公开(公告)号：US20240325144A1

公开(公告)日：2024-10-03

申请号：US18742979

申请日：2024-06-13

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Stephen C. Geist ,  Robert C. Taft ,  Travis Zenyo Oba ,  Sam Sok ,  Matthew A. Peterson ,  Kevin M. Golemo ,  Mark Chau ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61B6/00 ,  A61B8/12

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2/2466 ,  A61B6/4441 ,  A61B8/12 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/005 ,  A61F2230/0054 ,  A61F2230/0078 ,  A61F2250/0018 ,  A61F2250/0029 ,  A61F2250/0069

Abstract: A prosthetic heart valve for implantation within a native atrioventricular heart valve. The prosthetic heart valve includes a self-expanding frame having an annular main body and a valve member disposed within the main body. The prosthetic heart valve includes an atrial sealing member formed by a fabric cover and a plurality of arms that are arranged side-by-side in a circumferential direction around the main body. The atrial sealing member extends radially outwardly from the main body and a peripheral portion of the atrial sealing member curves upwardly for conforming to surrounding native anatomy. The prosthetic heart valve further includes one or more ventricular anchors extending from the main body for capturing native leaflet tissue and thereby securing the prosthetic heart valve within the native atrioventricular heart valve.

公开(公告)号：US20240315835A1

公开(公告)日：2024-09-26

申请号：US18731039

申请日：2024-05-31

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Travis Zenyo Oba ,  Matthew A. Peterson ,  Glen T. Rabito ,  Alexander H. Cooper ,  David Robert Landon ,  Jeremy Brent (aka J. Brent) Ratz ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61L27/04 ,  A61L27/36

CPC classification number: A61F2/2409 ,  A61F2/2418 ,  A61L27/04 ,  A61L27/3625 ,  A61F2/2412 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2230/0093 ,  A61F2250/0018 ,  A61F2250/0039 ,  A61F2250/0063 ,  A61L2430/20

Abstract: A self-expanding prosthetic heart valve includes an inner frame and an outer sealing frame. A lower region of the outer sealing frame is coupled to a lower region of the inner frame. At least a portion of the outer frame has a D-shape cross-section for conforming to a shape of a native heart valve annulus. Elongate anchors are positioned outwardly from the outer sealing frame for anchoring to native leaflets. Preferably, the native leaflets are secured between the anchors and an outer surface of the outer sealing frame. A valve body is positioned within an interior lumen of the inner frame and provides a one-way valve mechanism for replacing the function of the native leaflets. For additional stability, a further anchoring mechanism may extend from the inner frame for attachment to a heart wall. The prosthetic heart valve is well-suited for replacing the function of a native tricuspid valve.

公开(公告)号：US20240081986A1

公开(公告)日：2024-03-14

申请号：US18510534

申请日：2023-11-15

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Travis Zenyo Oba ,  Seung-Beom Yi ,  Lauren R. Freschauf ,  Juan Valencia

IPC: A61F2/24 ,  A61B17/00

CPC classification number: A61F2/2418 ,  A61B17/00234 ,  A61F2/2433 ,  A61F2/2436 ,  A61B2017/00243 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0065 ,  A61F2250/0059 ,  A61F2250/0063 ,  A61F2250/0069

Abstract: A prosthetic heart valve includes an outer frame, a cover, an inner frame, and a valve structure. The outer frame includes a main body and an atrial flange. The main body includes a plurality of struts forming a plurality of circumferential rows of cells, a plurality of rows of barbs extending from junctions of the struts, the atrial flange extending radially outwardly and in an atrial direction from the inflow end of the main body. The atrial flange includes an oval shape corresponding to a shape of the patient's native mitral valve anatomy. The cover is disposed on a radially inner side of the atrial flange and on a radially outer side of the atrial flange. The inner frame is disposed within the outer frame and has a cylindrical shape. The valve structure is coupled to the inner frame and includes a plurality of leaflets.

公开(公告)号：US11911264B2

公开(公告)日：2024-02-27

申请号：US17017629

申请日：2020-09-10

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Marlowe E. Patterson ,  Seung-Beom Yi ,  Stephen C. Geist ,  Travis Zenyo Oba

IPC: A61F2/24

CPC classification number: A61F2/2412 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2427 ,  A61F2/2445 ,  A61F2/246 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0069 ,  A61F2250/006 ,  A61F2250/0063

Abstract: A prosthetic spacer assembly includes a spacer body, a first anchor, and a second anchor. The first anchor and the second anchor are each connected to the spacer body. The first anchor is configured to capture a first native valve leaflet between the first anchor and the spacer body. The second anchor is configured to capture a second native valve leaflet between the second anchor and the spacer body. When inside a delivery sheath, the first anchor and the second anchor can extend distally from the spacer body.

公开(公告)号：US11850147B2

公开(公告)日：2023-12-26

申请号：US16597460

申请日：2019-10-09

Applicant: Edwards Lifesciences Corporation

Inventor： Travis Zenyo Oba ,  Seung-Beom Yi ,  Lauren R. Freschauf ,  Juan Valencia

IPC: A61F2/24 ,  A61B17/00

CPC classification number: A61F2/2418 ,  A61B17/00234 ,  A61F2/2433 ,  A61F2/2436 ,  A61B2017/00243 ,  A61F2210/0014 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/0065 ,  A61F2250/0059 ,  A61F2250/0063 ,  A61F2250/0069

Abstract: A prosthetic valve assembly includes a support structure and a valve component. The support structure includes a first frame and a sealing member. The first frame includes a lumen extending between inflow and outflow ends. The sealing member extends inwardly into the lumen of the first frame and includes a first end wall defining a first orifice, a second end wall axially spaced from the first end wall and defining a second orifice, and an inner sleeve extending axially from the first end wall to the second end wall and spaced radially inwardly from the first frame. The valve component includes a second frame and a valve structure supported inside of the second frame for permitting blood flow through the valve component in one direction and blocking blood flow in the opposite direction. The valve component is configured to expand within and engage the inner sleeve of the sealing member.

公开(公告)号：US20230277316A1

公开(公告)日：2023-09-07

申请号：US18196375

申请日：2023-05-11

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Harish Manickam Srinimukesh ,  Travis Zenyo Oba ,  David Robert Landon ,  Glen T. Rabito

IPC: A61F2/24

CPC classification number: A61F2/2439 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2250/0098

Abstract: Disclosed herein are embodiments of a delivery system which can be used to recapture and/or reposition a replacement valve, such as a replacement mitral valve, after initial deployment of the valve. Embodiments of the delivery system can involve a torqueing manifold that interacts with multiple tethers that are releasably coupled to eyelets of a replacement heart valve. Engagement pins may be configured to releasably retain one end of the tethers.

公开(公告)号：US11684474B2

公开(公告)日：2023-06-27

申请号：US16934879

申请日：2020-07-21

Applicant: Edwards Lifesciences Corporation

Inventor： Harish Manickam Srinimukesh ,  Travis Zenyo Oba ,  David Robert Landon ,  Glen T. Rabito

IPC: A61F2/24

CPC classification number: A61F2/2439 ,  A61F2/2436 ,  A61F2220/0008 ,  A61F2250/0098

Abstract: Disclosed herein are embodiments of a delivery system which can be used to recapture and/or reposition a replacement valve, such as a replacement mitral valve, after initial deployment of the valve. Embodiments of the disclosure can use the crimping/tensioning of sutures in order to re-crimp the replacement valve after release, though longitudinal or rotational forces.

公开(公告)号：US20230142064A1

公开(公告)日：2023-05-11

申请号：US17993563

申请日：2022-11-23

Applicant: Edwards Lifesciences Corporation

Inventor： Mark Chau ,  Sam Shafigh ,  Travis Zenyo Oba

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2436 ,  A61F2220/0016

Abstract: An implant includes an interface and a wing that is coupled to the interface. A catheter is transluminally advanceable to a heart chamber upstream of a heart valve of a subject and houses the implant. A delivery tool comprises a shaft and a driver. Via engagement with the interface, the shaft is configured to (i) deploy the implant out of the catheter such that, within the chamber, the wing extends away from the interface; and (ii) position the implant in a position in which the interface is at a site in the heart and the wing extends over a first leaflet of the valve toward an opposing leaflet of the valve. The driver is configured to secure the implant in the position by driving an anchor through the interface and into tissue at the site. Other embodiments are also described.

公开(公告)号：US20230046495A1

公开(公告)日：2023-02-16

申请号：US17980384

申请日：2022-11-03

Applicant: Edwards Lifesciences Corporation

Inventor： Travis Zenyo Oba ,  Matthew A. Peterson ,  Glen T. Rabito ,  Alexander H. Cooper ,  David Robert Landon ,  J. Brent Ratz ,  Seung-Beom Yi

IPC: A61F2/24 ,  A61L27/36 ,  A61L27/04

Abstract: A replacement mitral valve prosthesis includes a support structure and a valve body having three flexible leaflets. The support structure preferably includes an internal valve frame and an external sealing frame. The valve frame supports the flexible leaflets. The sealing frame is adapted to conform to the shape of the native mitral valve annulus. The sealing frame may be coupled to an inlet end of the valve frame, an outlet end of the valve frame, or both. A plurality of anchors is coupled to the outlet end of the valve frame. The anchors extend radially outwardly for placement behind native leaflets. The prosthesis preferably includes a skirt disposed along an exterior of the external sealing frame. The prosthesis is collapsible for delivery into the heart via a delivery catheter. The prosthesis is configured to self-expand for deployment in the heart when released from the delivery catheter.

公开(公告)号：US11224507B2

公开(公告)日：2022-01-18

申请号：US16506886

申请日：2019-07-09

Applicant: Edwards Lifesciences Corporation

Inventor： Matthew A. Peterson ,  Seung-Beom Yi ,  Siddharth Vad ,  Travis Zenyo Oba ,  Lauren R. Freschauf ,  Amanda French ,  Yaron Keidar ,  Yuanlong Du ,  Gregory Bak-Boychuk ,  Kevin M. Golemo ,  Alexander H. Cooper

IPC: A61F2/24

Abstract: A heart valve prosthesis for replacing a native mitral valve includes a self-expanding frame with a plurality of anchoring members disposed along the lower region. A valve body is positioned within the self-expanding frame and includes a plurality of leaflets configured to allow blood flow through the self-expanding frame in only one direction. A skirt surrounds the self-expanding frame and is spaced apart therefrom for contacting surrounding tissue and impeding blood flow around the self-expanding frame. The skirt may be reinforced with wires to help maintain a desired shape. The leaflets in the valve body are preferably connected to the self-expanding frame through one or more intermediate components such that the valve body is spaced radially inwardly from an inner surface of the self-expanding frame.