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公开(公告)号：US08399651B2
公开(公告)日：2013-03-19
申请号：US13607990
申请日：2012-09-10
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 (Spy0416) which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体（Spy0416）不能切割IL-8和类似的底物，但仍保持对化脓性链球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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公开(公告)号：US08394390B2
公开(公告)日：2013-03-12
申请号：US13405162
申请日：2012-02-24
申请人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
发明人： Cesira Galeotti , Guido Grandi , Vega Masignani , Mariarosa Mora , Mariagrazia Pizza , Rino Rappuoli , Guilio Ratti , Vincenzo Scarlato , Maria Scarselli
IPC分类号： A61K39/095 , A61K39/02 , A61K39/38 , A61K38/00 , C07K1/00
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
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公开(公告)号：US08287885B2
公开(公告)日：2012-10-16
申请号：US12676192
申请日：2008-09-12
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体不能切割IL-8和类似的底物，但仍然保持对化脓性葡萄球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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公开(公告)号：US20120148616A1
公开(公告)日：2012-06-14
申请号：US13359442
申请日：2012-01-26
申请人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人： Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号： A61K39/095 , C07K14/22 , A61P37/04 , C07K7/08
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要： The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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公开(公告)号：US08147849B2
公开(公告)日：2012-04-03
申请号：US12706387
申请日：2010-02-16
IPC分类号： A61K39/09 , C12P21/06 , C07K14/315 , C12N15/09
CPC分类号： C07K14/315 , A61K39/00
摘要： The invention provides protective antigens for Group B streptococcus hypervirulent strains. The fragments are useful in vaccine compositions to induce protection against S. agalactiae, particularly against hypervirulent strains.
摘要翻译： 本发明提供了B组链球菌高毒力菌株的保护性抗原。 这些片段可用于疫苗组合物中，以诱导针对无精子症的保护，特别是针对高毒力菌株。
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公开(公告)号：US20120066779A1
公开(公告)日：2012-03-15
申请号：US13167887
申请日：2011-06-24
申请人： Sergio Abrignani , Guido Grandi
发明人： Sergio Abrignani , Guido Grandi
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： C07K14/70596 , A01K2217/05 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for such purposes.
摘要翻译： 本发明涉及CD81蛋白和多核酸在丙型肝炎的治疗和诊断中的应用以及用于此目的的药物组合物，动物模型和诊断试剂盒。
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公开(公告)号：US08025890B2
公开(公告)日：2011-09-27
申请号：US11434184
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译： 本发明提供了来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号：US07955604B2
公开(公告)日：2011-06-07
申请号：US11434127
申请日：2006-05-16
申请人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人： John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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99.发明申请IMMUNOGENIC COMPOSITIONS FOR GRAM POSITIVE BACTERIA SUCH AS STREPTOCOCCUS AGALACTIAE 失效AM AM E E E E E E E E E E E E E E E E E E E E E E E公开(公告)号：US20110110982A1
公开(公告)日：2011-05-12
申请号：US12906510
申请日：2010-10-18
申请人： John Telford , Guido Grandi , Immaculada Margarit Y. Ros , Cira Daniela Rinaudo , Domenico Maione
发明人： John Telford , Guido Grandi , Immaculada Margarit Y. Ros , Cira Daniela Rinaudo , Domenico Maione
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/05 , A61K39/08 , A61K39/085 , A61K39/09 , A61K39/095 , A61K2039/523 , C07K16/1267 , Y02A50/396
摘要： The invention relates to the identification of a new adhesin islands within the genomes of several Group A and Group B Streptococcus serotypes and isolates. The adhesin islands are thought to encode surface proteins which are important in the bacteria's virulence. Thus, the adhesin island proteins of the invention may be used in immunogenic compositions for prophylactic or therapeutic immunization against GAS or GBS infection. For example, the invention may include an immunogenic composition comprising one or more of the discovered adhesin island proteins.
摘要翻译： 本发明涉及鉴定几组A组和B组链球菌血清型和分离株的基因组中的新粘附素岛。 粘附素岛被认为编码在细菌的毒力中重要的表面蛋白质。 因此，本发明的粘附素岛蛋白可用于免疫原性组合物，用于针对GAS或GBS感染的预防性或治疗性免疫。 例如，本发明可以包括包含一种或多种所发现的粘附素岛蛋白的免疫原性组合物。
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公开(公告)号：US20110110967A1
公开(公告)日：2011-05-12
申请号：US12676192
申请日：2008-09-12
CPC分类号： C07K14/315 , A61K38/164 , A61K38/18 , A61K38/19 , A61K38/22 , A61K39/092 , A61K45/06 , A61K2039/522 , A61K2039/6037 , A61K2039/6043 , A61K2039/6068 , C07K14/22 , C07K14/235 , C07K14/285 , C07K14/33 , C07K14/475 , C07K14/52 , C07K14/575 , C07K16/1275 , C07K16/40 , C07K2319/00 , C07K2319/55 , Y02A50/466 , Y02A50/478 , Y10S530/825
摘要： The invention provides mutants of GAS57 which are unable to cleave IL-8 and similar substrates but which still maintain the ability to induce protection against S. pyogenes. The invention also provides antibodies which specifically bind to GAS57 and which inhibit its ability to cleave IL-8 and similar substrates. The mutants are useful, inter alia, in vaccine compositions to induce protection against S. pyogenes. The antibodies are useful, e.g., as therapeutics for treating S. pyogenes infections.
摘要翻译： 本发明提供的GAS57突变体不能切割IL-8和类似的底物，但仍然保持对化脓性葡萄球菌的保护的能力。 本发明还提供了特异性结合GAS57并且抑制其分裂IL-8和类似底物的能力的抗体。 突变体尤其可用于诱导保护成脓性葡萄球菌的疫苗组合物。 抗体是有用的，例如用作治疗化脓性链球菌感染的治疗剂。
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