公开(公告)号：US10423017B2

公开(公告)日：2019-09-24

申请号：US15517350

申请日：2015-10-15

Applicant: Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (C.N.R.S.) ,  Ecole Normale Superieure

Inventor： Jean-Francois Leger ,  Laurent Bourdieu ,  Stephane Dieudonne

IPC: G02F1/11 ,  G02F1/33 ,  G02B21/00 ,  G01N21/64 ,  G02B21/06

Abstract: Method for determining the characteristics of a system for generating at least one pattern of light, the method comprising: a) providing a desired pattern of light, b) expressing the amplitude and the phase of the output pulse of the system as a function of the input laser pulse and in function of the characteristics of the system to obtain a calculated output pulse, the input laser pulse having a duration below or equal to 1 nanosecond, c) determining at least one characteristic of the system by minimizing a distance between the calculated output pulse and the desired output laser pulse.

公开(公告)号：US20190204266A1

公开(公告)日：2019-07-04

申请号：US16151318

申请日：2018-10-03

Applicant: INSTITUTE CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Jean-Louis VIOVY ,  Valessa BARBIER

IPC: G01N27/447 ,  C08F265/10 ,  C08F290/04

CPC classification number: G01N27/44747 ,  C08F2/10 ,  C08F8/10 ,  C08F120/54 ,  C08F265/10 ,  C08F290/04 ,  C08F290/046 ,  C08F2810/30 ,  C08F2810/40 ,  C08F120/56 ,  C08F220/56

Abstract: An aqueous liquid medium for analyzing, purifying or separating species in an element having walls or for treating the walls of an element. The medium includes at least a polymer consisting of several polymeric segments. The polymer is of the irregular block-copolymer or irregular comb-like polymer type and has on the average at least three junction points between polymeric segments of different chemical or topological nature. The medium may be used in methods for analyzing, purifying or separating species and methods for treating an element to be contacted with a fluid and/or species contained in the fluid during preservation, transport, analysis, purification or separation of the fluid.

公开(公告)号：US20190117664A1

公开(公告)日：2019-04-25

申请号：US16212959

申请日：2018-12-07

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL (INSERM) ,  INSTITUT CURIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Sebastian AMIGORENA ,  Rhys ALLAN ,  Heidi SCHREIBER ,  Elina ZUEVA ,  Genevieve ALMOUZNI

IPC: A61K31/548 ,  G01N33/50 ,  G01N33/68 ,  C12Q1/48

Abstract: The present invention relates to methods and pharmaceutical composition for the treatment of T-helper type 2 (Th2)-mediated diseases. More particularly, the present invention relates to an inhibitor of the Suv39h1-HP1a silencing pathway for use in the treatment of a T-helper type 2 (Th2)-mediated disease, in particular allergic asthma.

公开(公告)号：US10247659B2

公开(公告)日：2019-04-02

申请号：US15305773

申请日：2015-04-24

Applicant: MENAPIC ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Arnaud Devos ,  Patrick Emery ,  Arnaud Le Louarn

IPC: H01S1/00 ,  H04B10/2537 ,  G01N21/17 ,  G01N21/63

Abstract: The present invention relates to a device (1) for characterizing an interface of a structure (6), said structure (6) comprising a solid first material and a second material, the materials being separated by said interface. The device (1) comprises: means (2) for generating a first mechanical wave; means (2) for forming Brillouin oscillations; means (10) for detecting time variation of the Brillouin oscillations; means (12) for responding to the time variation of the Brillouin oscillations to identify reflection of said first mechanical wave by said interface or transmission through said interface of a second mechanical wave interfering with the first mechanical wave; and means (13) for determining the variation in amplitude of the Brillouin oscillations before and after reflection or transmission by said interface. The invention also relates to a corresponding method of characterization.

公开(公告)号：US10202372B2

公开(公告)日：2019-02-12

申请号：US14421402

申请日：2013-08-16

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE D'ORLEANS

Inventor： Sylvain Routier ,  Hélène Benedetti ,  Frédéric Buron ,  Marie-Aude Hiebel ,  Thibault Saurat ,  Gérald Guillaumet

IPC: C07D471/04 ,  C07D413/14

Abstract: The present invention relates to compounds of the following general formula (I): wherein: R1 is notably a group —NRaRb, Ra and Rb forming together with the nitrogen atom onto which they are bound, a heterocycle comprising from 5 to 30 atoms, R2 is notably an aryl comprising from 5 to 30 atoms, and R3 is notably an alkenyl comprising from 1 to 20 carbon atoms.

公开(公告)号：US20190022122A1

公开(公告)日：2019-01-24

申请号：US16060895

申请日：2016-12-09

Applicant: Centre National de la Recherche Scientifique (C.N.R.S)

Inventor： José-Manuel CANCELA ,  Sabine DE LA PORTE ,  Antoine DE ZELICOURT

IPC: A61K31/7084 ,  A61K31/708 ,  A61K31/496 ,  A61P21/00

Abstract: The present invention relates to the field of medicine. It relates more particularly to the use of compounds for preventing and/or treating, in a subject, myopathy, typically muscular dystrophy or cardiomyopathy, or muscular trauma. The invention also relates to the compositions, in particular pharmaceutical compositions comprising such compounds, as well as their uses for preventing and/or treating muscular myopathy or trauma. The compounds and compositions according to the invention may typically be advantageously used to prevent and/or treat muscular dystrophy, cardiomyopathy or muscular trauma, preferably Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD) and/or a characteristic symptom or anomaly of DMD or BMD.

公开(公告)号：US10050283B2

公开(公告)日：2018-08-14

申请号：US14409155

申请日：2013-06-20

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE POITIERS

Inventor： Nicolas Alonso-Vante ,  Jiwei Ma ,  Aldo Gago

IPC: H01M4/92 ,  H01M4/88 ,  H01M8/1011 ,  H01M4/86

Abstract: The invention relates to a process for preparing nanoparticles of a catalyst for cathodic reduction and which is tolerant to methanol, these nanoparticles comprising a metallic center and a submonolayer of a chalcogen.

公开(公告)号：US09962799B2

公开(公告)日：2018-05-08

申请号：US14362091

申请日：2012-12-03

Applicant: ECOLE CENTRALE DE NANTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Jean-Yves Hascoet ,  Gilles Carabin ,  Pascal Mognol

IPC: B23K26/32 ,  B23K26/00 ,  B23K26/08 ,  B23P23/04 ,  B23P15/00 ,  B23P17/00 ,  B23K26/34 ,  B21D22/16 ,  B23Q39/02 ,  B23K37/04 ,  B23K37/047 ,  G05B19/4099 ,  B23K103/16

CPC classification number: B23P23/04 ,  B21D22/16 ,  B23K26/0093 ,  B23K26/083 ,  B23K26/0884 ,  B23K26/32 ,  B23K26/34 ,  B23K37/0408 ,  B23K37/047 ,  B23K2103/16 ,  B23K2103/172 ,  B23P15/00 ,  B23P17/00 ,  B23Q39/024 ,  G05B19/4099 ,  G05B2219/49018 ,  G05B2219/49328 ,  G05B2219/49358 ,  Y10T29/49982 ,  Y10T29/5176

Abstract: A machining method and apparatus for machining a part comprises a machining head and motorized axes comprising a rotary axis for displacing the machining head in a working space. Apparatus comprises a mechanism for positioning a part and holding it in position the working space. The machining head comprises a support for supporting a material shaping tool and a supply device for supplying material.

公开(公告)号：US09861971B2

公开(公告)日：2018-01-09

申请号：US15001235

申请日：2016-01-19

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Marc Taillefer ,  Ning Xia ,  Florian Monnier ,  Anis Tlili

IPC: B01J31/26 ,  B01J31/30 ,  B01J31/22 ,  C07C41/16 ,  C07C209/62 ,  C07C231/08 ,  C07C249/02

CPC classification number: B01J31/26 ,  B01J31/1805 ,  B01J31/2204 ,  B01J31/2208 ,  B01J31/2234 ,  B01J31/30 ,  B01J2231/4205 ,  B01J2231/4277 ,  B01J2231/4283 ,  B01J2231/4288 ,  B01J2231/4294 ,  B01J2531/16 ,  B01J2531/842 ,  C07B37/04 ,  C07C41/16 ,  C07C209/62 ,  C07C231/08 ,  C07C249/02 ,  C07C43/275 ,  C07C233/07 ,  C07C211/46 ,  C07C251/24

Abstract: The present invention concerns a process for creating a Carbon-Carbon bond (C—C) or a Carbon-Heteroatom bond (C—HE) by reacting a compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C—HE bond, wherein the reaction takes place in the presence of an effective quantity of a. a catalytic system comprising a ligand and at least a metal-based catalyst, such a metal catalyst being chosen among iron or copper compounds proviso that only a single metal is present.

公开(公告)号：US09833492B2

公开(公告)日：2017-12-05

申请号：US14713477

申请日：2015-05-15

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITÉ PARIS-SUD

Inventor： Jerome Estaquier ,  Mireille Laforge ,  Anna Senik

IPC: A61K31/47 ,  A61K38/05 ,  A61K45/06 ,  A61K31/404 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/7072 ,  A61K38/00 ,  C07K5/062

CPC classification number: A61K38/05 ,  A61K31/404 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/496 ,  A61K31/7072 ,  A61K38/005 ,  A61K45/06 ,  C07K5/06052 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/463 ,  Y02A50/465

Abstract: A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxyl)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.