GENETICALLY OPTIMISED MICROORGANISM FOR PRODUCING MOLECULES OF INTEREST

    公开(公告)号:US20220348897A1

    公开(公告)日:2022-11-03

    申请号:US17573877

    申请日:2022-01-12

    申请人: ENOBRAQ

    摘要: The invention concerns a genetically modified microorganism expressing a functional type I or II RuBisCO enzyme and a functional phosphoribulokinase (PRK), and in which the glycolysis pathway is at least partially inhibited, said microorganism being genetically modified so as to produce an exogenous molecule and/or to overproduce an endogenous molecule. According to the invention, the oxidative branch of the pentose phosphate pathway may also be at least partially inhibited. The invention also concerns the use of such a genetically modified microorganism for the production or overproduction of a molecule of interest and processes for the synthesis or bioconversion of molecules of interest.

    GENETICALLY OPTIMISED MICROORGANISM FOR PRODUCING MOLECULES OF INTEREST

    公开(公告)号:US20200277592A1

    公开(公告)日:2020-09-03

    申请号:US16480569

    申请日:2018-01-26

    申请人: ENOBRAQ

    摘要: The invention concerns a genetically modified microorganism expressing a functional type I or II RuBisCO enzyme and a functional phosphoribulokinase (PRK), and in which the glycolysis pathway is at least partially inhibited, said microorganism being genetically modified so as to produce an exogenous molecule and/or to overproduce an endogenous molecule. According to the invention, the oxidative branch of the pentose phosphate pathway may also be at least partially inhibited. The invention also concerns the use of such a genetically modified microorganism for the production or overproduction of a molecule of interest and processes for the synthesis or bioconversion of molecules of interest.