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124 条记录 (耗时 0.048 秒)

    Tumor necrosis factor receptor 5
    92.
    发明授权
    Tumor necrosis factor receptor 5 失效
    肿瘤坏死因子受体5

    公开(公告)号：US06455040B1

    公开(公告)日：2002-09-24

    申请号：US09573986

    申请日：2000-05-18

    申请人： Ying-Fei Wei ,  Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben

    发明人： Ying-Fei Wei ,  Jian Ni ,  Reiner L. Gentz ,  Steven M. Ruben

    IPC分类号： A61K39395

    CPC分类号： A61K31/522 ,  A61K31/66 ,  A61K39/395 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  A61K2300/00

    摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same as well as anti-TRID antibodies. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

    摘要翻译： 本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。 更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。 还提供了TRID多肽，载体，宿主细胞以及用于产生它们的重组方法以及抗TRID抗体也是如此。 本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。 还提供了利用这种组合物的诊断和治疗方法。

    Use of an antibody that binds human tumor necrosis factor receptor-like 2
    94.
    发明授权
    Use of an antibody that binds human tumor necrosis factor receptor-like 2 有权
    使用结合人类肿瘤坏死因子受体的抗体2

    公开(公告)号：US07824675B2

    公开(公告)日：2010-11-02

    申请号：US12241203

    申请日：2008-09-30

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/2878 ,  C07K2317/73 ,  C07K2319/30

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    Human Tumor Necrosis Factor Receptor-Like 2
    96.
    发明申请
    Human Tumor Necrosis Factor Receptor-Like 2 失效
    人类肿瘤坏死因子受体样2

    公开(公告)号：US20090131319A1

    公开(公告)日：2009-05-21

    申请号：US12235837

    申请日：2008-09-23

    申请人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen Patricia Lyn ,  Mark Robert Hurle

    发明人： Jian Ni ,  Craig A. Rosen ,  Reiner L. Gentz ,  Sally Doreen Patricia Lyn ,  Mark Robert Hurle

    IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/63 ,  C12N15/09 ,  C12N5/00 ,  C12P21/06 ,  C07K14/00 ,  C07K16/00

    CPC分类号： C07K14/7151

    摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

    摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。

    CD33-Like Protein
    97.
    发明申请
    CD33-Like Protein 审中-公开
    CD33样蛋白

    公开(公告)号：US20090081727A1

    公开(公告)日：2009-03-26

    申请号：US12020205

    申请日：2008-01-25

    申请人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

    IPC分类号： C12P21/02 ,  C07H21/00 ,  C12N15/63 ,  C07K16/28 ,  C12N15/87 ,  C12N5/10

    CPC分类号： C07K14/70596

    摘要： The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments targeting cells expressing CD33-like polypeptides.

    摘要翻译： 本发明涉及一种新型的CD33样蛋白。 特别地，提供编码CD33样蛋白质的分离的核酸分子。 重组载体和宿主细胞也提供重组CD33样多肽。 本发明还提供了在针对表达CD33样多肽的细胞的肿瘤或炎性疾病诊断或预后和治疗性治疗期间有用的方法。

    Death domain containing receptor 4 antibodies and methods
    98.
    发明授权
    Death domain containing receptor 4 antibodies and methods 有权
    含有受体4抗体的死亡域和方法

    公开(公告)号：US07452538B2

    公开(公告)日：2008-11-18

    申请号：US10648786

    申请日：2003-08-27

    申请人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    发明人： Jian Ni ,  Craig A. Rosen ,  James G. Pan ,  Reiner L. Gentz ,  Vishva M. Dixit

    IPC分类号： A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  C07K16/30

    CPC分类号： C07K16/2878 ,  A61K38/00 ,  A61K39/39541 ,  C07K14/70578 ,  C07K14/7151 ,  C07K2319/30 ,  C12N2799/026 ,  Y02A50/412 ,  A61K2300/00

    摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.

    摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。

    CD33-like protein
    100.
    发明授权
    CD33-like protein 失效
    CD33样蛋白

    公开(公告)号：US07374764B2

    公开(公告)日：2008-05-20

    申请号：US10413518

    申请日：2003-04-15

    申请人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

    发明人： Jian Ni ,  Reiner L. Gentz ,  Craig A. Rosen

    IPC分类号： G01N33/53 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A61K39/00 ,  A61K38/00 ,  A01N37/18

    CPC分类号： C07K14/70596

    摘要： The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments targeting cells expressing CD33-like polypeptides.

    摘要翻译： 本发明涉及一种新型的CD33样蛋白。 特别地，提供编码CD33样蛋白质的分离的核酸分子。 重组载体和宿主细胞也提供重组CD33样多肽。 本发明还提供了在针对表达CD33样多肽的细胞的肿瘤或炎性疾病诊断或预后和治疗性治疗期间有用的方法。