公开(公告)号：US12133883B2

公开(公告)日：2024-11-05

申请号：US17006589

申请日：2020-08-28

Applicant: Ascendis Pharma Endocrinology Division A/S

Inventor： Thomas Kurpiers ,  Harald Rau ,  Evelyn Exner ,  Steen Jensen ,  Grethe Nørskov Rasmussen ,  Torben Lessmann ,  Thomas Wegge ,  Alina Hermann ,  Nina Schubert ,  Anna Splanemann ,  Joachim Zettler

IPC: A61K38/27 ,  A61K9/08 ,  A61K47/12 ,  A61K47/20 ,  A61K47/26 ,  A61K47/60 ,  C08G65/334

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulation comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

公开(公告)号：US20220168448A1

公开(公告)日：2022-06-02

申请号：US17366846

申请日：2021-07-02

Applicant: École Polytechnique Fédérale de Lausanne (EPFL)

Inventor： Jeffrey A. HUBBELL ,  Conlin P. O'NEIL ,  Melody SWARTZ ,  Diana VELLUTO ,  André Van Der Vlies

IPC: A61K48/00 ,  A61K9/127 ,  A61K9/51 ,  C08G65/329 ,  C08G65/334 ,  C08G75/08 ,  C08L71/02 ,  C08G83/00 ,  A61K9/107 ,  A61K31/337 ,  A61K31/573 ,  A61K31/713 ,  A61K47/10 ,  A61K47/22 ,  A61K47/34 ,  C07K16/00 ,  C12N15/113 ,  C12N15/115

Abstract: An encoding/decoding apparatus and method using a low-density parity-check code (LDPC code) is disclosed. Basic column group information, serving as a set of information regarding positions of rows with weight 1, is extracted from a reference column in each column group of a predetermined parity-check matrix. Column group information transforms the positions of rows with weight 1 into positions whose lengths are within a required parity length. A parity-check matrix is generated according to the generated column group information. Data is enclosed or decoded based on the generated parity-check matrix.

公开(公告)号：US11305018B2

公开(公告)日：2022-04-19

申请号：US16801014

申请日：2020-02-25

Applicant: Vanderbilt University

Inventor： Eva M. Harth ,  Dain B. Beezer ,  GuangZhao Li ,  Benjamin R. Spears ,  David M. Stevens

IPC: A61K47/32 ,  A61K47/34 ,  C08G65/22 ,  A61K9/00 ,  A61K9/50 ,  C08G64/42 ,  C08G65/00 ,  C08G65/26 ,  C08G65/332 ,  C08G65/334 ,  C08G65/34

Abstract: Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20220079936A1

公开(公告)日：2022-03-17

申请号：US17535385

申请日：2021-11-24

Applicant: Nektar Therapeutics

Inventor： Xuan Zhao ,  Michael D. Bentley ,  Zhongxu Ren ,  Tacey X. Viegas

IPC: A61K31/4745 ,  C08G65/331 ,  C08G65/332 ,  C08G65/333 ,  C08G65/334 ,  A61K47/59 ,  A61K47/61 ,  A61K47/64 ,  A61K31/4709 ,  A61K47/60

Abstract: Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

公开(公告)号：US20210371589A1

公开(公告)日：2021-12-02

申请号：US17330407

申请日：2021-05-26

Applicant: ZHEJIANG GLORY HOME FURNISHINGS CO.,LTD

Inventor： Zehua DENG ,  Lei ZHANG ,  Guohao QIU ,  Hailing GUO ,  Qian ZHENG

IPC: C08G65/334 ,  C08G71/04

Abstract: A lignin-based block copolymer molecular-level combined polyether is based on lignosulfonate, a molecular chain of lignosulfonate is cut and embedded by using solvation effect of polyether polyol to form a molecular-level combined polyether that is polymerized and formed by aromatic polymer fragments of lignosulfonate and aliphatic polymer fragments of polyether polyol. The present invention uses a type of molecular mixing technology with a special structure to re-edit and splice the lignin molecular fragments of the hard segment on the microscopic level with the polymer polyols of the soft segment on the macroscopic level, to obtain a molecular-level combined polyether by a method of block copolymerization. Such a molecular-level combined polyether has dual characteristics of strong support and softness, which perfectly solves the problem how to balance strong support and softness of flexible polyurethane foam materials.

公开(公告)号：US11124604B2

公开(公告)日：2021-09-21

申请号：US16313516

申请日：2017-06-12

Applicant: Dow Global Technologies LLC

Inventor： Jean-Paul Masy ,  Oguz Türünç

IPC: C08G65/26 ,  B01J23/75 ,  C08G65/334

Abstract: Polyether diols characterized by a hydroxyl number of 56 or lower, high average functionality and high primary hydroxyl content are prepared by alkoxylating an unsaturated alcohol in multiple steps to form a polyether monol that contains 39% or more primary hydroxyl groups, and then reacting the polyether monol with a mercaptoalcohol that has a primary hydroxyl group.

公开(公告)号：US20210228764A1

公开(公告)日：2021-07-29

申请号：US17231190

申请日：2021-04-15

Applicant: BAXTER INTERNATIONAL INC. ,  BAXTER HEALTHCARE SA

Inventor： Hans Christian Hedrich ,  Joris Hoefinghoff ,  Woonza M. Rhee ,  Atsushi Edward Osawa

IPC: A61L15/42 ,  A61L15/58 ,  C08G65/334 ,  C09J171/02 ,  C08L71/02 ,  A61F13/15 ,  A61L15/22 ,  A61F13/02

Abstract: The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.

公开(公告)号：US11041090B2

公开(公告)日：2021-06-22

申请号：US16314630

申请日：2017-06-30

Applicant: FREIE UNIVERSITÄT BERLIN

Inventor： Rainer Haag ,  Marie Weinhart ,  Qiang Wei ,  Leixiao Yu

IPC: C09D171/02 ,  C12M1/00 ,  C08G83/00 ,  C09D201/00 ,  C08G65/00 ,  C09D201/06 ,  C09D201/02 ,  C08G65/22 ,  C08G65/334 ,  C09D5/00

Abstract: The disclosure relates to an amphiphilic block copolymer comprising a first block consisting of a polymeric hydrophilic domain, wherein the polymeric hydrophilic domain consists of a polyglycerol; an optional second block consisting of a hydrophobic domain and a first linker domain, wherein the second block is covalently bound to the first block via the first linker domain, an optional third block consisting of a catechol domain and a second linker domain, wherein the third block is covalently bound to the first block via the second linker domain; and a fourth block consisting of a crosslinking domain and a third linker domain, wherein the fourth block is covalently bound to the first block via the third linker domain, wherein the crosslinking domain comprises a reactive residue enabling a crosslinking between individual molecules of the amphiphilic block copolymer.

公开(公告)号：US20210155799A1

公开(公告)日：2021-05-27

申请号：US17263403

申请日：2019-07-29

Applicant: The University of Tokyo

Inventor： Takamasa SAKAI ,  Yuichi TEI

IPC: C08L71/02 ,  C08J9/28 ,  C08G65/334 ,  C08G65/333

Abstract: An object of the present invention is to provide a gel material including a solvophilic polymer having a μm-scale porous structure.
A polymer gel in which solvophilic polymer units are cross-linked with each other, wherein the polymer gel contains a solvent and has a three-dimensional network structure having two regions: a first region in which the polymer units are densely present and a second region in which the polymer units are sparsely present, and a mesh size composed of the first region is from 1 to 500 μm.

公开(公告)号：US11015026B2

公开(公告)日：2021-05-25

申请号：US16349803

申请日：2017-11-14

Applicant: BYK-CHEMIE GMBH

Inventor： Michael Bessel ,  Guillaume Wojciech Jaunky ,  Frederik Piestert ,  Carsten Nagel ,  Sandra Sabrina Meyer ,  Dennis Levering

IPC: C08G65/18 ,  C08G81/00 ,  B01F17/00 ,  C08J3/22 ,  C08K3/26 ,  C08K5/098 ,  C08K13/02 ,  C08L67/02 ,  C08G65/328 ,  C08G65/335 ,  C08G65/334 ,  C08G65/325 ,  C08G65/331 ,  C08K3/013

Abstract: The invention relates to polyesters of the following general formula, wherein the residues R1, R2, R3, R4, R5a (as a special case of residue R5), R6, R7 and R8 are free of carboxy, hydroxy, thiol, imino, and primary and secondary amino groups, the residues R5b (as a special case of R5) and R9 contain hydroxyl groups, 10 to 100 mol % of which can be present in salt form analogously to polymers or otherwise capped, u=0 or 1, v=1 to 60 and w=1 to 20. The invention further relates to wetting agents and dispersants that contain the aforementioned polyesters or consist thereof and to a method for producing said wetting agents and dispersants, to the use of the polyesters and reaction products of the method according to the invention as wetting agents and dispersants, and to compositions containing the polyesters, wetting agents and/or dispersants or reaction products of the method according to the invention and particulate solids.