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公开(公告)号：US20100065733A1
公开(公告)日：2010-03-18
申请号：US12306162
申请日：2007-06-25
CPC分类号： H01J49/429 , G01N27/622 , H01J49/0031 , H01J49/004
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator (6) arranged upstream of a collision or fragmentation cell (8). Ions are separated according to their ion mobility within the ion mobility spectrometer or separator (6). The kinetic energy of the ions exiting the ion mobility spectrometer or separator (6) is increased substantially linearly with time in order to optimise the fragmentation energy of ions as they enter the collision or fragmentation cell (8). During the time that the potential of the ion mobility spectrometer or separator (6) is being varied, the potential of ion-optical components upstream of the ion mobility spectrometer or separator (6) such as an ion source (1), ion guide (2), quadrupole mass filter (3), optional second collision or fragmentation cell (4) and an ion trapping device (5) are kept constant.
摘要翻译： 公开了一种质谱仪，其包括设置在碰撞或分裂单元（8）的上游的离子迁移谱仪或分离器（6）。 根据离子迁移谱仪或分离器（6）内的离子迁移率分离离子。 离子离子迁移谱仪或分离器（6）离子的动能随着时间的推移基本线性地增加，以优化离子进入碰撞或破碎电池（8）时的碎裂能。 在离子迁移谱仪或分离器（6）的电位变化的时间内，离子迁移谱仪或分离器（6）上游离子光学部件的离子源（1），离子导向器 2），四极质量过滤器（3），任选的第二碰撞或碎裂单元（4）和离子捕获装置（5）保持恒定。
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公开(公告)号：US06791078B2
公开(公告)日：2004-09-14
申请号：US10603824
申请日：2003-06-26
IPC分类号： H01J4940
CPC分类号： G01N27/622
摘要： A mass spectrometer comprising an ion mobility separator for separating ions according to their ion mobility is disclosed. The ion mobility separator comprises a plurality of electrodes and one or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain ion mobility are separated from other ions having different ion mobilities.
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93.发明授权Mass spectrometer with corrugations, wells, or barriers and a driving DC voltage or potential 有权具有波纹，孔或障碍物和驱动直流电压或电位的质谱仪公开(公告)号：US09184039B2
公开(公告)日：2015-11-10
申请号：US12092313
申请日：2006-11-01
CPC分类号： H01J49/062 , H01J49/004 , H01J49/4235 , H01J49/427
摘要： A mass analyzer (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of seudo-potential corrugations are created along the axis of the mass analyzer (2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyzer (2) in order to urge ions along the length of the mass analyzer (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyzer (2) in reverse order of mass to charge ratio.
摘要翻译： 提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。 沿着质量分析器（2）的轴线产生多个潜在的波纹。 伪电位波纹的振幅或深度与离子的质荷比成反比。 为了沿着质量分析器（2）的长度推动离子，一个或多个瞬态直流电压被施加到质量分析器（2）的电极。 施加到电极的瞬态直流电压的幅度随着时间而增加，并且使质子分析器（2）以与质荷比相反的顺序发射离子。
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94.发明授权Segmented planar calibration for correction of errors in time of flight mass spectrometers 有权分段平面校准用于校正飞行时间质谱仪中的误差公开(公告)号：US08872104B2
公开(公告)日：2014-10-28
申请号：US14117756
申请日：2012-05-16
CPC分类号： H01J49/0036 , H01J49/0009 , H01J49/02 , H01J49/025 , H01J49/40 , H01J49/401
摘要： An ion detector system for a mass spectrometer is disclosed comprising an ion detector comprising an array of detector elements. The ion detector system is arranged to correct for tilt and non-linear aberrations in an isochronous plane of ions. The ion detector system generates separate first mass spectral data sets for each detector element and then applies a calibration coefficient to each of the first mass spectral data sets to produce a plurality of second calibrated mass spectral data sets. The plurality of second calibrated mass spectral data sets are then combined to form a composite mass spectral data set.
摘要翻译： 公开了一种用于质谱仪的离子检测器系统，其包括具有检测器元件阵列的离子检测器。 离子检测器系统被布置成校正离子的等时平面中的倾斜和非线性像差。 离子检测器系统为每个检测器元件生成单独的第一质谱数据集，然后将校准系数应用于每个第一质谱数据集以产生多个第二校准质谱数据集。 然后将多个第二校准质谱数据组合以形成复合质谱数据集。
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公开(公告)号：US08481921B2
公开(公告)日：2013-07-09
申请号：US12676154
申请日：2008-09-03
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/025 , H01J49/26 , H01J49/4265 , H01J49/427
摘要： A mass spectrometer is disclosed comprising a first storage ion trap arranged upstream of a high performance analytical ion trap. According to an embodiment ions are simultaneously scanned from both the first and second ion trap. At any instant in time the quantity of charge present within the second ion trap is limited or restricted so that the second ion trap does not suffer from space charge saturation effects and hence the performance of the second ion trap is not degraded.
摘要翻译： 公开了一种质谱仪，其包括布置在高性能分析离子阱的上游的第一存储离子阱。 根据一个实施例，离子同时从第一和第二离子阱两者扫描。 在任何时刻，存在于第二离子阱内的电荷量被限制或限制，使得第二离子阱不会受到空间电荷饱和效应的影响，因此第二离子阱的性能不会降低。
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公开(公告)号：US20120208289A1
公开(公告)日：2012-08-16
申请号：US13453657
申请日：2012-04-23
IPC分类号： G01N27/62
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译： 公开了一种质谱仪，其包括电子转移解离单元。 当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。 电池包括形成球形捕获体积的多个环形电极。 在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。 从而提供具有增强的灵敏度的电子转移解离电池。 在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。
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公开(公告)号：US08063358B2
公开(公告)日：2011-11-22
申请号：US11916430
申请日：2006-06-01
IPC分类号： H01J49/26
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analyzed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译： 公开了一种质谱法，其中分析了来自离子检测器的电压信号。 获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。 然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。 然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。 然后将各种时间和强度数据对被整合以产生平滑的连续质谱。 然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。 可以确定在连续质谱中观察到的质量峰的开始和结束时间。 然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。 然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。
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公开(公告)号：US20100108879A1
公开(公告)日：2010-05-06
申请号：US12514972
申请日：2007-11-15
IPC分类号： H01J49/26
CPC分类号： H01J49/4215 , G01N27/622 , H01J49/004 , H01J49/426
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer (8) and an ion gate (9). A collision cell (10) is arranged downstream of the ion gate (9). The operation of the ion mobility spectrometer (8) and the ion gate (9) are synchronised so that only ions having a particular mass to charge ratio and a desired charge state are onwardly transmitted to the collision cell (10).
摘要翻译： 公开了一种质谱仪，其包括离子迁移谱仪（8）和离子门（9）。 碰撞室（10）布置在离子门（9）的下游。 离子迁移谱仪（8）和离子浇口（9）的操作是同步的，使得只有具有特定质荷比的离子和期望的电荷状态向上传输到碰撞池（10）。
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公开(公告)号：US20100084547A1
公开(公告)日：2010-04-08
申请号：US12524378
申请日：2008-01-25
CPC分类号： H01J49/428
摘要： A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals (13, 14, 15) having a plurality of frequency notches (16a; 16b; 16c) are applied sequentially to the rods of the quadrupole rod set. The notched broadband frequency signals (16a, 16b, 16c) cause undesired ions to be resonantly or parametrically ejected from the ion guide. The resulting ion signals are deconvoluted to provide a mass spectrum.
摘要翻译： 公开了一种质谱仪，其包括四极棒离子导向器或质量过滤器装置。 具有多个频率切口（16a; 16b; 16c）的宽带频率信号（13,14,15）被依次施加到四极杆组的杆上。 缺口宽带频率信号（16a，16b，16c）使离子引导不需要的离子共振或参数地喷出。 所得到的离子信号被去卷积以提供质谱。
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公开(公告)号：US07635841B2
公开(公告)日：2009-12-22
申请号：US10498046
申请日：2002-12-12
IPC分类号： H01J49/00
CPC分类号： H01J49/062 , Y10T436/24
摘要： A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P×T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.
摘要翻译： 公开了一种质谱法，其中在产品PxT至少为1毫巴的压力下，在保持在压力P的AC或RF离子导向器内捕获离子一段时间T。 捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的 质量分析。
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