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公开(公告)号：US09458450B2
公开(公告)日：2016-10-04
申请号：US14026413
申请日：2013-09-13
CPC分类号： C12N13/00 , B01D17/044 , B01D21/28 , B01D21/283 , B06B1/0644 , C12M47/02 , H01L41/053 , H01L41/0913 , H01L41/1876
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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公开(公告)号：US09457302B2
公开(公告)日：2016-10-04
申请号：US14708035
申请日：2015-05-08
发明人： Bart Lipkens , Jason Dionne
IPC分类号： B01D43/00 , H01L41/053 , B06B1/06 , C12M1/00
CPC分类号： B01D43/00 , B01D21/283 , B06B1/06 , B06B1/0625 , C12M47/02 , H01L41/0533
摘要： An apparatus for separating particles from a fluid stream includes a flow chamber that has at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber. The transducer includes a piezoelectric array with at least two piezoelectric elements. The piezoelectric array includes a piezoelectric material to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer.
摘要翻译： 用于从流体流分离颗粒的装置包括具有至少一个入口和至少一个出口的流动室。 至少一个超声换能器位于流动室的壁上。 换能器包括具有至少两个压电元件的压电阵列。 压电阵列包括在流动室中产生多维声驻波的压电材料。 反射器位于流动室的与至少一个超声换能器相反的一侧的壁上。
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公开(公告)号：US20160237110A1
公开(公告)日：2016-08-18
申请号：US15044309
申请日：2016-02-16
发明人： Rudolf Gilmanshin , Bart Lipkens
CPC分类号： C07K1/045 , B01L3/502761 , B01L2200/0668 , B01L2300/0816 , B01L2300/12 , B01L2400/0436 , C07K16/00 , C12P19/34 , G01N1/31 , G01N15/1459 , G01N33/54313 , G01N2001/4094 , G01N2015/1006
摘要： Described herein are microreactors and methods of modifying support particles using acoustic standing waves. A liquid medium containing suspended support particles is flowed along a flow path through a channel, and an acoustic standing wave is applied to the channel to hold the suspended particles at a point in the channel. The held particles are then subjected to one or more reactions by flowing biochemical reactants through the channel. Unbound biological reactant is optionally washed from the channel. The reacted support particles can be released from the acoustic standing wave for further processing using, for example, flow cytometry or fluorescence microscopy.
摘要翻译： 本文描述的是微反应器和使用声驻波来改性载体颗粒的方法。 含有悬浮载体颗粒的液体介质沿着流路通过通道流动，并且声波驻波被施加到通道以将悬浮颗粒保持在通道中的某一点。 然后通过使生物化学反应物流过通道，将保持的颗粒进行一次或多次反应。 任选地从通道洗涤未结合的生物反应物。 反应的载体颗粒可以使用例如流式细胞术或荧光显微镜从声驻波中释放以进一步处理。
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公开(公告)号：US09340435B2
公开(公告)日：2016-05-17
申请号：US14711627
申请日：2015-05-13
发明人： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, Jr. , Thomas J. Kennedy, III , Louis Masi
IPC分类号： C02F1/36 , B01D17/04 , B01D17/12 , C02F1/40 , B01D43/00 , C02F103/10 , C02F103/00 , B06B1/06
CPC分类号： C02F1/36 , B01D17/045 , B01D17/12 , B01D21/283 , B01D43/00 , B06B1/0644 , C02F1/40 , C02F2103/007 , C02F2103/10
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
摘要翻译： 使用声驻波在具有声流装置的流体流动方案中将组分与多组分流体（例如来自油 - 水混合物的油）分离。 例如，流动方案和装置允许在油聚结，聚集并且变得比水更浮力时捕获油。
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公开(公告)号：US20160089620A1
公开(公告)日：2016-03-31
申请号：US14870952
申请日：2015-09-30
发明人： Bart Lipkens , Jeff King , David Sokolowski , Anthony B. Masi , Brian T. Kennedy , Brian McCarthy , Benjamin Ross-Johnsrud , Jason Dionne , Dane Mealey , Jason Barnes
CPC分类号： B01D21/283 , B01D17/044 , B01D17/06 , B01D19/0078 , B06B1/06 , B06B1/0622 , B06B1/0644 , B06B2201/71 , C12M47/04 , C12N13/00
摘要： Acoustophoretic devices for separating particles from a non-flowing host fluid are disclosed. The devices include a substantially acoustically transparent container and a separation unit, with the container being placed within the separation unit. An ultrasonic transducer in the separation unit creates a planar or multi-dimensional acoustic standing wave within the container, trapping particles disposed within the non-flowing fluid and causing them to coalesce or agglomerate, then separate due to buoyancy or gravity forces.
摘要翻译： 公开了用于从非流动主流体分离颗粒的声学装置。 这些装置包括基本上声透明的容器和分离单元，容器被放置在分离单元内。 分离单元中的超声波换能器在容器内产生平面或多维声驻波，捕获设置在非流动流体内的颗粒，并使其聚结或附聚，然后由于浮力或重力而分离。
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96.发明授权公开(公告)号：US09228183B2
公开(公告)日：2016-01-05
申请号：US14557040
申请日：2014-12-01
CPC分类号： C12N13/00 , B01D17/044 , B01D21/28 , B01D21/283 , B06B1/0644 , C12M47/02 , H01L41/053 , H01L41/0913 , H01L41/1876
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
摘要翻译： 描述了通过操纵超声换能器的频率来改善捕获力的方法，其具有改善的吸引力的捕集力。 换能器包括陶瓷晶体。 晶体可能直接暴露于流体流动。 晶体可能是空气支撑的，导致更高的Q因子。
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公开(公告)号：US20140319077A1
公开(公告)日：2014-10-30
申请号：US14262569
申请日：2014-04-25
发明人： Bart Lipkens , Ari Mercado , Arthur Martin , Louis Masi , Jason Dionne
IPC分类号： B01D21/00
CPC分类号： B01D21/00 , B01D11/0223 , B01D11/0265 , B01D21/283 , B01D2221/10 , G01N33/15
摘要： Active pharmaceutical ingredients can be separated from their excipients by dissolving a pharmaceutical product (e.g. tablet, pill) into a solvent, then running the solution through an acoustophoretic device. Standing waves are used to separate the excipient from the active ingredient dissolved in the solvent.
摘要翻译： 活性药物成分可以通过将药物产品（例如片剂，丸剂）溶解在溶剂中，然后使溶液通过声学渗透装置来从其赋形剂中分离出来。 使用驻波将赋形剂与溶解在溶剂中的活性成分分离。
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公开(公告)号：US20130302213A1
公开(公告)日：2013-11-14
申请号：US13943529
申请日：2013-07-16
发明人： Bart Lipkens , Jason Dionne , Ari Mercado , Brian Dutra , Walter M. Presz, JR. , Thomas J. Kennedy, III , Louis Masi
IPC分类号： B01D43/00
CPC分类号： B01D17/04 , B01D43/00 , B06B1/0644 , C12M47/02
摘要： An acoustic standing wave is utilized to separate components from a multi-component fluid, such as oil from an oil-water mixture, in a fluid flow scheme with an acoustophoresis device. For example, the flow scheme and device allows for trapping of the oil as the oil coalesces, agglomerates, and becomes more buoyant than the water.
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公开(公告)号：US20130277317A1
公开(公告)日：2013-10-24
申请号：US13866943
申请日：2013-04-19
发明人： Nicholas M. LoRicco , Bart Lipkens
CPC分类号： C02F1/36 , B01D21/283 , H04R23/00
摘要： A system for enhancing the separation of particles or fluids from water is disclosed. A settling tank or skim tank is provided with an open submersible acoustophoretic separator. In a skim tank, the separator captures and holds oil droplets or particles, permitting them to coalesce until they are large enough and have sufficient buoyant force to float to the top of the tank. In a settling or sediment tank, separator captures and holds particles until they are large enough that the force of gravity causes them to settle out of the water. The acoustophoretic device thus speeds up separation of the particles or droplets from the water.
摘要翻译： 公开了一种用于增强颗粒或流体与水分离的系统。 一个沉淀槽或脱脂罐配有一个开放的潜水声波分离器。 在脱脂罐中，分离器捕获并保持油滴或颗粒，允许它们聚结，直到它们足够大并且具有足够的浮力来浮动到罐的顶部。 在沉淀池或沉淀池中，分离器捕获并保持颗粒，直到它们足够大，使得重力使其沉淀出水。 因此，声学装置加速颗粒或液滴与水的分离。
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公开(公告)号：US20130277316A1
公开(公告)日：2013-10-24
申请号：US13866584
申请日：2013-04-19
发明人： Brian Dutra , Bart Lipkens
IPC分类号： A61M1/36
CPC分类号： A61M1/3681 , A61M1/363 , A61M1/3678 , A61M2202/08 , B01D21/283
摘要： A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.
摘要翻译： 公开了一种在体外循环手术期间从血液中除去脂质的系统。 该系统使用具有改进的捕获力的声波分离器。 声波分离器的换能器包括陶瓷晶体。 血液流过分离器，脂质被捕获并除去。
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