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1.发明申请Hyperbaric Device and Methods for Producing Inactivated Vaccines and for Refolding/Solubilizing Recombinant Proteins 有权用于产生灭活疫苗和重折叠/重组蛋白质的高压装置和方法公开(公告)号：US20140065187A1
公开(公告)日：2014-03-06
申请号：US14014434
申请日：2013-08-30
Applicant: Nicolas Pierre Yves Carboulec , Gildas Merian , Rene Labatut , Lionel Gerentes
Inventor： Nicolas Pierre Yves Carboulec , Gildas Merian , Rene Labatut , Lionel Gerentes
CPC classification number: C07K14/44 , A23L3/0155 , A61K39/008 , A61K39/0225 , A61K39/0241 , A61K39/099 , A61K2039/552 , A61L2/0011 , C07K14/245 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12N5/0031 , C12N9/1007 , C12N9/50 , C12N9/52 , C12P21/02 , C12Y201/01041 , C12Y304/22
Abstract: The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms, and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
Abstract translation: 本发明涉及用于灭活微生物和病毒的高压装置，同时保留其免疫原性并用于制备和产生可从原核生物或真核生物产生的包涵体的可溶性，分解，重折叠或活性免疫原性或治疗性蛋白质。 本发明包括用于灭活致病生物体的高压方法，以及使用灭活病原体生产疫苗组合物的方法。 高温灭活的微生物比化学灭活的微生物更安全，更具免疫原性。 类似地，与更重聚集的蛋白质相比，溶解的蛋白质具有优异的性质，包括减少的非特异性免疫反应。
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2.发明申请公开(公告)号：US20170081372A1
公开(公告)日：2017-03-23
申请号：US15017486
申请日：2016-02-05
Applicant: MERIAL INC.
Inventor： Laurent Bernard Fischer , Nicolas Pierre Yves Carboulec , Fabien Lux
IPC: C07K14/44 , C12N9/50 , A61K39/008 , C12N9/10
CPC classification number: C07K14/245 , A23L3/0155 , A61K39/008 , A61K39/0225 , A61K39/0241 , A61K39/099 , A61K2039/552 , A61L2/0011 , C07K14/44 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12N5/0031 , C12N9/1007 , C12N9/50 , C12N9/52 , C12P21/02 , C12Y201/01041 , C12Y304/22
Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
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3.发明申请EXPRESSION OF CHIMERIC KSAC PROTEIN AND METHOD OF PRODUCING SOLUBLE PROTEINS BY HIGH PRESSURE 有权CHIMERIC KSAC蛋白的表达及高压生产可溶性蛋白质的方法公开(公告)号：US20140072594A1
公开(公告)日：2014-03-13
申请号：US14014437
申请日：2013-08-30
Applicant: Laurent Bernard Fischer , Nicolas Pierre Yves Carboulec , Fabien Lux
Inventor： Laurent Bernard Fischer , Nicolas Pierre Yves Carboulec , Fabien Lux
IPC: C07K14/245 , C12N9/52 , C12N9/10
CPC classification number: C07K14/44 , A23L3/0155 , A61K39/008 , A61K39/0225 , A61K39/0241 , A61K39/099 , A61K2039/552 , A61L2/0011 , C07K14/245 , C07K2319/00 , C07K2319/35 , C07K2319/40 , C12N5/0031 , C12N9/1007 , C12N9/50 , C12N9/52 , C12P21/02 , C12Y201/01041 , C12Y304/22
Abstract: The present invention encompasses vaccines or compositions comprising the chimeric KSAC protein that possesses immunogenic and protective properties, and methods of use including administering to an animal the antigenic KSAC protein thereof to protect animals. The invention also encompasses methods for making and producing the soluble, disaggregated, refolded or active proteins from inclusion bodies produced from prokaryotes or eukaryotes.
Abstract translation: 本发明包括含有具有免疫原性和保护性质的嵌合KSAC蛋白质的疫苗或组合物，以及使用方法，包括向动物施用其抗原性KSAC蛋白质以保护动物。 本发明还包括从由原核生物或真核生物产生的包涵体制备和产生可溶，分解，重折叠或活性蛋白的方法。
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公开(公告)号：US20130210072A1
公开(公告)日：2013-08-15
申请号：US13548898
申请日：2012-07-13
Applicant: Christine Lang , Markus Veen
Inventor： Christine Lang , Markus Veen
IPC: C12P33/00
CPC classification number: C12P33/00 , C12N9/0004 , C12N9/0006 , C12N9/001 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y101/01088 , C12Y103/01072 , C12Y114/1307 , C12Y114/13132 , C12Y114/19 , C12Y201/01041 , C12Y503/03005
Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
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公开(公告)号：US12077795B2
公开(公告)日：2024-09-03
申请号：US16989843
申请日：2020-08-10
Inventor： Brian Callahan , Timothy Owen
CPC classification number: C12P21/00 , A61K47/55 , A61K47/554 , C07K1/1077 , C12N9/1029 , C12Y201/01041
Abstract: A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferase catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferase catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferase catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.
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Patent Agency Ranking
公开(公告)号：US20170204056A1
公开(公告)日：2017-07-20
申请号：US15515142
申请日：2015-10-08
Applicant: KYOWA HAKKO BIO CO., LTD.
Inventor： Tetsuro UJIHARA , Satoshi MITSUHASHI
IPC: C07C401/00 , B01J19/12 , C12N9/10 , C12P33/00 , C12P7/22
CPC classification number: C07C401/00 , B01J19/123 , B01J2219/12 , C12N9/1007 , C12N15/09 , C12P7/22 , C12P33/00 , C12Y201/01041
Abstract: According to the present invention, there can be provided a process for producing 7-dehydrocholesterol (7DHC), comprising culturing, in a medium, a 7DHC-producing Labyrinthulea microorganism in which sterol 24-C-methyltransferase activity is reduced or lost as compared to a parent strain, allowing 7DHC to be produced and accumulated in the culture, and collecting the 7DHC from the culture; and a process for producing vitamin D3, comprising irradiating, with ultraviolet light, 7-dehydrocholesterol produced by the production process.
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7.发明申请VACCINES COMPRISING LEISHMANIA POLYPEPTIDES FOR THE TREATMENT AND DIAGNOSIS OF LEISHMANIASIS 有权包含LEISHMANIA POLYPEPTIES用于治疗和诊断淋巴瘤的疫苗公开(公告)号：US20160186158A1
公开(公告)日：2016-06-30
申请号：US14780504
申请日：2014-03-28
Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
Inventor： Malcolm DUTHIE , Jeff GUDERIAN , Steven G. REED
IPC: C12N9/24 , G01N33/569 , C12N9/10 , A61K39/008
CPC classification number: C12N9/2497 , A61K39/008 , C12N9/1007 , C12Y201/01041 , C12Y302/02001 , G01N33/56905 , G01N2333/44 , G01N2469/20 , Y02A50/41
Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising Leishmania antigens as well as polynucleotides encoding such polypeptides.
Abstract translation: 公开了用于预防，治疗和检测利什曼病的组合物和方法。 组合物通常包含包含利什曼原虫抗原的多肽以及编码这种多肽的多核苷酸。
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8.发明授权Method for the production of 7-dehydrocholesterol and/or the biosynthetic intermediate or subsequent products thereof in transgenic organisms 有权在转基因生物体中生产7-脱氢胆固醇和/或生物合成中间体或其后续产物的方法公开(公告)号：US07608421B2
公开(公告)日：2009-10-27
申请号：US10503044
申请日：2003-01-22
Applicant: Christine Lang , Markus Veen
Inventor： Christine Lang , Markus Veen
CPC classification number: C12P33/00 , C12N9/0004 , C12N9/0006 , C12N9/001 , C12N9/0071 , C12N9/0073 , C12N9/1007 , C12N9/90 , C12N15/52 , C12N15/81 , C12Y101/01088 , C12Y103/01072 , C12Y114/1307 , C12Y114/13132 , C12Y114/19 , C12Y201/01041 , C12Y503/03005
Abstract: The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
Abstract translation: 本发明涉及通过培养生物体，特别是酵母来制备7-脱氢胆固醇和/或其生物合成中间体和/或其二次产物的方法。 此外，本发明涉及制备基因修饰生物体和所述转基因生物，特别是酵母本身所需的核酸构建体的制备。
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9.发明申请公开(公告)号：US20180112245A1
公开(公告)日：2018-04-26
申请号：US15782391
申请日：2017-10-12
Inventor： Brian Callahan , Timothy Owen
IPC: C12P21/00
CPC classification number: C12P21/00 , A61K47/55 , A61K47/554 , C07K1/1077 , C12N9/1029 , C12Y201/01041
Abstract: A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferse catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferse catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferse catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.
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10.发明授权公开(公告)号：US09909114B2
公开(公告)日：2018-03-06
申请号：US14780504
申请日：2014-03-28
Applicant: Infectious Disease Research Institute
Inventor： Malcolm Duthie , Jeff Guderian , Steven G. Reed
IPC: C12N9/24 , A61K39/008 , C12N9/10 , G01N33/569
CPC classification number: C12N9/2497 , A61K39/008 , C12N9/1007 , C12Y201/01041 , C12Y302/02001 , G01N33/56905 , G01N2333/44 , G01N2469/20 , Y02A50/41
Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising Leishmania antigens as well as polynucleotides encoding such polypeptides.
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