公开(公告)号：USD1066041S1

公开(公告)日：2025-03-11

申请号：US29916785

申请日：2023-11-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Tatsuaki Sakai ,  Kei Nishioka ,  Satoshi Ito

公开(公告)号：US20250064754A1

公开(公告)日：2025-02-27

申请号：US18941163

申请日：2024-11-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryo TANAKA ,  Hideaki OHASHI ,  Naruhide MIYOSHI ,  Takito SHIMA ,  Naoko FUJITA ,  Yasunari MICHINAKA

IPC: A61K9/70 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.

公开(公告)号：US12186287B2

公开(公告)日：2025-01-07

申请号：US18083793

申请日：2022-12-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kentaro Nakashima ,  Yusuke Tanaka ,  Keiichiro Tsurushima

IPC: A61K31/167 ,  A61K9/70 ,  A61K47/10

Abstract: Disclosed is a patch comprising an adhesive layer on a backing layer, wherein the adhesive layer comprises lidocaine or a pharmaceutically acceptable salt thereof, propylene glycol, a rubber adhesive base and a terpene resin, wherein the content of the lidocaine or a pharmaceutically acceptable salt thereof in the adhesive layer in terms of free form is 2 mass % to 6 mass % with respect to the total mass of the adhesive layer, wherein the ratio of the mass of the lidocaine or a pharmaceutically acceptable salt thereof in terms of free form to the mass of propylene glycol in the adhesive layer is 1:0.6 to 1:1.8, and wherein the content of the terpene resin in the adhesive layer is 5 mass % to 18 mass % with respect to a total mass of the adhesive layer.

公开(公告)号：US12172819B2

公开(公告)日：2024-12-24

申请号：US18040188

申请日：2021-07-30

Applicant: TOPPAN INC. ,  HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuyoshi Okada ,  Yoshikazu Kuwano ,  Hiroshi Oishi ,  Tetsuhiro Kawano

IPC: B65D77/38 ,  B65D65/40 ,  B65D77/12

Abstract: A packaging bag includes a cutting guide band extending along a transverse direction. The cutting guide band includes, a first guide band having first cut lines that are inclined at a predetermined angle with respect to the transverse direction; a second guide band having second cut lines that are inclined at a predetermined angle in a direction opposite a direction of the first cut lines with respect to the transverse direction; and a third guide band having third cut lines that are inclined at a predetermined angle in the same direction as the direction of the first cut lines with respect to the transverse direction. The cutting guide band has a fourth cut line between the first guide band and the second guide band and/or between the second guide band and the third guide band, the fourth cut line being perforated and extending along the transverse direction.

公开(公告)号：USD1000951S1

公开(公告)日：2023-10-10

申请号：US29826061

申请日：2022-02-09

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Sayaka Mochizuki ,  Shigeo Kusumi

Abstract: The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee.
FIG. 1 is a front view of a packing box of the present invention;
FIG. 2 is a rear view thereof;
FIG. 3 is a top plan view thereof;
FIG. 4 is a bottom plan view thereof;
FIG. 5 is a right side view thereof;
FIG. 6 is a left side view thereof;
FIG. 7 is a front perspective view thereof; and,
FIG. 8 is a rear perspective view thereof.
The broken lines in the drawings are shown for the purpose of illustrating parts of the article that form no part of the claimed design.
Salonpas® is a registered trademark from Hisamitsu Pharmaceutical Co., Inc. forming part of the claimed design.

公开(公告)号：USD985232S1

公开(公告)日：2023-05-09

申请号：US29740921

申请日：2020-07-08

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Akinori Sanada

Abstract: FIG. 1 is a front perspective view of a character costume showing the new design;
FIG. 2 is a rear perspective view thereof;
FIG. 3 is a front view thereof,
FIG. 4 is a rear view thereof;
FIG. 5 is atop plan view thereof;
FIG. 6 is a bottom view thereof;
FIG. 7 is a right side view thereof; and,
FIG. 8 is a left side view thereof.
The broken lines in the figures show portions of the character costume that form no part of the claimed design.

公开(公告)号：US11590106B2

公开(公告)日：2023-02-28

申请号：US17281623

申请日：2019-09-25

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Masaki Yukuhiro ,  Yuka Takagi ,  Yasunari Michinaka

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/02 ,  A61K47/12 ,  A61K47/32

Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.

公开(公告)号：US20230034383A1

公开(公告)日：2023-02-02

申请号：US17381294

申请日：2021-07-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yuka TAKAGI ,  Kazuya ISHIDA ,  Ryoma TAMURA ,  Takao KUROKAWA ,  Yasunari MICHINAKA

IPC: A61K31/407 ,  A61K9/70 ,  A61K47/06

Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 μg/cm2 in terms of free form.

公开(公告)号：US11464956B2

公开(公告)日：2022-10-11

申请号：US16488456

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Kazuya Machida ,  Shinpei Nishimura ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K9/00 ,  A61K9/70

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 μm, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.

公开(公告)号：US20220125626A1

公开(公告)日：2022-04-28

申请号：US17430035

申请日：2020-02-14

Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.

Inventor： Kentaro NAKASHIMA ,  Keiichiro TSURUSHIMA ,  Takaaki YOSHINAGA

IPC: A61F7/02 ,  C09J129/04 ,  C08K5/12

Abstract: A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.