公开(公告)号：US09855432B2

公开(公告)日：2018-01-02

申请号：US13244415

申请日：2011-09-24

申请人： Peter J. Yoo ,  Michael A. Moffitt ,  Kerry Bradley

发明人： Peter J. Yoo ,  Michael A. Moffitt ,  Kerry Bradley

IPC分类号： A61N1/36 ,  A61N1/372

CPC分类号： A61N1/37247 ,  A61N1/36135 ,  A61N1/36185

摘要： A system for a tissue stimulator coupled to an array of electrodes. The system comprises a user-controlled input device configured for generating control signals, and at least one processor configured for generating a plurality of stimulation parameter sets in response to the control signals that, when applied to the electrodes, will shift electrical current between electrodes to modify a region of tissue activation. The processor(s) is further configured for computing an estimate of the region of tissue activation, and for generating display signals capable of prompting a monitor to display an animated graphical representation of the computed estimate of the region of tissue activation.

公开(公告)号：US09724513B2

公开(公告)日：2017-08-08

申请号：US12550213

申请日：2009-08-28

申请人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K. L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

发明人： Courtney Lane ,  Rafael Carbunaru ,  Kerry Bradley ,  David K. L. Peterson ,  Andrew DiGiore ,  Michael Moffitt

IPC分类号： A61N1/08 ,  A61N1/36

CPC分类号： A61N1/36021 ,  A61B5/021 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/04004 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/112 ,  A61B5/4812 ,  A61B5/4836 ,  A61M5/1723 ,  A61N1/0529 ,  A61N1/08 ,  A61N1/306 ,  A61N1/36025 ,  A61N1/36031 ,  A61N1/36034 ,  A61N1/3605 ,  A61N1/3606 ,  A61N1/36062 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36171 ,  A61N1/36178

摘要： A method and neurostimulation system for treating a patient are provided. A plurality of pulsed electrical waveforms are respectively delivered within a plurality of timing channels of the neurostimulation system, thereby treating the patient. Sets of stimulation pulses within the pulsed electrical waveforms that will potentially overlap temporally are predicted. Stimulation pulses in the respective pulsed electrical waveforms are temporally shifted in a manner that prevents overlap of the potentially overlapping pulse sets while preventing frequency locking between the timing channels.

公开(公告)号：US09238138B2

公开(公告)日：2016-01-19

申请号：US13231493

申请日：2011-09-13

申请人： Dongchul Lee ,  Michael Moffitt ,  Christopher Ewan Gillespie ,  Kerry Bradley

发明人： Dongchul Lee ,  Michael Moffitt ,  Christopher Ewan Gillespie ,  Kerry Bradley

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/378 ,  A61N1/39

CPC分类号： A61N1/36146 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36036 ,  A61N1/36046 ,  A61N1/3605 ,  A61N1/3606 ,  A61N1/36135 ,  A61N1/37247 ,  A61N1/378 ,  A61N1/3787 ,  A61N1/3906

摘要： A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.

摘要翻译： 提供了一种用于向患者提供治疗的方法，电组织刺激系统和程序员。 电极被放置在患者的组织（例如，脊髓组织）的附近，电刺激能量根据定义的波形从电极传送到组织，并且限定波形的脉冲形状被修改，从而改变 从电极传递到组织的电刺激能量。 可以通过选择多种不同的脉冲形状类型中的一种或通过调整脉冲形状的时间常数来修改脉冲形状。

公开(公告)号：US08712547B2

公开(公告)日：2014-04-29

申请号：US13036278

申请日：2011-02-28

申请人： Todd K. Whitehurst ,  James P. McGivern ,  Rafael Carbunaru ,  Matthew I. Haller ,  Tom Xiaohai He ,  Kerry Bradley

发明人： Todd K. Whitehurst ,  James P. McGivern ,  Rafael Carbunaru ,  Matthew I. Haller ,  Tom Xiaohai He ,  Kerry Bradley

IPC分类号： A61N1/05 ,  A61N1/372

CPC分类号： A61N1/0556 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/37205

摘要： An implantable stimulation device includes a device body; at least one set of partitioned electrodes disposed on a portion of the device body and configured and arranged for application of electrical stimulation to adjacent tissue; and insulating material separating the partitioned electrodes from each other. Each set of partitioned electrodes includes a plurality of partitioned electrodes disposed around a circumference of the device body. The implantable stimulation device can be configured and arranged so that each of the partitioned electrodes is independently programmable.

摘要翻译： 可植入刺激装置包括装置主体; 至少一组分隔电极，其设置在所述装置主体的一部分上，并被配置和布置成用于对相邻组织施加电刺激; 以及将分隔电极彼此分离的绝缘材料。 每组分隔电极包括围绕装置主体的圆周设置的多个分隔电极。 可植入式刺激装置可以被配置和布置成使得每个分隔电极可独立编程。

公开(公告)号：US08700180B2

公开(公告)日：2014-04-15

申请号：US13529928

申请日：2012-06-21

申请人： Kerry Bradley

发明人： Kerry Bradley

IPC分类号： A61N1/05

CPC分类号： A61N1/36071 ,  A61N1/0551 ,  A61N1/3605

摘要： A method of providing therapy to a patient having a disorder using an electrode located adjacent a peripheral target neural region. The method comprises conveying electrical stimulation energy from the electrode that stimulates a first set of nerve endings in the peripheral target neural region. The method further comprises increasing an activation threshold of a second set of nerve endings in the peripheral target neural region, thereby rendering the second set of nerve endings less excitable to the electrical stimulation energy. The first set of nerve endings are relatively far from the electrode and the second set of nerve endings are relatively near the electrode.

摘要翻译： 使用位于周边靶神经区域附近的电极向病人提供治疗的方法。 该方法包括从刺激第一组神经末梢的周围靶神经区域的电极输送电刺激能量。 所述方法还包括增加周围目标神经区域中第二组神经末梢的激活阈值，从而使第二组神经末梢对电刺激能量更不可兴奋。 第一组神经末梢距离电极相对较远，第二组神经末梢相对靠近电极。

公开(公告)号：US08688233B2

公开(公告)日：2014-04-01

申请号：US13529906

申请日：2012-06-21

申请人： Kerry Bradley ,  Dongchul Lee

发明人： Kerry Bradley ,  Dongchul Lee

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/36067 ,  A61N1/36171 ,  A61N1/36175

摘要： A method for using spinal cord stimulation to treat symptoms of motor disorders includes implanting a stimulation lead within a ventral portion of the epidural space. The lead is implanted with at least a portion of the electrodes facing the spinal cord. In a method for providing therapy to a patient suffering from a motor disorder, electrical stimulation energy is applied to at least one ventral column nerve fiber through the implanted stimulation lead. A peripheral region of the patient's body exhibits the symptoms of the motor disorder, and the ventral column nerve fiber to which the stimulation is applied innervates that peripheral region.

摘要翻译： 使用脊髓刺激来治疗运动障碍症状的方法包括将刺激引线植入硬膜外腔的腹侧部分。 植入铅的至少一部分电极面向脊髓。 在向患有运动障碍的患者提供治疗的方法中，通过植入的刺激引线向至少一个腹侧神经纤维施加电刺激能量。 患者身体的周边区域表现出运动障碍的症状，并且施加刺激的腹侧柱神经纤维支配该外周区域。

公开(公告)号：US08583262B2

公开(公告)日：2013-11-12

申请号：US12606065

申请日：2009-10-26

申请人： Jordi Parramon ,  David K. L. Peterson ,  Kerry Bradley ,  Rafael Carbunaru ,  Andrew DiGiore

发明人： Jordi Parramon ,  David K. L. Peterson ,  Kerry Bradley ,  Rafael Carbunaru ,  Andrew DiGiore

IPC分类号： A61N1/08

CPC分类号： A61N1/36125 ,  A61N1/0551 ,  A61N1/36157 ,  A61N1/36185

摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. Electrical stimulation current is conveyed from at least two of the electrodes to at least one of the electrodes along at least two electrical paths through tissue of the patient, and the electrical stimulation current is shifted between the electrical paths by actively adjusting one or more finite resistances respectively associated with one or more of the electrical paths.

摘要翻译： 提供了向植入电极阵列的患者提供治疗的方法和系统。 电刺激电流沿着沿着患者组织的至少两条电路径从至少两个电极传送到至少一个电极，并且电刺激电流通过主动调节一个或多个有限电阻而在电路径之间移动 分别与一个或多个电路径相关联。

公开(公告)号：US08473061B2

公开(公告)日：2013-06-25

申请号：US12761622

申请日：2010-04-16

申请人： Michael A. Moffitt ,  Thomas A. Oleksyn ,  Kerry Bradley ,  David K. L. Peterson ,  Courtney Lane ,  Anne Margaret Pianca

发明人： Michael A. Moffitt ,  Thomas A. Oleksyn ,  Kerry Bradley ,  David K. L. Peterson ,  Courtney Lane ,  Anne Margaret Pianca

IPC分类号： A61N1/00

CPC分类号： A61N1/0534 ,  A61N1/20 ,  A61N1/3606 ,  A61N1/36082 ,  A61N1/36182

摘要： A device for brain stimulation includes a lead having a longitudinal surface, a proximal end, a distal end and a lead body. The device also includes a plurality of electrodes disposed along the longitudinal surface of the lead near the distal end of the lead. The plurality of electrodes includes a first set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a first longitudinal position along the lead; and a second set of segmented electrodes comprising at least two segmented electrodes disposed around a circumference of the lead at a second longitudinal position along the lead. The device further includes one or more conductors that electrically couple together all of the segmented electrodes of the first set of segmented electrodes.

公开(公告)号：US08401665B2

公开(公告)日：2013-03-19

申请号：US11096662

申请日：2005-04-01

申请人： Kerry Bradley ,  Sunil K. Kapoor

发明人： Kerry Bradley ,  Sunil K. Kapoor

IPC分类号： A61N1/00

CPC分类号： A61N1/37241 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/36185 ,  A61N2001/083

摘要： Apparatus and methods for detecting lead migration through the use of measured artifactual data about the tissue in the vicinity of the lead.

公开(公告)号：US20130006325A1

公开(公告)日：2013-01-03

申请号：US13538022

申请日：2012-06-29

申请人： Carla M. Woods ,  James R. Thacker ,  David K. Peterson ,  Holly A. Segel ,  Susan E. Ford ,  Margaret E. Theriot ,  Kerry Bradley

发明人： Carla M. Woods ,  James R. Thacker ,  David K. Peterson ,  Holly A. Segel ,  Susan E. Ford ,  Margaret E. Theriot ,  Kerry Bradley

IPC分类号： A61N1/36

CPC分类号： A61N1/36071 ,  A61N1/08 ,  A61N1/36185 ,  A61N1/37241 ,  A61N1/37247

摘要： A programming system for selecting an electrode configuration for use in a medical electrical stimulator coupled to an electrode array. A programmer is configured for providing a set of electrode configurations for the electrode array, automatically testing a first portion of the set of electrode configurations in a first order, allowing the selection of one or more of the tested electrode configurations, determining whether a suitable number of electrode configurations from among the first portion have been selected within a predefined interval, and automatically testing a second portion of the set of electrode configurations in a second order if the suitable number of electrode configurations from among the first portion are not selected within the predefined interval. The programmer may further allow the selection of the tested electrode configurations, and adjusting parameters during the testing, wherein the adjusting is controllably shared in parallel between a clinician and a patient.

摘要翻译： 一种用于选择用于耦合到电极阵列的医用电刺激器中的电极配置的编程系统。 编程器被配置为提供用于电极阵列的一组电极配置，以一级自动测试该组电极配置的第一部分，允许选择一个或多个测试电极配置，确定是否合适数量 已经在预定义的间隔内选择了第一部分中的电极配置，并且如果来自第一部分中的适当数量的电极配置未被选择在预定义的范围内，则以二次自动测试该组电极配置的第二部分 间隔。 编程者可以进一步允许选择所测试的电极配置，并且在测试期间调整参数，其中调整在临床医生和患者之间可并行共享。