）的结构包括可以植入的串联阵列中的多个磁性元件，使得阵列沿圆周方向延伸 患者的胃（或患者的其他身体组织结构）。 周向相邻的磁性元件相互磁吸引，以向阵列所包围的组织结构施加径向压力，但是这些元件也可以响应于来自包围的组织结构的足够的向外压力和/或（例如， ）组织结构。 当用作胃带时，该装置可以提供抵抗过量食物摄取，这可以帮助促进减肥。
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公开(公告)号：US6120522A
公开(公告)日：2000-09-19
申请号：US141209
申请日：1998-08-27
CPC分类号： A61F2/95 , A61F2/0095 , A61F2/91 , A61F2002/011 , A61F2002/3008 , A61F2002/30448 , A61F2002/9665 , A61F2220/005 , A61F2250/0098
摘要： The present invention provides a self-expanding stent delivery system comprising a catheter, a self-expanding stent having a plurality of interconnected expansion cells therein and concentrically arranged around the catheter near the distal end of the catheter, a retractable sheath for covering the stent constructed and arranged for retraction to release the stent to self-expand, and a stent holder abutting the stent for holding the stent in place until the retractable sheath is fully retracted. During retraction of the retractable cover, the stent holder prevents the stent from substantially moving longitudinally until the retractable sheath has been completely removed from the stent.
摘要翻译： 本发明提供了一种自扩张支架输送系统，其包括导管，其中具有多个相互连接的膨胀细胞的自扩张支架，并且在导管的远端附近围绕导管同心布置，用于覆盖支架的伸缩护套 并且布置成用于缩回以释放支架以自扩张，并且支架支架邻接支架以将支架保持在适当位置，直到可伸缩护套完全缩回。 在缩回可缩回的盖子期间，支架支架防止支架基本上纵向移动，直到伸缩护套已从支架完全移除。
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公开(公告)号：US20140235554A1
公开(公告)日：2014-08-21
申请号：US14179034
申请日：2014-02-12
申请人： Brian Lawrence , Jon St. Germain
发明人： Brian Lawrence , Jon St. Germain
IPC分类号： A61K38/17 , A61K47/26 , A61K45/06 , C07K14/435 , A61K31/728
CPC分类号： A61K38/1767 , A61K9/0048 , A61K31/728 , A61K45/06 , A61K47/26 , A61K47/36 , C07K14/43586
摘要： An ophthalmic composition is described for the treatment of dry eye syndrome in a human or mammal. The composition comprises an aqueous solution including an effective amount of silk protein. The aqueous solution comprises from about 0.01% by weight to about 30% by weight of the silk protein. In one embodiment, the silk protein may be fibroin. A method of treating an eye having an ocular surface is also described. The method comprises providing an ophthalmic composition comprising an aqueous solution including an effective amount of silk protein, and administering the ophthalmic composition topically to the ocular surface.
摘要翻译： 描述了用于治疗人或哺乳动物的干眼综合征的眼用组合物。 组合物包含含有有效量的丝蛋白的水溶液。 该水溶液占丝蛋白质的约0.01重量％至约30重量％。 在一个实施方案中，丝蛋白可以是丝心蛋白。 还描述了一种治疗具有眼表面的眼睛的方法。 该方法包括提供一种眼用组合物，其包含含有有效量的丝蛋白的水溶液，并将眼用组合物局部施用于眼表面。
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公开(公告)号：US08652192B2
公开(公告)日：2014-02-18
申请号：US11395196
申请日：2006-03-31
申请人： Jon St. Germain , Daniel O. Adams
发明人： Jon St. Germain , Daniel O. Adams
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/852 , A61F2/915 , A61F2/95 , A61F2002/91541 , A61F2002/91558 , A61F2002/91591 , A61F2002/9665 , A61F2230/0054 , A61F2250/0063 , A61F2250/0071
摘要： The present invention is a vascular stent comprising a cylindrical wall radially expandable from a compressed state to an expanded state and including a plurality of cells. At least one cell includes a first primary member having a first restrainer member and a second primary member having a second restrainer member. When the cylindrical wall is in the expanded state, the first and second primary members are located a greater distance from each other than when the cylindrical wall is in the compressed state. The first and second restrainer members join to maintain the cylindrical wall in the compressed state. An expansion force applied to the cylindrical wall causes the first and second restrainer members to separate, thereby freeing the cylindrical wall to expand from the compressed state to the expanded state.
摘要翻译： 本发明是一种血管支架，其包括从压缩状态向膨胀状态径向扩张并包括多个细胞的圆柱形壁。 至少一个电池包括具有第一限制器构件的第一主构件和具有第二限制构件的第二主构件。 当圆柱形壁处于膨胀状态时，与圆柱形壁处于压缩状态相比，第一和第二主要构件彼此相距较大。 第一和第二限制件连接以将圆筒壁保持在压缩状态。 施加到圆筒壁上的膨胀力使得第一和第二限制构件分离，从而使圆柱形壁从压缩状态膨胀到膨胀状态。
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公开(公告)号：US08273054B2
公开(公告)日：2012-09-25
申请号：US11848461
申请日：2007-08-31
IPC分类号： A61M25/09
CPC分类号： A61M25/0136 , A61M25/0041 , A61M25/005 , A61M25/0053 , A61M25/0054
摘要： A system for arterial access for delivery of treatment devices is provided. In one embodiment, the system comprises a guidewire and a catheter. The catheter comprises a handle and a shaft. The shaft may be a steerable/deflectable tip shaft with a lumen adapted to allow passage of the guidewire at least partially there through. A passive sheath may also be provided to be delivered over the shaft. The handle controls the steerable/deflectable tip shaft and may be used to deflect the distal tip of the shaft.
摘要翻译： 提供了用于输送治疗装置的用于动脉通路的系统。 在一个实施例中，系统包括导丝和导管。 导管包括手柄和轴。 轴可以是可转向/可偏转的尖端轴，其具有适于允许导丝至少部分地通过导管的内腔。 也可以设置被动护套以在轴上传送。 手柄控制可转向/可偏转的尖端轴，并可用于偏转轴的远端。
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7.发明申请Partial aortic occlusion devices and methods for cerebral perfusion augmentation 审中-公开局部主动脉闭塞装置和脑灌注增强的方法公开(公告)号：US20070135793A1
公开(公告)日：2007-06-14
申请号：US11655811
申请日：2007-01-18
申请人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
发明人： Denise Barbut , Peter Keith , Steven Berhow , Jon St. Germain
IPC分类号： A61M31/00
CPC分类号： A61B17/12045 , A61B5/0215 , A61B5/4076 , A61B6/481 , A61B17/12036 , A61B17/12109 , A61B17/12136 , A61B17/12145 , A61B17/1219 , A61B2017/22054 , A61B2090/3966 , A61F7/12 , A61F2002/068 , A61F2007/126 , A61M25/00 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/0069 , A61M25/0074 , A61M25/008 , A61M25/0082 , A61M25/0147 , A61M25/0662 , A61M25/1011 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2025/0081 , A61M2025/1052 , A61M2210/127 , A61M2230/005 , A61M2230/30
摘要： Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
摘要翻译： 为全脑或局灶性脑缺血患者提供局部主动脉阻塞用于脑灌注增强的方法。 或者，所述方法可用于部分阻塞主动脉血流以调节脊髓以在腹主动脉瘤修复之前分泌神经保护剂。 容器的部分阻塞可以通过包括细长导管和远侧安装的可扩张构件的装置来实现。 可膨胀构件可以包括一个或两个气囊。 诸如血管成形术，支架或粥样斑块切除术导管的其它医疗装置可以在可扩张构件的远端插入以提供治疗干预。
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公开(公告)号：US11033375B2
公开(公告)日：2021-06-15
申请号：US15883044
申请日：2018-01-29
申请人： Jon St. Germain
发明人： Jon St. Germain
摘要： Sphincter reinforcement devices are described. Sphincter reinforcement devices may be configured to be placed at least partially around a bodily passage at or near a sphincter. In one embodiment, a sphincter reinforcement device may comprise a ring including a tubular structure. The ring may be expandable. The tubular structure may be hollow. The tubular structure may have a first end and a second end. The first end may be configured to be coupled to the second end. The tubular structure may include a braided material.
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公开(公告)号：US20080154190A1
公开(公告)日：2008-06-26
申请号：US11848461
申请日：2007-08-31
IPC分类号： A61M25/092 , A61M25/09 , A61M25/00
CPC分类号： A61M25/0136 , A61M25/0041 , A61M25/005 , A61M25/0053 , A61M25/0054
摘要： A system for arterial access for delivery of treatment devices is provided. In one embodiment, the system comprises a guidewire and a catheter. The catheter comprises a handle and a shaft. The shaft may be a steerable/deflectable tip shaft with a lumen adapted to allow passage of the guidewire at least partially there through. A passive sheath may also be provided to be delivered over the shaft. The handle controls the steerable/deflectable tip shaft and may be used to deflect the distal tip of the shaft.
摘要翻译： 提供了用于输送治疗装置的用于动脉通路的系统。 在一个实施例中，系统包括导丝和导管。 导管包括手柄和轴。 轴可以是可转向/可偏转的尖端轴，其具有适于允许导丝至少部分地通过导管的内腔。 也可以设置被动护套以在轴上传送。 手柄控制可转向/可偏转的尖端轴，并可用于偏转轴的远端。
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公开(公告)号：US20060100691A1
公开(公告)日：2006-05-11
申请号：US11318196
申请日：2005-12-23
申请人： Jon St. Germain
发明人： Jon St. Germain
IPC分类号： A61F2/06
CPC分类号： A61F2/88 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/30014 , A61F2002/30093 , A61F2002/30199 , A61F2002/30322 , A61F2002/30324 , A61F2002/30327 , A61F2002/821 , A61F2002/91533 , A61F2002/91558 , A61F2210/0019 , A61F2230/0063 , A61F2250/0018 , A61F2250/0026 , A61F2250/0036 , A61F2250/0039
摘要： A stent having varying outward radial force along its length. In use, the stent can provide greater force in vessel regions requiring greater force and less force in regions requiring less. In particular, more force is provided in the narrowed, center of a stenosis, while not applying too much force to the adjoining healthy tissue area. Greater stent expansion is provided in wider vessel geometries and less stent expansion in narrower regions. Varying force is achieved varying the number of elements, the density of elements, and the thickness of the elements.
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