公开(公告)号：US11746144B2

公开(公告)日：2023-09-05

申请号：US17375601

申请日：2021-07-14

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  CEDARS-SINAI MEDICAL CENTER

Inventor： Ivet Bahar ,  Hongying Cheng ,  She Zhang ,  Rebecca Porritt ,  Moshe Arditi

IPC: C07K16/12 ,  A61K39/215 ,  A61P31/14

CPC classification number: C07K16/1271 ,  A61K39/215 ,  A61P31/14 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

Abstract: Provided herein are methods of treating a COVID-19 infection in a subject, comprising administering to the subject an effective amount of a composition that reduces the superantigen character of SARS-CoV-2 Spike protein. In some embodiments, the compositions are mimetic peptides of the superantigen region. In some embodiments, the compositions are humanized antibodies, such as humanized mAb 6D3, that bind to the superantigen region.

公开(公告)号：US11730005B2

公开(公告)日：2023-08-15

申请号：US17330865

申请日：2021-05-26

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Hong Koo Kim ,  Daud Hasan Emon

IPC: H10K50/11 ,  H10K50/115 ,  H10K50/00 ,  H10K50/15 ,  H10K50/18 ,  H10K50/80 ,  H10K71/00 ,  H10K101/40 ,  H10K50/16 ,  H10K59/122 ,  H10K77/10 ,  H10K85/10

CPC classification number: H10K50/00 ,  H10K50/11 ,  H10K50/115 ,  H10K50/15 ,  H10K50/18 ,  H10K50/80 ,  H10K71/00 ,  H10K50/16 ,  H10K59/122 ,  H10K77/10 ,  H10K85/1135 ,  H10K85/146 ,  H10K2101/40

Abstract: Various light emitting diode device embodiments that include emissive material elements, e.g., core-shell quantum dots, that are either (i) provided in nanoscale holes provided in an insulating layer positioned between an electron supply/transport layer and a hole supply/transport layer, or (ii) provided on a suspension layer positioned above and covering a nanoscale hole in such an insulating layer. Also, various methods of making such light emitting diode devices, including lithographic and non-lithographic methods.

公开(公告)号：US11728543B2

公开(公告)日：2023-08-15

申请号：US16628837

申请日：2018-07-09

Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Prashant N. Kumta ,  Bharat Gattu ,  Moni Kanchan Datta ,  Oleg Velikokhatnyi ,  Pavithra Murugavel Shanthi ,  Prashanth Jampani Hanumantha

IPC: H01M50/44 ,  D01D5/00 ,  D01F1/10 ,  H01M10/052 ,  H01M10/0565 ,  H01M50/403 ,  H01M50/431 ,  H01M50/489 ,  H01M50/426 ,  H01M50/434 ,  H01M50/497 ,  H01M50/40 ,  H01M10/0525

CPC classification number: H01M50/44 ,  D01D5/003 ,  D01F1/10 ,  H01M10/052 ,  H01M10/0565 ,  H01M50/40 ,  H01M50/403 ,  H01M50/426 ,  H01M50/431 ,  H01M50/434 ,  H01M50/489 ,  H01M50/497 ,  H01M10/0525 ,  H01M2300/0082 ,  H01M2300/0094

Abstract: The invention relates to lithium ion batteries and, more particularly, to lithium ion conducting composite polymer electrolyte separators. The separators include a nanofiber mat composed of electrospun nanofibers. The nanofibers include a polymer having one or more polar halogen groups, a lithium-containing solid or liquid electrolyte and nanoparticle filler. The polymer, electrolyte and filler are combined to form a solution that is subjected to the electro-spinning process to produce electrospun nanofibers in the form of the mat.

公开(公告)号：US20230241019A1

公开(公告)日：2023-08-03

申请号：US18009935

申请日：2021-04-20

Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education ,  The Regents of the University of Michigan

Inventor： Francisco J. Schopfer ,  Bruce A. Freeman ,  Yang Zhao ,  Yuqing E. Chen ,  Jifeng Zhang

IPC: A61K31/231 ,  A61P9/14

CPC classification number: A61K31/231 ,  A61P9/14

Abstract: A method comprising administering to a subject having an aneurysm, suspected of having an aneurysm, or at risk of developing an aneurysm, a therapeutically effective amount of a compound selected from (i) a nitroalkene fatty acid, (ii) an unsaturated fatty acid having an electron withdrawing group, a leaving group, and a carbon-carbon double bond disposed between the electron withdrawing group and the leaving group, (iii) a thiolated nitro fatty acid, (iv) a dicarboxylic acid compound containing an electron withdrawing group, or a mixture of at least two of (i)-(iv).

公开(公告)号：US20230228689A1

公开(公告)日：2023-07-20

申请号：US18061215

申请日：2022-12-02

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： SARAH L. HEMLER ,  KURT E. BESCHORNER

IPC: G01N21/88 ,  G02B6/42 ,  H04N23/56 ,  G06T7/00 ,  G06T7/62

CPC classification number: G01N21/8851 ,  G02B6/42 ,  G06T7/0002 ,  G06T7/62 ,  H04N23/56 ,  G01N2021/8874

Abstract: A system for monitoring the tread of a shoe includes a frame member, a waveguide structured to support the shoe when an outer sole of shoe is in contact with a surface of the waveguide, a light source structured to provide light within an edge of the waveguide such that the light will be internally reflected within the waveguide, and an imaging device structured and configured to generate an image of the outer sole of the shoe when the outer sole of shoe is in contact with the waveguide and the light is being provided within the waveguide. The system also includes a controller structured and configured to: (i) receive image data based on the image of the outer sole; (ii) determine from the image data a largest worn region size for the shoe; and (iii) determine a slip risk for the shoe based on the largest worn region size.

公开(公告)号：US11696976B2

公开(公告)日：2023-07-11

申请号：US15750219

申请日：2016-08-22

Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Prashant N. Kumta ,  Abhijit Roy ,  Da-Tren Chou ,  Daeho Hong ,  Vijay S. Gorantla

IPC: A61L31/14 ,  A61L31/02 ,  C22C23/04

CPC classification number: A61L31/148 ,  A61L31/022 ,  C22C23/04 ,  A61L2430/02

Abstract: The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities due to production, and are prepared by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.

公开(公告)号：US20230211053A1

公开(公告)日：2023-07-06

申请号：US18113676

申请日：2023-02-24

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： PRASHANT N. KUMTA ,  SUNG JAE CHUNG ,  PARTHA SAHA ,  OLEG VELIKOKHATNYI ,  MONI KANCHAN DATTA ,  DAE HO HONG ,  DA-TREN CHOU

IPC: A61L31/02 ,  A61L31/14

CPC classification number: A61L31/022 ,  A61L31/148 ,  C22C38/002

Abstract: The invention relates to biodegradable iron alloy-containing compositions for use in preparing medical devices. In addition, biodegradable crystalline and amorphous compositions of the invention exhibit properties that make them suitable for use as medical devices for implantation into a body of a patient. The compositions include elemental iron and one or more elements selected from manganese, magnesium, zirconium, zinc and calcium. The compositions can be prepared using a high energy milling technique. The resulting compositions and the devices formed therefrom are useful in various surgical procedures, such as but not limited to orthopedic, craniofacial and cardiovascular.

公开(公告)号：US11693014B2

公开(公告)日：2023-07-04

申请号：US16743610

申请日：2020-01-15

Applicant: University of Pittsburgh—of the Commonwealth System of Higher Education

Inventor： Kai Singbartl ,  John A. Kellum, Jr.

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/495 ,  G01N2333/70578 ,  G01N2400/40 ,  G01N2800/347 ,  G01N2800/50

Abstract: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor β1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.

公开(公告)号：US11673916B2

公开(公告)日：2023-06-13

申请号：US17494605

申请日：2021-10-05

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education

Inventor： Elias Aizenman ,  Jason Arnold Justice ,  Anthony John Schulien

IPC: C07K7/06 ,  A61P25/00 ,  A61K38/00

CPC classification number: C07K7/06 ,  A61P25/00 ,  A61K38/00 ,  C07K2319/10

Abstract: Neuroprotective peptides derived from the voltage-gated potassium channel Kv2.2 are described. The peptides promote dispersal of the cognate channel Kv2.1 in neurons, thereby blocking pro-apoptotic potassium efflux, and preserving cell viability after apoptotic injury. Methods of preventing and treating neuronal damage, such as neuronal damage following ischemic stroke, by administering the neuroprotective peptides are described. Fusion of the neuroprotective peptides to a cell-penetrating peptide to promote cellular uptake is also described.

公开(公告)号：US11673853B2

公开(公告)日：2023-06-13

申请号：US17313577

申请日：2021-05-06

Applicant: University of Pittsburgh—Of the Commonwealth System of Higher Education ,  The United States as represented by the Department of Veterans Affairs

Inventor： Beibei Chen ,  Rama K. Mallampalli ,  Yuan Liu

IPC: C07C217/34 ,  C07C215/08 ,  C07C215/18 ,  C07D205/04 ,  C07D217/04 ,  C07D311/88 ,  A61P29/00

CPC classification number: C07C217/34 ,  A61P29/00 ,  C07C215/08 ,  C07C215/18 ,  C07D205/04 ,  C07D217/04 ,  C07D311/88

Abstract: Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.