公开(公告)号：US20220142940A1

公开(公告)日：2022-05-12

申请号：US17433289

申请日：2020-02-21

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Naoto KAMAKURA ,  Akio TAKEUCHI ,  Hisakazu KURITA

IPC分类号： A61K9/70 ,  A61K47/20

摘要： The present invention provides a transdermal patch comprising an adhesive layer on a backing, wherein the adhesive layer comprises a drug, DMSO, and an adhesive base, and the adhesive base comprises a styrene-based thermoplastic elastomer having a triblock content of 35% to 65%.

公开(公告)号：US11246830B2

公开(公告)日：2022-02-15

申请号：US16975161

申请日：2019-02-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Shinya Matsumura ,  Toshihiro Nakanishi ,  Yasuhisa Kose

IPC分类号： A61K9/06 ,  A61K9/107 ,  A61K31/196 ,  A61K47/32 ,  A61K47/38 ,  A61K47/10 ,  A61K47/44

摘要： The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.

公开(公告)号：US11202764B2

公开(公告)日：2021-12-21

申请号：US16605268

申请日：2018-04-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Kazuya Kominami ,  Takito Shima ,  Naoyuki Uchida ,  Naoko Fujita ,  Shigeo Suzuki ,  Terumitsu Kaiho

IPC分类号： A61K9/70 ,  A61K47/12 ,  A61P25/04 ,  A61K31/485

摘要： A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.

公开(公告)号：US11123305B2

公开(公告)日：2021-09-21

申请号：US16008704

申请日：2018-06-14

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Atsushi Sonobe ,  Takashi Yasukochi ,  Yasunori Takada

IPC分类号： A61K9/70 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K31/407

摘要： In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.

公开(公告)号：US20210244925A1

公开(公告)日：2021-08-12

申请号：US16973553

申请日：2019-07-11

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Eisuke HATANAKA ,  Kazuki KURIYAMA ,  Naoki YAMAMOTO

IPC分类号： A61M37/00

摘要： A method of producing a microneedle sheet according to an embodiment includes: preparing a sheet having a first surface and a second surface; making a first cut in a range from the first surface to the second surface of the sheet to form a first outer edge that defines a tip end of the microneedle; and making, after forming the first outer edge, a second cut in a range from the first surface to the second surface of the sheet to form a second outer edge that defines the tip end of the microneedle, thereby forming the tip end of the microneedle.

公开(公告)号：US11020356B2

公开(公告)日：2021-06-01

申请号：US16474213

申请日：2017-12-26

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Ryo Tanaka ,  Hideaki Ohashi ,  Naruhide Miyoshi ,  Takito Shima ,  Naoko Fujita ,  Yasunari Michinaka

IPC分类号： A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

摘要： The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US10828480B2

公开(公告)日：2020-11-10

申请号：US15756234

申请日：2016-08-19

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Shinpei Nishimura ,  Seiji Tokumoto ,  Masafumi Ono

IPC分类号： A61M37/00

摘要： An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.

公开(公告)号：US10583121B2

公开(公告)日：2020-03-10

申请号：US15454066

申请日：2017-03-09

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

IPC分类号： A61K31/407 ,  A61K47/10 ,  A61K47/06 ,  A61K9/70 ,  A61K47/12 ,  A61K47/14 ,  A61M37/00 ,  A61K31/55

摘要： A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.

公开(公告)号：US20200009075A1

公开(公告)日：2020-01-09

申请号：US16483510

申请日：2018-02-15

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Keiichiro TSURUSHIMA ,  Masakazu SAEKI ,  Takaaki YOSHINAGA

IPC分类号： A61K9/70 ,  A61K47/42 ,  A61K47/32 ,  A61K47/10

摘要： A patch base comprises gelatin, polyvinyl alcohol, a methyl acrylate/2-ethylhexyl acrylate copolymer, and L-menthyl glyceryl ether, whereinrelative to the total mass of the base,the content of the gelatin is 1.5 to 6% by mass,the content of the polyvinyl alcohol is 0.5 to 8% by mass, andthe content of the methyl acrylate/2-ethylhexyl acrylate copolymer is 0.5 to 13% by mass.

公开(公告)号：US10525132B2

公开(公告)日：2020-01-07

申请号：US15568432

申请日：2016-04-27

申请人： HISAMITSU PHARMACEUTICAL CO., INC.

发明人： Kana Imamura ,  Tomohiro Shinoda ,  Shingo Somekawa ,  Yasunari Michinaka

IPC分类号： A61K47/12 ,  A61K31/216 ,  A61P17/00 ,  A61K9/00

摘要： The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.