公开(公告)号：US20130022564A1

公开(公告)日：2013-01-24

申请号：US13556089

申请日：2012-07-23

申请人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

发明人： Jie Zhang ,  Kevin S. Warner ,  Sanjay Sharma

IPC分类号： A61K31/522 ,  A61P31/12 ,  A61P31/10 ,  A61K31/4174

CPC分类号： A61K31/74 ,  A61K9/0014 ,  A61K9/7015 ,  A61K31/4174 ,  A61K31/522 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/38

摘要： The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug for treating various skin infections, such as fungal, bacterial, and/or viral skin infections. The formulation can include anti-infective drug, solvent vehicle, and solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained periods of time. The non-volatile solvent system can also act to plasticize the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

摘要翻译： 本发明涉及固化粘合剂制剂，药物递送方法和用于皮肤递送用于治疗各种皮肤感染例如真菌，细菌和/或病毒性皮肤感染的药物的固化层。 制剂可以包括抗感染药物，溶剂载体和固化剂。 溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系。 非挥发性溶剂体系可以有助于以治疗有效率持续持续时间的药物递送。 非挥发性溶剂体系也可以起到塑化固化剂的作用。 在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。 当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

公开(公告)号：US20130011365A1

公开(公告)日：2013-01-10

申请号：US13527158

申请日：2012-06-19

申请人： Weizheng XU ,  Greg Delahanty ,  Ling Wei ,  Jie Zhang

发明人： Weizheng XU ,  Greg Delahanty ,  Ling Wei ,  Jie Zhang

IPC分类号： A61K31/519 ,  A61K33/24 ,  A61K31/7008 ,  A61K38/21 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/664 ,  A61P35/00 ,  A61P35/02 ,  A61K38/14 ,  A61K31/704 ,  A61K38/20

CPC分类号： A61K31/519 ,  A61K31/53 ,  C07D487/06 ,  C07D519/00

摘要： The present invention relates to tetraaza phenalen-3-one compounds which inhibit poly (ADP-ribose) polymerase (PARP) and are useful in the chemosensitization of cancer therapeutics. The induction of peripheral neuropathy is a common side-effect of many of the conventional and newer chemotherapies. The present invention further provides means to reliably prevent or cure chemotherapy-induced neuropathy. The invention also relates to the use of the disclosed PARP inhibitor compounds in enhancing the efficacy of chemotherapeutic agents such as temozolomide. The invention also relates to the use of the disclosed PARP inhibitor compounds to radio sensitize tumor cells to ionizing radiation. The invention also relates to the use of the disclosed PARP inhibitor compounds for treatment of cancers with DNA repair defects.

摘要翻译： 本发明涉及抑制聚（ADP-核糖）聚合酶（PARP）并可用于癌症治疗剂的化学敏化的四氮芥苯并三氮唑-3-酮化合物。 周围神经病变的诱导是许多常规和较新的化学疗法的常见副作用。 本发明还提供了可靠地预防或治愈化疗诱发的神经病变的方法。 本发明还涉及所公开的PARP抑制剂化合物在增强化疗剂如替莫唑胺的功效中的用途。 本发明还涉及所公开的PARP抑制剂化合物对肿瘤细胞对电离辐射的敏感性的应用。 本发明还涉及所公开的PARP抑制剂化合物用于治疗具有DNA修复缺陷的癌症的用途。

公开(公告)号：US08333599B2

公开(公告)日：2012-12-18

申请号：US12383516

申请日：2009-03-25

申请人： Yong-Chun Xu ,  Jie Zhang ,  Chao-Tung Huang ,  Xiao-Hua Liu

发明人： Yong-Chun Xu ,  Jie Zhang ,  Chao-Tung Huang ,  Xiao-Hua Liu

IPC分类号： H01R12/00

CPC分类号： H01R13/6658 ,  H01R13/6594 ,  H01R13/7175 ,  H01R13/7197 ,  H01R24/62

摘要： A modular jack (3) has an insulative housing (6), a printed circuit board (92), a number of cores (931-934) and a magnetic core (935), a number of conductive wires (936-939) respectively wind around the cores and then around the magnetic core together, and a number of grounding wires. The grounding wires has a first grounding wire having one end connected to the conductive wire and another end winding around the magnetic core for grounding, and other grounding wires respectively having one end load connected to the corresponding conductive wire and opposite end load directly connected to the first grounding wire.

摘要翻译： 模块插座（3）具有绝缘壳体（6），印刷电路板（92），多个芯（931-934）和磁芯（935），多个导线（936-939） 围绕磁芯缠绕，然后围绕磁芯在一起，以及多个接地线。 接地线具有第一接地线，其一端连接到导线，另一端缠绕在磁芯上用于接地，以及其它接地线，其分别具有一端负载连接到相应的导线和相对端负载，直接连接到 第一接地线。

公开(公告)号：US08285526B2

公开(公告)日：2012-10-09

申请号：US12629273

申请日：2009-12-02

申请人： Jie Zhang ,  Jiun-Der Yu

发明人： Jie Zhang ,  Jiun-Der Yu

IPC分类号： G06F7/60 ,  G06F17/10

CPC分类号： G06F7/60 ,  G06F17/5018

摘要： A system and method for simulating a droplet on a substrate with a moving contact line. The height of the droplet above the substrate is represented as a height function. A height evolution equation represents how the height of a droplet with moving contact line varies over time. The height function at a first point in space and a first point in time is calculated. An extrapolated height value at the first point in time is based on the height function at the first point in space and the first point in time, and the contact line at the first point in time. The extrapolated height value is at a second point in space below the substrate. The height evolution equation is used to calculate the height function at a second point in time based upon the extrapolated height value at the first point in time.

摘要翻译： 一种用于利用移动接触线模拟基底上的液滴的系统和方法。 衬底上方的液滴的高度表示为高度函数。 高度演化方程式表示具有移动接触线的液滴的高度随时间而变化。 计算空间中的第一点和第一时间点的高度函数。 第一时间点的外推高度值基于空间第一点和第一时间点的高度函数，以及第一时间点的接触线。 外推高度值位于衬底下方的空间的第二点。 高度演化方程用于基于第一时间点的外推高度值计算第二时间点的高度函数。

公开(公告)号：US20120231984A1

公开(公告)日：2012-09-13

申请号：US13416073

申请日：2012-03-09

申请人： Jie Zhang ,  Gongde Liu ,  Yuekui Zhai

发明人： Jie Zhang ,  Gongde Liu ,  Yuekui Zhai

IPC分类号： C10M149/10

CPC分类号： C10M161/00 ,  C10M163/00 ,  C10M2203/02 ,  C10M2203/0206 ,  C10M2207/028 ,  C10M2215/086 ,  C10M2219/046 ,  C10M2223/045 ,  C10N2230/04 ,  C10N2230/06 ,  C10N2230/10 ,  C10N2230/26 ,  C10N2230/52 ,  C10N2240/102 ,  C10N2270/02 ,  F01M9/02

摘要： A marine lubricating oil composite additive is provided. Based on the total weight of the composite additive, said marine lubricating oil composite additive comprises: 25-45% sulfonate detergent with superhigh base number, 40-60% phenolate detergent with low base number, 0-8% dispersing agent, 0-4% antiwear agent, and 10-20% Group I base oil with high viscosity index which is selected from the group consisting of 400SN, 500SN and 600SN. The composite additive of the present invention can satisfy the requirement of BOB system about the viscosity and base number, and can be blended with many system oils under a number of domestic and foreign brands so as to provide cylinder lubricating oils with different base numbers. The composite additive of the present invention has good adaptability and excellent performances in terms of antiwear, antioxidization and high temperature detergency, which meet the requirement of marine engines about the performance of cylinder lubricating oils.

摘要翻译： 提供海洋润滑油复合添加剂。 基于复合添加剂的总重量，所述海洋润滑油复合添加剂包括：具有超高碱值的25-45％磺酸盐洗涤剂，低碱值的40-60％苯酚洗涤剂，0-8％分散剂，0-4 ％抗磨剂，10〜20％高粘度指数的I组基础油，选自400SN，500SN和600SN。 本发明的复合添加剂可以满足BOB系统对粘度和碱值的要求，并可与许多国内外许多品牌的系统油混合，以提供不同碱值的油缸润滑油。 本发明的复合添加剂在抗磨损，抗氧化和高温洗涤等方面具有良好的适应性和优异的性能，满足船用发动机关于气缸润滑油性能的要求。

公开(公告)号：US08221546B2

公开(公告)日：2012-07-17

申请号：US12055725

申请日：2008-03-26

申请人： Jie Zhang

发明人： Jie Zhang

IPC分类号： C30B21/02

CPC分类号： C30B25/18 ,  C30B29/36

摘要： A method of epitaxially growing a SiC layer on a single crystal SiC substrate is described. The method includes heating a single-crystal SiC substrate to a first temperature of at least 1400° C. in a chamber, introducing a carrier gas, a silicon containing gas and carbon containing gas into the chamber; and epitaxially growing a layer of SiC on a surface of the SiC substrate. The SiC substrate is heated to the first temperature at a rate of at least 30° C./minute. The surface of the SiC substrate is inclined at an angle of from 1° to 3° with respect to a basal plane of the substrate material.

摘要翻译： 描述了在单晶SiC衬底上外延生长SiC层的方法。 该方法包括将单晶SiC衬底加热到​​腔室中至少1400℃的第一温度，将载气，含硅气体和含碳气体引入腔室中; 并且在SiC衬底的表面上外延生长SiC层。 将SiC衬底以至少30℃/分钟的速率加热至第一温度。 SiC衬底的表面相对于衬底材料的基面以1°至3°的角度倾斜。

公开(公告)号：US08200781B2

公开(公告)日：2012-06-12

申请号：US13198551

申请日：2011-08-04

申请人： Pieyu Yue ,  Teng Shi ,  Jie Zhang ,  Li Chen ,  Xin Fu

发明人： Pieyu Yue ,  Teng Shi ,  Jie Zhang ,  Li Chen ,  Xin Fu

IPC分类号： G06F15/16

CPC分类号： H04L65/608 ,  H04L12/189 ,  H04L51/24 ,  H04L65/1059 ,  H04L65/4076 ,  H04L67/06

摘要： A method for transporting/receiving notification messages via File Delivery over Unidirectional Transport (FLUTE) includes: At the transmitting end, a server carries a notification content in a transport object and carries notification related information and a transport object identifier (TOI) of the transport object carrying the notification content in a first file description table (FDT), and then sends the first FDT and the transport object carrying the notification content in a FLUTE session; the receiving end obtains the notification related information and the TOI of the transport object carrying the notification content from the first FDT, and receives the transport object carrying the notification content according to the obtained related information and the TOI. A server for transporting notification messages via FLUTE, a FLUTE server, a content server and a terminal are also disclosed. With the present invention, the notification transport procedure is simpler and the reliability of notification transport is better.

摘要翻译： 一种通过单向传输（FLUTE）通过文件传送来传送/接收通知消息的方法包括：在发送端，服务器在传输对象中携带通知内容，并携带通知相关信息和传输的传输对象标识符（TOI） 在第一文件描述表（FDT）中携带通知内容的对象，然后在FLUTE会话中发送携带通知内容的第一FDT和传送对象; 接收端从第一FDT获得携带通知内容的传送对象的通知相关信息和TOI，并根据获得的相关信息和TOI接收携带通知内容的传送对象。 还公开了用于通过FLUTE，FLUTE服务器，内容服务器和终端传送通知消息的服务器。 利用本发明，通知传送过程更简单，通知传输的可靠性更好。

公开(公告)号：US20120108773A1

公开(公告)日：2012-05-03

申请号：US13284744

申请日：2011-10-28

申请人： Chao Wang ,  Chuanqing Li ,  Guozhu Yu ,  Aimin Liang ,  Jie Zhang ,  Lin Xu ,  Pengfei Lv ,  Huiling Liu

发明人： Chao Wang ,  Chuanqing Li ,  Guozhu Yu ,  Aimin Liang ,  Jie Zhang ,  Lin Xu ,  Pengfei Lv ,  Huiling Liu

IPC分类号： C08F36/08 ,  C08F4/649 ,  C08F2/00

CPC分类号： C08F36/08 ,  C08F136/08 ,  C08F4/6494

摘要： Disclosed are catalyst compositions for isoprene polymerization formed from components comprising (A) at least one titanium halide; (B) at least one organic aluminum compound comprising at least one alkyl aluminum of formula AlR3, wherein each of the three Rs is independently chosen from linear and branched C1-6 alkyl groups; and (C) at least one electron donor comprising at least one polyether compound of formula (I) and/or at least one tetrahydro-furfuryl ether compound of formula (II). Also disclosed are processes for preparation of the catalyst compositions and processes using the catalyst compositions for isoprene polymerization.

摘要翻译： 公开了由组分（A）至少一种卤化钛组成的异戊二烯聚合催化剂组合物， （B）至少一种包含至少一种式AlR 3的烷基铝的有机铝化合物，其中三个R 3中的每一个独立地选自直链和支链C 1-6烷基; 和（C）包含至少一种式（I）的聚醚化合物和/或至少一种式（II）的四氢糠基醚化合物的至少一种电子给体。 还公开了制备催化剂组合物的方法和使用该催化剂组合物用于异戊二烯聚合的方法。

公开(公告)号：US08128913B1

公开(公告)日：2012-03-06

申请号：US12316121

申请日：2008-12-08

申请人： James A. Roszell ,  Jie Zhang

发明人： James A. Roszell ,  Jie Zhang

IPC分类号： A61K8/00 ,  A61K8/18 ,  A61Q17/04

CPC分类号： A61Q17/04 ,  A61K8/8164 ,  A61K8/8182

摘要： A sunscreen composition is provided according to the present invention. The sunscreen composition includes a skin bonding polymer composition comprising a hydrophobic polymer/hydrophilic polymer adduct, at least one sunscreen active agent comprising a UV-A absorber, and water in an amount of affected to provide a the composition with the texture suitable for application to skin. The hydrophobic polymer/hydrophilic polymer adduct comprises: (i) hydrophobic polymer composition comprising a mixture of a lower poly(vinylpyrrolidone/alkylene) polymer wherein the alkylene group contains about 10 to about 24 carbon atoms and a higher poly(vinylpyrrolidone/alkylene) polymer wherein the alkylene group contains greater than about 24 carbon atoms; and (ii) hydrophilic polymer composition comprising carboxylic acid groups, hydroxyl groups, or both carboxylic acid groups and hydroxyl groups.

摘要翻译： 根据本发明提供防晒组合物。 防晒组合物包括皮肤粘合聚合物组合物，其包含疏水性聚合物/亲水性聚合物加合物，至少一种包含UV-A吸收剂的防晒活性剂和受影响的量的水，以提供具有适合应用于 皮肤。 疏水性聚合物/亲水性聚合物加合物包括：（i）包含低聚（乙烯基吡咯烷酮/亚烷基）聚合物的混合物的疏水性聚合物组合物，其中亚烷基含有约10至约24个碳原子和较高的聚（乙烯基吡咯烷酮/亚烷基）聚合物 其中亚烷基含有大于约24个碳原子; 和（ii）包含羧酸基团，羟基或羧酸基团和羟基基团的亲水性聚合物组合物。

公开(公告)号：US20110295975A1

公开(公告)日：2011-12-01

申请号：US13198551

申请日：2011-08-04

申请人： Peiyu Yue ,  Teng Shi ,  Jie Zhang ,  Li Chen ,  Xin Fu

发明人： Peiyu Yue ,  Teng Shi ,  Jie Zhang ,  Li Chen ,  Xin Fu

IPC分类号： G06F15/16

CPC分类号： H04L65/608 ,  H04L12/189 ,  H04L51/24 ,  H04L65/1059 ,  H04L65/4076 ,  H04L67/06

摘要： A method for transporting/receiving notification messages via File Delivery over Unidirectional Transport (FLUTE) includes: At the transmitting end, a server carries a notification content in a transport object and carries notification related information and a transport object identifier (TOI) of the transport object carrying the notification content in a first file description table (FDT), and then sends the first FDT and the transport object carrying the notification content in a FLUTE session; the receiving end obtains the notification related information and the TOI of the transport object carrying the notification content from the first FDT, and receives the transport object carrying the notification content according to the obtained related information and the TOI. A server for transporting notification messages via FLUTE, a FLUTE server, a content server and a terminal are also disclosed. With the present invention, the notification transport procedure is simpler and the reliability of notification transport is better.

摘要翻译： 一种通过单向传输（FLUTE）通过文件传送来传送/接收通知消息的方法包括：在发送端，服务器在传输对象中携带通知内容，并携带通知相关信息和传输的传输对象标识符（TOI） 在第一文件描述表（FDT）中携带通知内容的对象，然后在FLUTE会话中发送携带通知内容的第一FDT和传送对象; 接收端从第一FDT获得携带通知内容的传送对象的通知相关信息和TOI，并根据获得的相关信息和TOI接收携带通知内容的传送对象。 还公开了用于通过FLUTE，FLUTE服务器，内容服务器和终端传送通知消息的服务器。 利用本发明，通知传送过程更简单，通知传输的可靠性更好。