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公开(公告)号：US06977143B1
公开(公告)日：2005-12-20
申请号：US10726919
申请日：2003-12-02
CPC分类号： G01N33/743 , Y10T436/108331 , Y10T436/200833
摘要： Provided are methods for determining the presence or amount of testosterone in a test sample, comprising ionizing all or a portion of the testosterone present in the sample to produce one or more testosterone ions that are detectable in a mass spectrometer. All or a portion of the testosterone present in the sample is ionized to produce one or more testosterone ions, which may be isolated and fragmented to produce precursor ions. A separately detectable internal testosterone standard can be provided in the sample. In a preferred embodiment, the reference is 2, 2, 4, 6, 6-d5 testosterone.
摘要翻译： 提供了用于确定测试样品中睾丸酮的存在或量的方法，其包括电离样品中存在的全部或部分睾酮以产生在质谱仪中可检测的一种或多种睾酮离子。 存在于样品中的全部或一部分睾酮被离子化以产生一种或多种睾丸酮离子，其可被分离并碎裂以产生前体离子。 可以在样品中提供可单独检测的内部睾酮标准品。 在优选的实施方案中，参考文献是2,4,6,6-d 5睾酮。
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92.发明申请公开(公告)号：US20050175499A1
公开(公告)日：2005-08-11
申请号：US10773752
申请日：2004-02-06
申请人： Michael Lewinski , William Meyer
发明人： Michael Lewinski , William Meyer
CPC分类号： A61L2/18
摘要： Provided are methods for reducing transfer of fluid between liquid samples subject to consecutive instrument controlled filter sampling. Transfer of fluid between subsequent samples is reduced by decontaminating surfaces of the instrument. The methods reduce sample contamination so that any remaining unused sample may be subject to diagnostic analysis without less concern that the outcome will be the result of sample cross-contamination.
摘要翻译： 提供了用于减少经受连续的仪器控制的过滤器取样的液体样品之间的流体转移的方法。 通过对仪器的表面进行净化来减少后续样品之间的流体转移。 这些方法可以减少样品污染，以便任何剩余的未使用样品可进行诊断分析，而不用担心结果将是样品交叉污染的结果。
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公开(公告)号：US12066446B2
公开(公告)日：2024-08-20
申请号：US18142153
申请日：2023-05-02
发明人： Brett Holmquist , Nigel Clarke , Anne Caston , Richard E. Reitz
IPC分类号： G01N33/82
CPC分类号： G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
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公开(公告)号：US11921122B2
公开(公告)日：2024-03-05
申请号：US18107947
申请日：2023-02-09
CPC分类号： G01N33/82 , G01N30/7233 , G01N30/72 , G01N2030/8813 , G01N2030/8822 , G01N2458/15 , G01N2560/00 , H01J49/00 , H01J49/004 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a vitamin D metabolite in a sample using mass spectrometry. The methods generally directed to ionizing a vitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. Also provided are methods to detect the presence or amount of two or more vitamin D metabolites in a single assay.
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公开(公告)号：US11875025B2
公开(公告)日：2024-01-16
申请号：US18139739
申请日：2023-04-26
发明人： Peter Wilkinson , Kerry O'Brien
IPC分类号： G06F3/0484 , G16H15/00 , G06F16/20 , G06F16/951 , G06F3/0482 , G06F3/04847 , G06F17/00 , G06T11/00 , G06F1/00
CPC分类号： G06F3/0484 , G06F3/0482 , G06F3/04847 , G06F16/20 , G06F16/951 , G16H15/00 , G06F1/00 , G06T11/00
摘要： Computer systems and methods may display multi-dimensional data sets in a dynamically-generated ocular view, which may show the relationship between data points in the different dimensions. For example, such a data set may include in one dimension results of one or more laboratory tests and, in another dimension, body systems or functions that the respective tests may relate to. The ocular view may depict the relationships between the tests and the systems. By being generated dynamically, moreover, the ocular view may be able to present this information for arbitrary sets of test results, without a template having been generated in advance to specify the layout of some particular combination of results.
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公开(公告)号：US11852636B2
公开(公告)日：2023-12-26
申请号：US18091726
申请日：2022-12-30
发明人： Brett Holmquist , Nigel Clarke
CPC分类号： G01N33/82 , G01N30/7233 , H01J49/004 , H01J49/145 , G01N2030/009 , G01N2030/027 , G01N2030/8813
摘要： The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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公开(公告)号：US20230280360A1
公开(公告)日：2023-09-07
申请号：US18316402
申请日：2023-05-12
发明人： Michael P. Caulfield , Richard E Reitz , Shuguang Li , Gloria Kwangja Lee , Ronald Krauss , Patricia J. Blanche , W. Henry Benner , Earl Cornell
CPC分类号： G01N33/92 , C07K1/14 , G01N15/0266 , G16H50/30 , Y10T436/25375 , Y10T436/25 , Y10T436/25125 , G16B99/00
摘要： The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.
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公开(公告)号：US11650216B2
公开(公告)日：2023-05-16
申请号：US16748234
申请日：2020-01-21
发明人： Brett Holmquist , Nigel Clarke , Anne Caston , Richard E. Reitz
CPC分类号： G01N33/82 , Y10T436/10 , Y10T436/20 , Y10T436/203332 , Y10T436/24
摘要： Provided are methods of detecting the presence or amount of a dihydroxyvitamin D metabolite in a sample using mass spectrometry. The methods generally comprise ionizing a dihydorxyvitamin D metabolite in a sample and detecting the amount of the ion to determine the presence or amount of the vitamin D metabolite in the sample. In certain preferred embodiments the methods include immunopurifying the dihydroxyvitamin D metabolites prior to mass spectrometry. Also provided are methods to detect the presence or amount of two or more dihydroxyvitamin D metabolites in a single assay.
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公开(公告)号：US11624737B2
公开(公告)日：2023-04-11
申请号：US17839298
申请日：2022-06-13
摘要： Provided are methods for determining the amount of lacosamide in a sample using mass spectrometry. The methods generally involve ionizing lacosamide in a sample and detecting and quantifying the amount of the ion to determine the amount of lacosamide in the sample.
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公开(公告)号：US11549954B2
公开(公告)日：2023-01-10
申请号：US17700320
申请日：2022-03-21
发明人： Brett Holmquist , Nigel Clarke
摘要： The invention relates to the detection of non-metabolized vitamin D. In a particular aspect, the invention relates to methods for detecting underivatized non-metabolized vitamin D by mass spectrometry.
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