公开(公告)号：US20070292540A1

公开(公告)日：2007-12-20

申请号：US11690627

申请日：2007-03-23

申请人： Robert Gow ,  Dan Li ,  George Sypert ,  Randall Alberte

发明人： Robert Gow ,  Dan Li ,  George Sypert ,  Randall Alberte

IPC分类号： A61K36/54 ,  A23L1/28 ,  A61P39/06 ,  C07C29/00 ,  C07C39/12 ,  C07C39/18 ,  C07C47/54 ,  C07C63/04 ,  C07D311/04 ,  C07H17/02

CPC分类号： C07C47/232 ,  A23L27/12 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/54 ,  C07C29/76 ,  C07C31/125 ,  C07C33/02 ,  C07C33/14 ,  C07C33/32 ,  C07C35/30 ,  C07C45/78 ,  C07C47/27 ,  C07C47/277 ,  C07C47/54 ,  C07C51/47 ,  C07C67/56 ,  C07D311/40 ,  C07H17/02 ,  Y02P20/544 ,  C07C57/44 ,  C07C69/618 ,  C07C69/007 ,  A23V2200/15 ,  A23V2250/708 ,  A23V2250/264 ,  C07C69/157

摘要： The present invention relates to extracts of cinnamon species plant material prepared by supercritical CO2 extractions methods.

摘要翻译： 本发明涉及通过超临界CO 2萃取方法制备的肉桂种植物材料的提取物。

公开(公告)号：US20070292443A1

公开(公告)日：2007-12-20

申请号：US11810590

申请日：2007-06-06

申请人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

发明人： Ying Wang ,  Yingmei Zhang ,  Wenling Han ,  Dalong Ma ,  Yanan Liu ,  Caihua Yin ,  Linjie Tian ,  Dan Li

IPC分类号： A61K39/395 ,  A61K38/17 ,  C07K16/46 ,  C07K14/16

CPC分类号： C07K14/521 ,  A61K38/00 ,  C07K16/18 ,  C07K2317/77

摘要： Polypeptides having an amino acid sequence of SEQ ID NO: 2, and having amino acid residues 9 to 27 of SEQ ID NO: 2 are disclosed, which are together named C-terminal polypeptides of CKLF1. Also disclosed is a pharmaceutical composition containing a therapeutically effective amount of the CKLF1 C-terminal polypeptide and pharmaceutically acceptable salts, carrier or excipient. Further disclosed are the polynucleotides encoding the C-terminal polypeptides of CKLF1, and vectors and host cells containing the polynucleotides; the in vitro assays for detecting the expression level of the polypeptide or polynucleotide in a test sample; and the monoclonal or polyclonal antibodies against the polypeptides or active fragments thereof. The polypeptides of the present invention can be pharmaceutically used for treating the HIV infection, allergic disease, allograft rejection, diseases in brain and autoimmune diseases.

摘要翻译： 公开了具有SEQ ID NO：2的氨基酸序列并且具有SEQ ID NO：2的氨基酸残基9至27的多肽，它们共同命名为CKLF1的C末端多肽。 还公开了含有治疗有效量的CKLF1 C末端多肽和药学上可接受的盐，载体或赋形剂的药物组合物。 还公开了编码CKLF1的C末端多肽的多核苷酸，以及含有多核苷酸的载体和宿主细胞; 用于检测测试样品中多肽或多核苷酸的表达水平的体外测定; 以及针对多肽或其活性片段的单克隆或多克隆抗体。 本发明的多肽可以用于治疗HIV感染，过敏性疾病，同种异体移植排斥，脑部疾病和自身免疫性疾病。

公开(公告)号：US20070194286A1

公开(公告)日：2007-08-23

申请号：US11356790

申请日：2006-02-17

申请人： Richard Kaner ,  Dan Li ,  Jiaxing Huang

发明人： Richard Kaner ,  Dan Li ,  Jiaxing Huang

IPC分类号： H01B1/12

CPC分类号： C08G73/0266 ,  D01D5/38 ,  D01D5/40 ,  D01F6/76

摘要： A new method for forming stable polyaniline nanofiber colloids uses electrostatic repulsion to maintain dispersion of the nanofibers and prevent aggregation during synthesis of the nanofibers. The colloidal suspensions are formed directly from the reactants in solution maintained at a pH of about 1.0 to about 4.0 and a temperature of about 10° C. to about 100° C. with minimal or no stirring. Also set forth are new methods for forming ultrathin films of polyaniline nanofibers via self-assembly.

摘要翻译： 用于形成稳定的聚苯胺纳米纤维胶体的新方法使用静电排斥来保持纳米纤维的分散并防止在纳米纤维合成期间的聚集。 胶体悬浮液直接由溶液中的反应物形成，保持在约1.0至约4.0的pH和约10℃至约100℃的温度，同时最小或不搅拌。 还阐述了通过自组装形成聚苯胺纳米纤维超薄膜的新方法。

公开(公告)号：US20070149890A1

公开(公告)日：2007-06-28

申请号：US11316332

申请日：2005-12-22

申请人： Dan Li ,  Shelley Cazares ,  Jaeho Kim ,  Kent Lee

发明人： Dan Li ,  Shelley Cazares ,  Jaeho Kim ,  Kent Lee

IPC分类号： A61B5/04

CPC分类号： A61B5/0464 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571 ,  A61N1/36578 ,  A61N1/36585 ,  A61N1/3925 ,  A61N1/3962

摘要： A tachyarrhythmia detection and classification system classifies tachyarrhythmias based on an analysis of morphological features of a cardiac signal enhanced by using one or more physiological parameters indicative of hemodynamic stability and/or activity level. The tachyarrhythmia detection and classification system computes a measure of similarity between an arrhythmic waveform of the cardiac signal a template waveform for that cardiac signal, such as a correlation coefficient representative of the correlation between morphological features of the arrhythmic waveform and morphological features of the template waveform. A detected tachyarrhythmia episode is classified by comparing the measure of similarity to a threshold that is dynamically adjusted using the one or more physiological parameters.

摘要翻译： 快速心律失常检测和分类系统基于通过使用指示血液动力学稳定性和/或活动水平的一个或多个生理参数来增强的心脏信号的形态学特征的分析来分类快速性心律失常。 快速心律失常检测和分类系统计算心脏信号的心律失常波形与该心脏信号的模板波形之间的相似性的度量，例如表示心律失常波形的形态特征与模板波形的形态特征之间的相关性的相关系数 。 通过将相似性测量值与使用一个或多个生理参数动态调整的阈值进行比较来分类检测到的快速性心律失常发作。

公开(公告)号：US07169857B2

公开(公告)日：2007-01-30

申请号：US10677746

申请日：2003-10-03

申请人： Mark A. McHugh ,  Dan Li ,  Michael Oka

发明人： Mark A. McHugh ,  Dan Li ,  Michael Oka

IPC分类号： C08C19/18

CPC分类号： C08J9/122 ,  C08F14/18 ,  C08J2201/032 ,  C08J2203/08 ,  C08J2327/12 ,  Y02P20/544

摘要： Fluoroelastomers are combined with chemical agents in the presence of supercritical carbon dioxide by swelling the fluoroelastomer with the carbon dioxide, and impregnating the swollen fluorelastomer with the chemical agent. The process can be conducted at relatively low temperatures and pressures such that degradation of the fluoroelastomer or the chemical agent is avoided. The chemical agent is preferably a curing agent which includes functional groups that interact with functional groups on the fluoroelastomer to create an association therebetween. The process is enhanced by pre-dissolving the chemical agent in a solvent which does not solubilize the fluoroelastomer to a great extent, but which is itself soluble in supercritical carbon dioxide. In addition, during combining, mechanical mastication is performed to create a free flowing powder.

摘要翻译： 在超临界二氧化碳的存在下，通过用二氧化碳溶胀含氟弹性体，并用化学试剂浸渍溶胀的荧光体，氟化弹性体与化学试剂结合。 该方法可以在相对较低的温度和压力下进行，从而避免含氟弹性体或化学试剂的降解。 化学剂优选是固化剂，其包括与氟弹性体上的官能团相互作用以在它们之间形成缔合的官能团。 通过将化学试剂预溶解在很大程度上不溶解含氟弹性体但是本身可溶于超临界二氧化碳的溶剂中来增强该方法。 此外，在组合期间，进行机械咀嚼以产生自由流动的粉末。

公开(公告)号：US20060281999A1

公开(公告)日：2006-12-14

申请号：US11151102

申请日：2005-06-13

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61B5/04

CPC分类号： G06K9/00523 ,  A61B5/04525 ,  A61B5/0464 ,  A61B5/7264

摘要： An implantable medical device includes an arrhythmia detection and classification system that classifies an arrhythmia episode based on an irregularity parameter and/or a complexity parameter. The arrhythmia episode is detected from a cardiac signal. The irregularity parameter is indicative of the degree of cycle length irregularity of the cardiac signal and the complexity parameter is indicative of the degree of morphological complexity of the cardiac signal. One example of the irregularity parameter is an irregularity sample entropy, or a parameter related to the irregularity sample entropy, computed to indicate the cycle length irregularity. One example of the complexity parameter is a complexity sample entropy, or a parameter related to the complexity sample entropy, computed to indicate the morphological complexity. In one embodiment, the detected arrhythmia episode is classified using both the irregularity parameter and the complexity parameter.

公开(公告)号：US20060233175A1

公开(公告)日：2006-10-19

申请号：US11393968

申请日：2006-03-30

申请人： Yi Ge ,  Dan Li ,  Zhiyong Liang ,  Yonghua Lin ,  Yan Wang

发明人： Yi Ge ,  Dan Li ,  Zhiyong Liang ,  Yonghua Lin ,  Yan Wang

IPC分类号： H04L12/56 ,  H04J3/16

CPC分类号： H04L45/70 ,  H04L45/04 ,  H04L45/52 ,  H04L2212/00

摘要： The present invention reduces the burden of the network having heavier load, maintains the load balance among different networks, and improves the overall resource utilization efficiency and transmission qualities of the networks, by providing a network forwarding apparatus for selectively distributing the IP packets to be forwarded to the network having less traffic for transmission by monitoring in real-time the traffic in the different networks.

公开(公告)号：US20050089591A1

公开(公告)日：2005-04-28

申请号：US10970017

申请日：2004-10-21

申请人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

发明人： Robert Gow ,  George Sypert ,  John Pierce ,  Dan Li ,  Xun Yan ,  Rodger Marentis

IPC分类号： A23F3/00 ,  A61K31/522 ,  A61K36/00 ,  A61K36/185 ,  A61K35/78

CPC分类号： A61K36/185

摘要： The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making maté compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native maté plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.

摘要翻译： 本发明包括用于制备衍生自具有降低的咖啡因和单宁浓度的Ilex种，特别是白僵菌的组合物的组合物的方法，通过这些方法制备的组合物，口服递送制剂和使用该组合物的方法。 特别地，本发明包括与天然植物材料相比制备具有预定特征的，例如降低量的咖啡因，升高的咖啡因量和/或降低量的单宁化合物的方法。 此外，本发明包括附加处理步骤的方法，tp产生具有预定生物碱比例或分布的组合物以满足最终产品的特定考虑。 本发明的组合物可以用于特定用途，例如片剂或其它口服递送载体。 这些组合物可用于治疗生理和医学状况的方法。

公开(公告)号：US20050075460A1

公开(公告)日：2005-04-07

申请号：US10677746

申请日：2003-10-03

申请人： Mark McHugh ,  Dan Li ,  Michael Oka

发明人： Mark McHugh ,  Dan Li ,  Michael Oka

IPC分类号： C08F14/18

CPC分类号： C08J9/122 ,  C08F14/18 ,  C08J2201/032 ,  C08J2203/08 ,  C08J2327/12 ,  Y02P20/544

摘要： Fluoroelastomers are combined with chemical agents in the presence of supercritical carbon dioxide by swelling the fluoroelastomer with the carbon dioxide, and impregnating the swollen fluorelastomer with the chemical agent. The process can be conducted at relatively low temperatures and pressures such that degradation of the fluoroelastomer or the chemical agent is avoided. The chemical agent is preferably a curing agent which includes functional groups that interact with functional groups on the fluoroelastomer to create an association therebetween. The process is enhanced by pre-dissolving the chemical agent in a solvent which does not solubilize the fluoroelastomer to a great extent, but which is itself soluble in supercritical carbon dioxide. In addition, during combining, mechanical mastication is performed to create a free flowing powder.

摘要翻译： 在超临界二氧化碳的存在下，通过用二氧化碳溶胀含氟弹性体，并用化学试剂浸渍溶胀的荧光体，氟化弹性体与化学试剂结合。 该方法可以在相对较低的温度和压力下进行，从而避免含氟弹性体或化学试剂的降解。 化学剂优选是固化剂，其包括与氟弹性体上的官能团相互作用以在它们之间形成缔合的官能团。 通过将化学试剂预溶解在很大程度上不溶解含氟弹性体但是本身可溶于超临界二氧化碳的溶剂中来增强该方法。 此外，在组合期间，进行机械咀嚼以产生自由流动的粉末。

公开(公告)号：US20050075436A1

公开(公告)日：2005-04-07

申请号：US10677735

申请日：2003-10-03

申请人： Mark McHugh ,  Dan Li

发明人： Mark McHugh ,  Dan Li

IPC分类号： C08F8/00 ,  C08J3/205 ,  C08L1/00

CPC分类号： C08J3/205 ,  C08F8/00 ,  C08F8/18 ,  C08F8/30 ,  C08F2800/20 ,  Y02P20/544 ,  C08F14/18 ,  C08F214/262 ,  C08F210/02

摘要： Elastomeric polymers are combined with chemical agents in the presence of supercritical fluids such as supercritical carbon dioxide by swelling the polymer with the supercritical fluid, and impregnating the swollen polymer with the chemical agent. The process can be conducted at relatively low temperatures and pressures such that degradation of the polymer or the chemical agent is avoided. The chemical agent is preferably a curing agent which includes functional groups that interact with functional groups on the polymer to create an association therebetween. The process is enhanced by pre-dissolving the chemical agent in a solvent which does not solubilize the polymer to a great extent, but which is itself soluble in the supercritical fluid. In addition, during combining, mechanical mastication is performed to create a free flowing powder.

摘要翻译： 在超临界流体如超临界二氧化碳的存在下，通过用超临界流体溶胀聚合物，并用化学试剂浸渍溶胀的聚合物，使弹性体聚合物与化学试剂结合。 该方法可以在相对低的温度和压力下进行，从而避免聚合物或化学试剂的降解。 化学剂优选是固化剂，其包括与聚合物上的官能团相互作用以在它们之间形成缔合的官能团。 通过将化学试剂预溶解在很大程度上不溶解聚合物但本身可溶于超临界流体的溶剂中来增强该方法。 此外，在组合期间，进行机械咀嚼以产生自由流动的粉末。