公开(公告)号：US20090104660A1

公开(公告)日：2009-04-23

申请号：US10576068

申请日：2004-10-14

Applicant: Sung Youb Jung ,  Jin Sun Kim ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Sung Youb Jung ,  Jin Sun Kim ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: C12P21/04 ,  C12N15/00 ,  C12N1/21

CPC classification number: C12P21/02 ,  C07K16/00 ,  C07K16/241 ,  C07K2317/55 ,  C07K2319/00 ,  C07K2319/02 ,  C12N15/70

Abstract: A recombinant expression vector capable of expressing and secreting an antibody fragment fused with E. coli thermostable enterotoxin signal sequence derivative or E. coli outer membrane protein A (Omp A) signal sequence in the form of a soluble heterozygote protein is used to mass-produce the antibody fragment by culturing a microorganism transformed with the expression vector in a medium and collecting the antibody fragment secreted from the transformed microorganism into the medium

Abstract translation: 能够表达和分泌与大肠杆菌热稳定性肠毒素信号序列衍生物或可溶性杂合子蛋白质形式的大肠杆菌外膜蛋白A（Omp A）信号序列融合的抗体片段的重组表达载体用于批量生产 通过在培养基中培养用表达载体转化的微生物并将从转化的微生物分泌的抗体片段收集到培养基中的抗体片段

公开(公告)号：US07470707B2

公开(公告)日：2008-12-30

申请号：US10971028

申请日：2004-10-25

Applicant: Sangmin Yun ,  Eun Sook Kim ,  Hee Seock Kim ,  Bo Sung Kwon ,  Cheol Kyung Kim ,  Han Kyong Kim ,  Kwee-Hyun Suh ,  Gwan Sun Lee

Inventor： Sangmin Yun ,  Eun Sook Kim ,  Hee Seock Kim ,  Bo Sung Kwon ,  Cheol Kyung Kim ,  Han Kyong Kim ,  Kwee-Hyun Suh ,  Gwan Sun Lee

IPC: C07D495/04 ,  A61K31/4365

CPC classification number: C07D495/04

Abstract: A crystalline clopidogrel naphthalenesulfonate or a hydrate thereof, a method for preparing same, and a pharmaceutical composition containing same are provided.

Abstract translation: 提供结晶氯吡格雷萘磺酸盐或其水合物，其制备方法和含有它们的药物组合物。

公开(公告)号：US20080293106A1

公开(公告)日：2008-11-27

申请号：US12063379

申请日：2006-08-16

Applicant: Sung youb Jung ,  Jin Sun Kim ,  Jin hwan Shin ,  Se-Chang Kwon ,  Gwan-Sun Lee ,  Dae hae Song

Inventor： Sung youb Jung ,  Jin Sun Kim ,  Jin hwan Shin ,  Se-Chang Kwon ,  Gwan-Sun Lee ,  Dae hae Song

IPC: C12P21/00 ,  C07K16/00

CPC classification number: C07K16/00 ,  A61K47/6811 ,  A61K47/6835 ,  C07K2317/41 ,  C07K2317/52

Abstract: Disclosed is a method for the mass production of a monomeric or dimeric immunoglobulin Fc region, free of initial methionine residues, using a recombinant expression vector comprising a nucleotide sequence coding for a recombinant immunoglobulin Fc region comprising an immunoglobulin Fc region linked at the N-terminus thereof to an immunoglobulin Fc region via a peptide bond.

Abstract translation: 公开了使用包含编码重组免疫球蛋白Fc区的核苷酸序列的重组表达载体大规模生产不含初始甲硫氨酸残基的方法，所述重组表达载体包含在N末端连接的免疫球蛋白Fc区 通过肽键与免疫球蛋白Fc区连接。

公开(公告)号：US20080076725A1

公开(公告)日：2008-03-27

申请号：US11681245

申请日：2007-03-02

Applicant: Kwee-Hyun SUH ,  Gi-Jeong Kim ,  Sang-Min Yoon ,  Mi-Ra Seong ,  Gwan-Sun Lee

Inventor： Kwee-Hyun SUH ,  Gi-Jeong Kim ,  Sang-Min Yoon ,  Mi-Ra Seong ,  Gwan-Sun Lee

IPC: A61K31/7052 ,  A61P31/00

CPC classification number: C07D413/14 ,  A61K31/7028

Abstract: The present invention relates to a clathrate of azithromycin hydrate with 1,2-propyleneglycol of formula (I), a method for the manufacture thereof, and a pharmaceutical composition containing same. The inventive compound is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a medicine for treating various microbial infections. wherein m ranges from 1 to 2 and n, from 0.30 to 0.45.

Abstract translation: 本发明涉及阿奇霉素水合物与式（I）的1,2-丙二醇的包合物，其制备方法和含有它的药物组合物。 本发明化合物比本领域已知的阿奇霉素水合物或晶体吸湿性好得多，因此可用于制备用于治疗各种微生物感染的药物。 其中m为1至2，n为0.30至0.45。

公开(公告)号：US07205394B2

公开(公告)日：2007-04-17

申请号：US10476016

申请日：2002-04-25

Applicant: Kwee-Hyun Suh ,  Gi-Jeong Kim ,  Sang-Min Yoon ,  Mi-Ra Seong ,  Gwan-Sun Lee

Inventor： Kwee-Hyun Suh ,  Gi-Jeong Kim ,  Sang-Min Yoon ,  Mi-Ra Seong ,  Gwan-Sun Lee

IPC: C07H1/00 ,  C07H17/08

CPC classification number: C07D413/14 ,  A61K31/7028

Abstract: A clathrate of azithromycin hydrate with 1,2-propyleneglycol is much less hygroscopic than azithromycin hydrate or crystals known in the art, therefore, it can be useful for the preparation of a medicine for treating various microbial infections.

Abstract translation: 具有1,2-丙二醇的阿奇霉素水合物的包合物比本领域已知的阿奇霉素水合物或晶体吸湿性好得多，因此可用于制备用于治疗各种微生物感染的药物。

公开(公告)号：US07202360B2

公开(公告)日：2007-04-10

申请号：US10531299

申请日：2003-10-17

Applicant: Nam-Du Kim ,  Jae-Heon Lee ,  Moon-Sub Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

Inventor： Nam-Du Kim ,  Jae-Heon Lee ,  Moon-Sub Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

IPC: C07D239/70 ,  A01N43/90 ,  A61K31/519 ,  C07D211/18

CPC classification number: C07D471/04

Abstract: Risperidone is prepared in a high yield by reacting 2,4-difluorophenyl(4-piperidinyl)methanone oxime hydrochloride and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one in an aqueous alkali hydroxide solution having an alkali hydroxide concentration in the range of 20 to 40%.

Abstract translation: 通过使2,4-二氟苯基（4-哌啶基）甲酮肟盐酸盐和3-（2-氯乙基）-6,7,8,9-四氢-2-甲基-4H-吡啶并[1 ，2-a]嘧啶-4-酮在碱金属氢氧化物浓度为20〜40％范围内的碱金属氢氧化物水溶液中。

公开(公告)号：US06936625B2

公开(公告)日：2005-08-30

申请号：US10473479

申请日：2002-03-28

Applicant: Young-Ho Moon ,  Nam-Du Kim ,  Kyung-Ik Lee ,  Gwan-Sun Lee ,  Jong-Soo Woo

Inventor： Young-Ho Moon ,  Nam-Du Kim ,  Kyung-Ik Lee ,  Gwan-Sun Lee ,  Jong-Soo Woo

IPC: C07D211/84 ,  A61K31/4422 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  C07C309/07 ,  C07D211/90 ,  A61K31/4418 ,  C07D213/80

CPC classification number: C07D211/90

Abstract: Amlodipine camsylate of the present invention is a crystalline salt of amlodipine suitable for pharmaceutical formulation, which is prepared by using low toxic camphor sulfonic acid to meet required pharmaceutical properties for treating cardiovascular diseases.

Abstract translation: 本发明的氨氯地平樟脑磺酸盐是适用于药物制剂的氨氯地平的结晶盐，其通过使用低毒樟脑磺酸来满足治疗心血管疾病所需的药物性质来制备。

公开(公告)号：US20050176108A1

公开(公告)日：2005-08-11

申请号：US10659195

申请日：2003-09-09

Applicant: Young-Min Kim ,  Dae-Jin Kim ,  Sung-Min Bae ,  Chang-Ki Lim ,  Se-Chang Kwon ,  Gwan-Sun Lee

Inventor： Young-Min Kim ,  Dae-Jin Kim ,  Sung-Min Bae ,  Chang-Ki Lim ,  Se-Chang Kwon ,  Gwan-Sun Lee

IPC: C07K19/00 ,  A61K47/48 ,  C07K16/00 ,  A61K39/395 ,  C07K16/46 ,  C12P21/04

CPC classification number: C07K16/00 ,  A61K47/60 ,  A61K47/643 ,  A61K47/6811 ,  A61K47/6883

Abstract: A protein conjugate having a prolonged in vivo half-life of a physiological activity, comprising i) a physiologically active polypeptide, ii) a biocompatible non-peptidic polymer, and iii) an immunoglobulin, is useful for the development of a peptide drug due to the enhanced in vivo stability and prolonged half-life in blood, while reducing the possibility of inducing an immune response.

Abstract translation: 具有延长的生理活性的体内半衰期的蛋白质缀合物，其包含i）生理活性多肽，ii）生物相容性非肽聚合物，和iii）免疫球蛋白，可用于开发肽药物，因为 提高体内稳定性和延长血液半衰期，同时降低诱导免疫应答的可能性。

公开(公告)号：US06809188B1

公开(公告)日：2004-10-26

申请号：US10129419

申请日：2002-05-01

Applicant: Kwee-Hyun Suh ,  Mi-Ra Seong ,  Nam-Du Kim ,  Gwan-Sun Lee

Inventor： Kwee-Hyun Suh ,  Mi-Ra Seong ,  Nam-Du Kim ,  Gwan-Sun Lee

IPC: C07H1708

CPC classification number: C07H17/08

Abstract: Clarithromycin can be easily prepared by reacting erythromycin A N-oxide with a methylating agent to obtain 6-O-methylerythromycin A N-oxide; and treating 6-O-methylerythromycin A N-oxide obtained above with a reducing agent in a high yield.

Abstract translation: 红霉素A N-氧化物与甲基化剂反应可以容易地制备克拉霉素，得到6-O-甲基红霉素A N-氧化物; 并用还原剂以高产率处理上述得到的6-O-甲基红霉素A N-氧化物。

公开(公告)号：US06506886B1

公开(公告)日：2003-01-14

申请号：US09786636

申请日：2001-03-07

Applicant: Tae-Suk Lee ,  Ju-Cheol Lee ,  Kyoung-Ik Lee ,  Gwan-Sun Lee ,  Wan-Joo Kim

Inventor： Tae-Suk Lee ,  Ju-Cheol Lee ,  Kyoung-Ik Lee ,  Gwan-Sun Lee ,  Wan-Joo Kim

IPC: C07M100

CPC classification number: C07H17/08

Abstract: Form II crystals of clarithromycin can be easily prepared by treating clarithromycin of different crystal forms with water or with a mixture of water and a water-immiscible organic solvent and isolating treated crystals by filtration.

Abstract translation: 克拉霉素II型晶体可以通过用水或水与水不混溶的有机溶剂的混合物处理不同晶型的克拉霉素并通过过滤分离处理的晶体来容易地制备。