Abstract:
This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.
Abstract:
Subject matter includes exemplary flexible rules for defining an information management process, for example a process that manages information being transferred between databases or with respect to an exemplary metadirectory. The flexible rules have inherent logic to define part of an information management action or a database structure and perform a call out for custom logic. The custom logic performs or defines another part of the information management action or database structure. Besides the exemplary flexible rules, the subject matter describes exemplary identity information management processes, engines, and related methods.
Abstract:
Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor.
Abstract:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract:
Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract:
Changes to references are propagated between entities in correlated namespaces. A first object in one external namespace refers to a second object in the one external namespace. The first object and the second object have associated central representations in a central namespace. A change to that reference is propagated to a third object in a third namespace by evaluating the associations between the central representations in the central namespace to determine if the third object is associated with one of the central representations, and if so, propagating the change to the reference. A user interface for configuring the flow of the propagations is also described.
Abstract:
Disclosed are compounds that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
Abstract:
A new Fast Recovery Plus (FR+) mechanism, and associated method, for wireless and/or mobile network applications to control data flow and avoid network congestion in a TCP/IP packet-switched network.
Abstract:
Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
Abstract:
A method for retrieving, decoding, and processing codes in an intermediate language generated from object specifying languages such as HTML and JAVA is disclosed. The codes in the intermediate language are decoded and processed on a minimally featured and minimally powered machine to generate a screen of information with selections thereon for the user. The file corresponding to the chosen selection is retrieved, decoded, processed, and displayed to the user again for selection. Codes in a simple scripting language are also provided to facilitate the processing of commands.