-
1.发明申请公开(公告)号：US20200333301A1
公开(公告)日：2020-10-22
申请号：US16917178
申请日：2020-06-30
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph D. Michienzi , Geoff Gerhardt , James P. Murphy
Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
-
公开(公告)号：US20180161770A1
公开(公告)日：2018-06-14
申请号：US15892863
申请日：2018-02-09
Applicant: Waters Technologies Corporation
Inventor： Pamela J. Longenbach , Moon Chul Jung , Frank J. Marszalkowski, JR. , Geoff Gerhardt
IPC: B01L3/00
CPC classification number: B01L3/502 , B01L3/5453 , B01L2300/021 , B01L2300/044 , B01L2300/0681 , B01L2300/0832 , B01L2400/0478 , G01N1/38 , G01N2001/288
Abstract: Provided are devices and methods for sample collection and processing. A tubular body has a chamber closed at a first end by a thin penetrable barrier and open at a second end opposite the first end. The tubular body further includes a partition that divides the chamber into two adjacent compartments, wherein a first compartment of the two adjacent compartments has the partition facing opposite the open end of the chamber and a second compartment of the two adjacent compartments has the partition facing opposite the closed end of the chamber. The partition has one or more holes to allow passage of fluid from the first compartment into the second compartment. A tracking identification may be permanently affixed to the first end of the tubular body.
-
公开(公告)号：US11733216B2
公开(公告)日：2023-08-22
申请号：US16917178
申请日：2020-06-30
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph D. Michienzi , Geoff Gerhardt , James P. Murphy
CPC classification number: G01N30/32 , B01D15/08 , B01D15/161 , B01D15/163 , B01D15/40 , G01N30/8658 , G01N2030/025 , G01N2030/324
Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
-
4.发明授权公开(公告)号：US10071374B2
公开(公告)日：2018-09-11
申请号：US14904135
申请日：2014-08-04
Applicant: Waters Technologies Corporation
Inventor： Joseph D. Michienzi , James P. Murphy , Michael O. Fogwill , Keith Fadgen , Geoff Gerhardt , Gary W. Bertone
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/50273 , B01L3/502761 , B01L7/54 , B01L2200/0652 , B01L2200/12 , B01L2300/0883 , B01L2300/1805 , B01L2300/1811 , B01L2300/1894
Abstract: A microfluidic device, for use in separation systems, includes a substrate having a fluidic channel. One or more heaters made of a thick film material are integrated with the substrate and in thermal communication with the fluidic channel of the substrate. The one or more heaters produce a thermal gradient within the fluidic channel in response to a current flowing through the one or more heaters. A plurality of electrically conductive taps can be in electrically conductive contact with the one or more heaters. The plurality of electrically conductive taps provides an electrically conductive path to the one or more heaters by which an electrical supply can produce the current flowing through the one or more heaters. Alternatively, the thick film material can be ferromagnetic, and the electrical supply can use induction to cause the current to flow through the one or more heaters.
-
公开(公告)号：US09719971B2
公开(公告)日：2017-08-01
申请号：US14483389
申请日：2014-09-11
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph D. Michienzi , James P. Murphy , Geoff Gerhardt
CPC classification number: G01N30/68 , G01N30/6095
Abstract: The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.
-
Patent Agency Ranking
6.发明申请MATCHING THERMALLY MODULATED VARIABLE RESTRICTORS TO CHROMATOGRAPHY SEPARATION COLUMNS 审中-公开将热调节变量限制器与色谱分离柱相匹配公开(公告)号：US20160018367A1
公开(公告)日：2016-01-21
申请号：US14773786
申请日：2014-01-31
Applicant: WATERS TECHNOLOGIES CORPORATION
Inventor： Michael O. Fogwill , Joseph D. Michienzi , Geoff Gerhardt , James P. Murphy
CPC classification number: G01N30/32 , B01D15/08 , B01D15/161 , B01D15/163 , B01D15/40 , G01N30/8658 , G01N2030/025 , G01N2030/324
Abstract: Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package.
Abstract translation: 色谱系统中使用的热调节变量限制器可以独立控制通过色谱柱的可压缩流动相的系统压力和线速度。 用于配置独立控制可压缩流动相的系统压力和质量流量的色谱系统的方法包括确定用于色谱系统的色谱分离柱的类型，将热调节的可变限制器与色谱分离的类型相匹配 色谱柱在色谱系统运行期间一起使用，并将色谱柱与其匹配的热调节变量限制器捆绑在一起，作为单个包装进行分配。
-
公开(公告)号：US11105778B2
公开(公告)日：2021-08-31
申请号：US16098280
申请日：2017-05-04
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Richard W. Andrews , Peyton C. Beals , Thomas McDonald , Keith Fadgen , Jordan Kornfeld , Geoff Gerhardt , Sylvain Cormier
Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.
-
公开(公告)号：US20190170706A1
公开(公告)日：2019-06-06
申请号：US16098280
申请日：2017-05-04
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Richard W. Andrews , Peyton C. Beals , Thomas McDonald , Keith Fadgen , Jordan Kornfeld , Geoff Gerhardt , Sylvain Cormier
Abstract: A method for injecting a diluted sample in a chromatography system includes merging a flow of a sample and a flow of a diluent to form a flow of a diluted sample. A dilution ratio of the diluted sample equals a sum of the volumetric flow rates of the sample and the diluent divided by the volumetric flow rate of the sample. The diluted sample is stored in a holding element before injection into a chromatographic system flow. Sample dilution occurs under low pressure relative to the chromatographic flow thereby allowing lower pressure sample and diluent syringes to be used. Other benefits include reduced compressibility and a reduction in leaks due to the lower pressure operation. The method avoids problems associated with manual techniques which can introduce errors due, for example, to loss of sample, sample precipitation and adsorption of sample to vials.
-
公开(公告)号：US20150078962A1
公开(公告)日：2015-03-19
申请号：US14483389
申请日：2014-09-11
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph D. Michienzi , James P. Murphy , Geoff Gerhardt
IPC: G01N30/68
CPC classification number: G01N30/68 , G01N30/6095
Abstract: The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.
Abstract translation: 本公开内容涉及用于小规模分离的微流体火焰离子化检测器，例如微流体气相色谱法和基于微流体二氧化碳的流体色谱法。 在一些布置中，微流控逆流火焰离子化检测器采用非平行布置来将燃烧气体引入燃烧室。 在其他布置中，检测器壳体构造成使用电隔离配件将至少一个检测器电极并入外壳内。
-
公开(公告)号：US10852279B2
公开(公告)日：2020-12-01
申请号：US16092264
申请日：2017-04-19
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph D. Michienzi , Geoff Gerhardt
Abstract: A method for detecting an analyte in a chromatography system includes performing a separation using a mobile phase that includes an organic component. The separation is performed with a primary separation module such as a chromatographic column. A first effluent, from the primary separation module, is modulated so that a fluidic plug containing an amount of the organic component and an analyte is provided to a secondary separation module where a secondary separation is performed. A second effluent, from the secondary separation module, includes temporally-resolved organic component and analyte peaks due to selective retention of the analyte. The second effluent is provided to a flame-based detector which is disabled when the organic modifier peak is received and enabled at least during the time when the analyte peak is received. Thus the analyte can be detected without interference from any response of the detector to the organic component peak.
-
-
-
-
-
-
-
-
-
Search Results
12
records
(took 0.015 seconds)
