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    PERFUSION BIOREACTOR AND RELATED METHODS OF USE
    2.
    发明公开
    PERFUSION BIOREACTOR AND RELATED METHODS OF USE 审中-公开

    公开(公告)号：US20240218313A1

    公开(公告)日：2024-07-04

    申请号：US18609573

    申请日：2024-03-19

    申请人： Regeneron Pharmaceuticals, Inc.

    发明人： Matthew ANGELINI ,  Ashley WITMER ,  Anthony DEBIASE

    IPC分类号： C12M1/34 ,  C12M1/00

    CPC分类号： C12M41/46 ,  C12M21/14 ,  C12M29/04 ,  C12M29/10 ,  C12M41/14 ,  C12M41/26 ,  C12M41/30 ,  C12M41/32 ,  C12M41/38 ,  C12M43/00

    摘要： A method of controlling a bioreactor system includes providing a cell culture in a bioreactor, wherein conditions in the bioreactor enable the cell culture to produce a protein of interest (POI), measuring process parameters (PPs) of the culture within the bioreactor by RAMAN, wherein the process parameters are selected from the group consisting of nutrient concentration, viable cell concentration, and protein attributes, measuring a predetermined weight of the bioreactor with the cell culture, removing cell-free spent media from the cell culture using a first output conduit at a first specified rate, removing cells from the cell culture using a second output conduit at a second specified rate, and introducing one or both of fresh media or nutrients into the cell culture using an input conduit at a third specified rate.

    Methods and Systems for Optimizing Culture Conditions in a Culture Process
    4.
    发明公开
    Methods and Systems for Optimizing Culture Conditions in a Culture Process 审中-公开

    公开(公告)号：US20240209306A1

    公开(公告)日：2024-06-27

    申请号：US18287287

    申请日：2022-12-21

    申请人： POW Genetic Solutions, Inc.

    发明人： Shannon HALL ,  Ouwei WANG ,  Brian LEE ,  Charles EMRICH

    IPC分类号： C12M1/36 ,  C12M1/00 ,  C12M1/34 ,  C12N1/20

    CPC分类号： C12M41/48 ,  C12M27/20 ,  C12M29/06 ,  C12M41/12 ,  C12M41/26 ,  C12M41/32 ,  C12M41/34 ,  C12N1/20

    摘要： Methods and systems for iteratively improving culture condition for at least one culture output in a culture process. The methods comprise: a) providing a continuous culture of cells in a bioreactor, wherein the cells are cultured under culture conditions that comprise a set of culture parameters. and wherein the culture of cells produces at least one culture output at a first measure: b) while maintaining the cells in continuous culture, iteratively testing different culture conditions by: (i) selecting a new culture condition comprising a new set of culture parameters predicted to improve the measure of the culture output: (ii) perturbing the cells with the new culture conditions: and (iii) determining a new measure of the culture output: wherein testing is iterated to produce a plurality of improvements in the measure of culture output. The iterative process can be performed by an automated artificial intelligence.

    CELL CULTURE DEVICE, SYSTEM AND METHODS OF USE THEREOF
    6.
    发明公开
    CELL CULTURE DEVICE, SYSTEM AND METHODS OF USE THEREOF 审中-公开

    公开(公告)号：US20240182844A1

    公开(公告)日：2024-06-06

    申请号：US18545965

    申请日：2023-12-19

    申请人： Oribiotech Ltd.

    发明人： Christopher Mason ,  Farlan Veraitch

    IPC分类号： C12M1/34 ,  A61M5/148 ,  A61M5/28 ,  C12M1/00

    CPC分类号： C12M41/44 ,  A61M5/148 ,  A61M5/282 ,  C12M23/26 ,  C12M41/32

    摘要： The present invention provides a method for culturing cells in a cell culture container having a base section, a top section arranged in parallel with the top section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the container is compressible with respect to the top and bottom section, and in which the top section of the container has an optionally sealable inlet, in which the container is composed of a flexible material, comprising culturing cells in a culture medium in the cell culture container. Also provided is a cell culture container having a base section, a top section arranged in parallel with the top section and a wall element arranged between the top section and the base section and defining an internal lumen of the container, in which the wall element of the container is compressible with respect to the top and bottom section, and in which the top section of the container has an optionally sealable inlet, in which the wall element of the container is composed of a flexible material.

    MICRO-ORGAN SPECIFICITY MAINTENANCE SYSTEM
    9.
    发明公开
    MICRO-ORGAN SPECIFICITY MAINTENANCE SYSTEM 审中-公开

    公开(公告)号：US20240110135A1

    公开(公告)日：2024-04-04

    申请号：US18084588

    申请日：2022-12-20

    申请人： Yulin CAO ,  Tangyi Holding (Shenzhen) Co., Ltd.

    发明人： Yulin CAO

    IPC分类号： C12M3/00 ,  A01N1/02 ,  C12M1/00 ,  C12M1/34 ,  C12M1/36 ,  G01N33/50

    CPC分类号： C12M21/08 ,  A01N1/0247 ,  C12M23/44 ,  C12M29/10 ,  C12M41/32 ,  C12M41/48 ,  G01N33/5088

    摘要： A micro-organ specificity maintenance system includes a micro-organ specificity parallel reactor module for storing and culturing vascularized micro-organs; a feeding module for feeding culture solutions to the micro-organ specificity parallel reactor module; an injection module for injecting medical solutions containing traditional Chinese medicine micromolecules into the micro-organ specificity parallel reactor module; a micro-organ circulation coupling module for transmitting venous flow and arterial flow to the micro-organ specificity parallel reactor module; and a micro-organ neural coupling module for transmitting neural network signals to the micro-organ specificity parallel reactor module. The micro-organ specificity maintenance system provided in the disclosure has the advantage that an extracorporeal circulation system and internal vascular systems of complex organs are organically integrated and connected.