Abstract:
A mutant HSV-1 (referred to herein as KOS-NA) was generated. KOS-NA contains novel mutations in the UL39 gene, which encodes for a protein that is a large subunit of ribonucleotide reductase (i.e., ICP6). These UL39 mutations were found to alter two amino acids in ICP6 (R950H and L393P) and are responsible for attenuation of KOS-NA in vivo, and resulted in diminished ICP6 protein levels. These novel UL39 mutations regulate the expression and/or stability of ICP6 and severely impact HSV-1 pathogenesis. Mutant HSV viruses containing these mutations appear to protect against HSV infection and can serve as therapeutic vaccines to help combat preexisting HSV infection in infected individuals.
Abstract:
Systems, methods, apparatuses and computer-readable storage media for navigating an unmanned aerial vehicle (UAV) using signals of opportunity are disclosed. The UAV may include a receiver for detecting a plurality of signals at two or more receiver elements. The UAV may estimate an angle of arrival (AoA) for at least two signals of the plurality of signals, and may estimate a position of the receiver based, at least in part, on the AoA for each of the at least two signals. Known locations of the transmitters that are transmitting the at least two signals may be used in conjunction with the AoAs to determine the estimate of the position of the receiver. More than two signals may be used to localize the estimated position of the receiver.
Abstract:
Provided herein are stable enalapril powder compositions for oral liquid formulation. Also provided herein are methods of using enalapril oral liquid formulations for the treatment of certain diseases including hypertension, heart failure and asymptomatic left ventricular dysfunction.
Abstract:
The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These compounds provide high potency of agonistic activities with human, other than murine, TLR2, and are useful as vaccine adjuvants. Vaccines are perhaps one of the most successful medical interventions against infectious disease.
Abstract:
A family of Radar energy Absorbing Deformable Low Drag Vortex Generators (RAD-LDVG) is described herein. This family of devices are fabricated in such a way that it can conform to aircraft surface features while reducing radar returns from structural details. Vortex generators (VGs) are typically used to reattach or smooth gross flowfields over aircraft surfaces. By doing so, an airfoil or wing can maintain attached flow at higher angles of attack and/or higher lift coefficients than one without the VGs. These devices are also used to reattach and/or smooth flows that encounter crossflow-induced instabilities and/or adverse pressure gradients on the upper surfaces of wings or near aircraft boattails. Other uses include reduction of buffet, vibration, flutter, cavity resonance or general bluff-body pressure drag reduction. Although conventional rigid VGs do generate vortical aerodynamic structures, two major problems are often experienced: i.) the inability to conform to curved surfaces, ii.) the generation of radar cross-section spikes produced by the VGs themselves.
Abstract:
A flat-stock aerial vehicle includes a body having a plurality of flat-stock sheets connected to one another, at least one motor, and at least three aerodynamic propulsors driven by the at least one motor. The aerodynamic propulsors can provide lifting thrust, pitch, yaw, and roll control in both helicopter-like hover flight and airplane-like translational flight.
Abstract:
This invention relates generally to the discovery of a method of inhibiting, preventing or treating bacterial infections. The invention also relates to a method of inhibiting bacterial capsule biogenesis.
Abstract:
A laboratory fume hood system for cooling at least one laboratory device located in an interior work area comprises a heat exchanger system having a heat exchanger in thermal communication with a primary fluid loop containing chilled fluid and a secondary fluid loop containing a cooling fluid which is in thermal communication the laboratory device. The primary fluid loop is located behind the fume hood wall and not in the interior work area.
Abstract:
Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
Abstract:
Described herein are compounds, pharmaceutical compositions and methods for treating a respiratory syncytial virus infection in a subject, or for inhibiting replication of respiratory syncytial virus.