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公开(公告)号：US09498557B2
公开(公告)日：2016-11-22
申请号：US12546231
申请日：2009-08-24
CPC分类号： A61L24/0005 , A61K47/60 , A61L24/0031 , A61L24/046 , A61L24/06 , A61L24/108 , C08H1/00 , C08L89/00 , C08L71/02 , C08L39/06
摘要： Some aspects of this disclosure relate to a method for forming a biomaterial in situ comprising: combining a solution of a crosslinker in a water soluble organic solvent with a precursor to covalently crosslink the precursor to form a crosslinked gel, with the crosslinker comprising a plurality of first functional groups and the precursor comprising a plurality of second functional groups, with the first functional groups chemically reacting with the second functional groups in situ to form covalent bonds and thereby form the crosslinked gel.
摘要翻译： 本公开的一些方面涉及原位形成生物材料的方法，包括：将水溶性有机溶剂中交联剂的溶液与前体结合，以共价交联前体以形成交联凝胶，交联剂包含多个 第一官能团和前体包含多个第二官能团，其中第一官能团与第二官能团原位化学反应形成共价键，从而形成交联凝胶。
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公开(公告)号：US08852230B2
公开(公告)日：2014-10-07
申请号：US12770573
申请日：2010-04-29
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00477 , A61B2017/00495 , A61B2017/0065 , A61B2017/00654 , A61B2017/22047 , A61F2/92 , A61F2210/0076 , A61L24/0015 , A61L24/0031 , A61L2400/04
摘要： Apparatus and methods for sealing a puncture through tissue or otherwise treating a body lumen of a patient. The carrier includes at least one, but not all, of the adherent layer components required to form a tacky or sticky adherent layer on the carrier. The remaining adherent layer precursor(s) are delivered to the carrier in situ to form a sticky and/or tacky adherent layer on the carrier that enhances the attachment and retention of the carrier to tissue surrounding a target treatment location in which the carrier is delivered. The carrier may include hydrogel and/or other porous material, e.g., for releasing one or more agents carried by the carrier at the treatment location.
摘要翻译： 用于密封通过组织穿刺或以其他方式治疗患者的体腔的装置和方法。 载体包括在载体上形成粘性或粘性粘合层所需的至少一种但不是全部的粘附层组分。 剩余的粘附层前体被原位递送到载体上，以在载体上形成粘性和/或粘性粘附层，其增强载体与载体递送的目标处理位置周围组织的连接和保持 。 载体可以包括水凝胶和/或其它多孔材料，例如用于在处理位置释放由载体携带的一种或多种试剂。
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93.发明授权Methods for sealing a vascular puncture using a plug including unreactive precursors 有权使用包括非活性前体的塞子密封血管穿刺的方法公开(公告)号：US08470362B2
公开(公告)日：2013-06-25
申请号：US12876980
申请日：2010-09-07
IPC分类号： A61L15/16
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00004 , A61B2017/00495 , A61B2017/00637 , A61B2017/0065 , A61B2017/00654 , A61K9/0024 , A61L26/0052 , A61L26/008 , A61L27/58 , A61L31/042 , A61L31/044 , A61L31/046 , A61L31/048 , A61L31/06 , A61L31/145 , A61L31/148 , A61L2300/232 , A61L2300/252 , A61L2300/418 , A61L2300/606 , A61L2400/04 , A61L2420/06 , C08L71/02
摘要： Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
摘要翻译： 提供了用于密封与血管连通的穿刺的方法，包括将由冻干的水凝胶或其它材料形成的多孔载体引入穿刺。 插塞可以在暴露于水性生理环境之前至少包括第一和第二水凝胶前体和由多孔载体承载的非调节状态的pH调节剂。 一旦暴露于体液，载体会随着冻干物质的水合而膨胀，以增强和促进穿刺的快速止血。 当塞子被置于穿刺中时，由体液（例如血液）引起的塞子的自然润湿使得第一和第二前体反应并交联成粘合剂或“粘性”水凝胶，其有助于保持塞子 穿刺的地方
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94.发明授权Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels 有权使用水凝胶制品的原位水合来密封或增加组织或血管的方法公开(公告)号：US08105622B2
公开(公告)日：2012-01-31
申请号：US11890929
申请日：2007-08-08
申请人： Amarpreet S. Sawhney
发明人： Amarpreet S. Sawhney
CPC分类号： A61L33/0064 , A61B17/12022 , A61B17/12099 , A61B17/12104 , A61B17/12109 , A61B17/12186 , A61B17/1219 , A61B2017/00898 , A61K6/0014 , A61K6/0067 , A61K9/0024 , A61K9/0036 , A61K9/0085 , A61K9/2027 , A61L24/0015 , A61L24/0031 , A61L31/145 , A61L31/16 , A61L2300/418 , A61K6/0035 , C08L39/06 , A61K6/0038 , C08L33/14 , C08L71/02
摘要： Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
摘要翻译： 将天然，重组或合成来源的药学上可接受的水凝胶聚合物或其混合物以干燥，较少水合或基本上脱水状态引入，并在生理环境中再水合以进行体积膨胀并影响密封，堵塞或增加 组织，组织缺陷或器官缺陷。 水凝胶聚合物可以通过在现场的控制释放递送治疗实体。 提供了从这种聚合物形成有用器件和植入器件的方法。
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公开(公告)号：US20100209478A1
公开(公告)日：2010-08-19
申请号：US12704692
申请日：2010-02-12
IPC分类号： A61F2/14 , A61K31/437 , A61K31/135 , A61P27/02 , A61P27/06 , B29B9/06
CPC分类号： A61K9/0051 , A61B17/12099 , A61B17/12159 , A61B17/1219 , A61F9/00772 , A61F2250/0067 , A61K31/135 , A61K31/437
摘要： An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
摘要翻译： 一个实施方案是用于阻断或减少穿过人眼的泪点或泪管的泪液的药物假体，并将药物递送到眼睛，所述药物包括脱水的共价交联的合成亲水性聚合物水凝胶，其尺寸通过泪点，脱水 水凝胶吸收生理水以横截面宽度膨胀至至少1mm，并且顺应地配合小孔，其中水凝胶包含分散在水凝胶中的治疗剂以释放至眼睛，水凝胶的水含量至少约为 当在生理盐水中体外充分水合时，其重量为50％或体积。
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公开(公告)号：US20090252781A1
公开(公告)日：2009-10-08
申请号：US12485192
申请日：2009-06-16
IPC分类号： A61F2/00 , A61K9/10 , A61K38/00 , A61K31/7088
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
摘要翻译： 本公开的一些方面涉及治疗影响患者眼睛的眼科疾病的方法，包括在眼周，眼内或玻璃体外部位置原位形成共价交联的水凝胶，以控制释放治疗 代理商
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公开(公告)号：US07597882B2
公开(公告)日：2009-10-06
申请号：US11789459
申请日：2007-04-24
IPC分类号： A61K31/74 , C08F283/00 , C07K14/00
CPC分类号： A61L24/0005 , A61K47/60 , A61L24/0031 , A61L24/046 , A61L24/06 , A61L24/108 , C08H1/00 , C08L89/00 , C08L71/02 , C08L39/06
摘要： Some aspects of this disclosure relate to a method for crosslinking a biological fluid comprising combining a biological fluid with a crosslinker to covalently crosslink proteins endogenous to the biological fluid to form a crosslinked gel. Examples of a biological fluid are blood, plasma, or serum.
摘要翻译： 本公开的一些方面涉及用于交联生物流体的方法，包括将生物流体与交联剂组合以共价交联生物流体内源的蛋白质以形成交联凝胶。 生物流体的实例是血液，血浆或血清。
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公开(公告)号：US20090198177A1
公开(公告)日：2009-08-06
申请号：US12012606
申请日：2008-02-04
IPC分类号： A61M37/00
CPC分类号： A61B17/0057 , A61B2017/00495 , A61B2017/0065
摘要： Certain embodiments include a surgical delivery system for a medical sealant including a packaging system with a detachable a sterile surface for mixing the sealant as needed for application.
摘要翻译： 某些实施方案包括用于医用密封剂的手术递送系统，其包括具有可拆卸的无菌表面的包装系统，用于根据需要混合密封剂。
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公开(公告)号：US20090017097A1
公开(公告)日：2009-01-15
申请号：US11825848
申请日：2007-07-09
IPC分类号： A61K9/10 , A61K31/7088 , A61K9/127 , A61P27/00 , A61K38/00
CPC分类号： A61K47/10 , A61K9/0019 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K31/196 , A61K31/405 , A61K31/4422 , A61K31/445 , A61K31/4458 , A61K31/496 , A61K31/573 , A61K31/58
摘要： Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
摘要翻译： 本公开的一些方面涉及治疗影响患者眼睛的眼科疾病的方法，包括在眼周，眼内或玻璃体外部位置原位形成共价交联的水凝胶，以控制释放治疗 代理商
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公开(公告)号：US20080214695A1
公开(公告)日：2008-09-04
申请号：US12069821
申请日：2008-02-13
IPC分类号： A61L24/04
CPC分类号： A61K47/34 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K31/74 , A61K47/42 , A61L24/106 , A61L27/18 , A61L27/50 , A61L31/06 , C07K14/75 , C08G63/08 , C08G63/912 , C08L89/00 , G06K7/10831 , G06K2207/1016 , C08L2666/02
摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
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