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公开(公告)号：US06485916B2
公开(公告)日：2002-11-26
申请号：US09788338
申请日：2001-02-21
IPC分类号： C12Q168
CPC分类号： C12Q1/6806 , C12Q1/6834
摘要： Focusing that abundant class genes abundantly present in a nucleic acid sample can comparatively easily be analyzed and readily be removed in a selective manner, a nucleic acid sample for expression analysis of rare expressed genes can be obtained by removing abundant genes therefrom, and analyses based upon the sample can be achieved.
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92.发明授权Audio decoding device for decoding coded audio information with multiple channels 失效用于解码具有多个声道的编码音频信息的音频解码装置公开(公告)号：US06460016B1
公开(公告)日：2002-10-01
申请号：US09685234
申请日：2000-10-10
申请人： Masahiro Sueyoshi , Shuji Miyasaka , Tukuru Ishito , Takeshi Fujita , Takashi Katayama , Masaharu Matsumoto , Tuyoshi Nakamura , Eiji Otomura , Akihisa Kawamura
发明人： Masahiro Sueyoshi , Shuji Miyasaka , Tukuru Ishito , Takeshi Fujita , Takashi Katayama , Masaharu Matsumoto , Tuyoshi Nakamura , Eiji Otomura , Akihisa Kawamura
IPC分类号： G10L2104
摘要： An audio decoding device for decoding audio information with multiple channels includes a coded information memory section for storing the coded audio information; an information transmission section for reading the coded audio information stored at an arbitrary position in the coded information memory section; and an audio decoding section for decoding the coded audio information read by the information transmission section and outputting the resultant audio information in accordance with a time axis, wherein the information transmission section includes a buffer memory for retaining an address of an actual pointer for reading the coded audio information in the coded information memory section so as not to be reread, an address of a temporary pointer for reading the coded audio information in the coded information memory section so as to be reread, actual pointer data read by the actual pointer, and temporary pointer data read by the temporary pointer.
摘要翻译： 用于对具有多个通道的音频信息进行解码的音频解码装置包括用于存储编码的音频信息的编码信息存储部分; 信息发送部，用于读取存储在编码信息存储部中的任意位置的编码音频信息; 以及音频解码部分，用于对由信息传输部分读取的编码音频信息进行解码，并根据时间轴输出所得到的音频信息，其中信息传输部分包括缓冲存储器，用于保存用于读取的实际指针的地址 编码信息存储部分中的编码音频信息不被重新读取，用于读取编码信息存储部分中的编码音频信息以便重新读取的临时指针的地址，由实际指针读取的实际指针数据，以及 由临时指针读取的临时指针数据。
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公开(公告)号：US6093783A
公开(公告)日：2000-07-25
申请号：US591243
申请日：1996-01-18
申请人： Takeshi Fujita , Chuzo Isoda , Sejin Pu
发明人： Takeshi Fujita , Chuzo Isoda , Sejin Pu
CPC分类号： C08G18/4837 , C08G18/6674 , D01F6/62 , D01F6/70 , D01F6/86 , C08G63/668 , Y10S528/906 , Y10T428/2904
摘要： This invention relates to a water-soluble fiber and a method of manufacturing the fiber. The water-soluble fiber of the invention is composed of a high molecular compound with a weight average molecular weight of not less than 10,000, which high molecular compound is obtainable by reacting a polyalkylene oxide compound, which is obtainable by addition polymerization of an ethylene oxide-containing alkylene oxide and an organic compound containing two active hydrogen atoms, with a polycarboxylic acid, an anhydride thereof, a lower alkyl ester thereof, or a diisocyanate and is manufactured by spinning the same high molecular compound. The water-soluble fiber of the invention is not only high in elongation and tensile strength but is readily soluble in water.
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94.发明授权
公开(公告)号：US6017954A
公开(公告)日：2000-01-25
申请号：US940123
申请日：1992-09-03
申请人： Moses J. Folkman , Donald Ingber , Takeshi Fujita
发明人： Moses J. Folkman , Donald Ingber , Takeshi Fujita
IPC分类号： A61K31/335 , A61K31/336 , C07D303/22 , C07D405/14 , C07D407/14 , C07D417/14 , C07D521/00 , A01N43/20
CPC分类号： C07D303/22 , A61K31/335 , A61K31/336 , C07D231/12 , C07D233/56 , C07D249/08 , C07D405/14 , C07D407/14 , C07D417/14
摘要： This invention relates to methods of using O-substituted fumagillol derivatives or salts thereof preferably, O-(N-chloroacetylcarbamoyl) fumagillol, O-(N-chloroacetylcarbamoyl)dihydrofumagillol or O-(N-chloracetylcarbamoyl)-6'b-hydroxyfumagillol, which have angiogenesis inhibitory activity, in the treatment and prevention of various diseases caused or advanced by abnormally hyperactive angiogenesis, especially various inflammatory diseases (rheumatism, psoriasis, etc.), diabetic retinopathy and cancer and other angiogenesis-dependent tumors, especially Kaposi's sarcoma, breast cancer, colon cancer.
摘要翻译： 本发明涉及使用O-取代的烟曲霉醇衍生物或其盐优选O-（N-氯乙酰基氨基甲酰基）烟曲霉醇，O-（N-氯乙酰基氨基甲酰基）二氢烟曲霉素或O-（N-氯乙酰基氨基甲酰基）-6'-羟基烟曲霉素的方法，其中 具有血管生成抑制活性，用于治疗和预防由异常血液生成异常引起或促进的各种疾病，特别是各种炎性疾病（风湿病，牛皮癣等），糖尿病性视网膜病变和癌症以及其它血管生成依赖性肿瘤，特别是卡波西肉瘤，乳腺癌 癌症，结肠癌。
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95.发明授权
公开(公告)号：US5682502A
公开(公告)日：1997-10-28
申请号：US490140
申请日：1995-06-14
摘要： In a speech synthesizer, each frame for generating a speech waveform has an expansion degree to which the frame is expanded or compressed in accordance with the production speed of synthetic speech. In accordance with the set speech production speed, the time interval between beat synchronization points is determined on the basis of the speed of the speech to be produced, and the time length of each frame present between the beat synchronization points is determined on the basis of the expansion degree of the frame. Parameters for producing a speech waveform in each frame are properly generated by the time length determined for the frame. In the speech synthesizer for outputting a speech signal by coupling phonemes constituted by one or a plurality of frames having phoneme vowel-consonant combination parameters (VcV, cV, or V) of the speech waveform, the number of frames can be held constant regardless of a change in the speech production speed. This prevents degradation in the tone quality or a variation in the processing quantity resulting from a change in the speech production speed.
摘要翻译： 在语音合成器中，用于产生语音波形的每个帧具有根据合成语音的生产速度来扩展或压缩帧的扩展度。 根据设定的语音生成速度，基于要产生的语音的速度来确定拍子同步点之间的时间间隔，并且基于在拍子同步点之间存在的每个帧的时间长度 框架的扩展程度。 用于产生每帧中的语音波形的参数通过为帧确定的时间长度适当地产生。 在语音合成器中，通过将由语音波形的音素元音辅音组合参数（VcV，cV或V）组成的一个或多个帧构成的音素耦合到语音信号中，可以将帧数保持不变，而不管 演讲生产速度的变化。 这防止了语音质量的劣化或由语音生成速度的变化导致的处理量的变化。
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96.发明授权
公开(公告)号：US5580402A
公开(公告)日：1996-12-03
申请号：US156034
申请日：1993-11-19
摘要： Disclosed is an aluminum alloy sheet having a chemical composition of an Si-containing Al--Mg--CU alloy. The aluminum alloy sheet exhibits a streak-shaped modulated structure at a diffraction grating points of an Al--Cu--Mg--system compound in the electron beam diffraction grating image. The above mentioned streak can be generated efficiently when the alloy essentially consists of 1.5 to 3.5% by weight of Mg, 0.3 to 1.0% by weight of Cu, 0.05 to 0.6% by weight of Si, and the balance of Al and inevitable impurities, and the ratio of Mg/Cu is in the range of 2 to 7. The alloy contains 0.01-0.50% of at least one element selected from the group consisting of Sn, Cd, and In.
摘要翻译： 公开了具有含Si的Al-Mg-Cu合金的化学组成的铝合金板。 铝合金板在电子束衍射光栅图像中的Al-Cu-Mg系化合物的衍射光栅点处呈现条纹状的调制结构。 当合金基本上由Mg，0.3〜1.0重量％的Cu，0.05〜0.6重量％的Si，余量的Al和不可避免的杂质组成时，能够有效地产生上述条纹， 并且Mg / Cu的比例在2〜7的范围内。该合金含有0.01-0.50％的选自Sn，Cd和In中的至少一种元素。
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公开(公告)号：US5458761A
公开(公告)日：1995-10-17
申请号：US378973
申请日：1995-01-27
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44704 , G01N27/44721 , G01N27/44743
摘要： Analysis of a nucleic acid samples having thousands of bases is conducted by capillary electrophoresis. The electrophoretic section is provided with a first capillary filled with an agarose gel and a second capillary filled with a polyacrylamide gel. An on-column detector is incorporated with the second capillary for optical detection. To fill a capillary with a gel, a solution is fed under high pressure from a first flow channel through a switching valve into a second flow channel connected to the capillary. To inject a sample in the capillary, a sample injector is connected to a switching valve passage, and a buffer solution is connected to the capillary through a flow channel and the switching valve. After switching the valve, the first passage is incorporated into the flow channel between the buffer solution and the capillary being filled. Then, the sample is electro-kinetically injected into the capillary. When conducting genetic polymorphism by electrophoresis, temperature control elements are provided to maintain the capillary at a predetermined temperature and a DNA sample device is provided to heat the sample to a temperature higher than a disassociation temperature thereof for directly injecting the heated sample into the capillary.
摘要翻译： 通过毛细管电泳分析具有数千个碱基的核酸样品。 电泳部分设置有填充有琼脂糖凝胶的第一毛细管和填充有聚丙烯酰胺凝胶的第二毛细管。 柱内检测器与第二毛细管并入，用于光学检测。 为了用凝胶填充毛细管，将溶液在高压下从第一流动通道通过切换阀进入连接到毛细管的第二流动通道。 为了在毛细管中注入样品，将样品注射器连接到切换阀通道，并且缓冲溶液通过流动通道和切换阀连接到毛细管。 在切换阀之后，第一通道被并入缓冲溶液和被填充的毛细管之间的流动通道中。 然后，将样品电动注射到毛细管中。 当通过电泳进行遗传多态性时，提供温度控制元件以将毛细管保持在预定温度，并且提供DNA样品装置以将样品加热到高于其解离温度的温度，以将加热的样品直接喷射到毛细管中。
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98.发明授权Driving circuit for solid-state image sensor and counter circuit used therein 失效其中使用的固态图像传感器和计数器电路的驱动电路
公开(公告)号：US5249054A
公开(公告)日：1993-09-28
申请号：US796574
申请日：1991-11-22
申请人： Isao Ihara , Yoshiaki Sone , Shinichi Tashiro , Takeshi Fujita
发明人： Isao Ihara , Yoshiaki Sone , Shinichi Tashiro , Takeshi Fujita
CPC分类号： H04N5/335 , H03K23/005
摘要： A counter circuit which incurs a uniform number of logic changes whether the clock signal is rising or falling is used in both a first counter circuit for measuring the reference signal for horizontal scanning period and a second counter circuit for measuring signals in the vertical blanking period. Since the number of logic changes of the flip-flops with respect to the clock signal is uniform, a driving circuit for a solid-state image sensor is realized in which noise in the vertical blanking period does not appear in the video period even if by using 1H delay line.
摘要翻译： 在用于测量水平扫描周期的参考信号的第一计数器电路和用于在垂直消隐周期中测量信号的第二计数器电路两者中都使用引起统计数量的逻辑改变的计数器电路，不管时钟信号是上升还是下降。 由于触发器相对于时钟信号的逻辑变化的数量是均匀的，因此实现了用于固态图像传感器的驱动电路，其中垂直消隐期间的噪声在视频周期内不出现，即使通过 使用1H延迟线。
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公开(公告)号：US5204397A
公开(公告)日：1993-04-20
申请号：US753762
申请日：1991-09-03
申请人： Hirohisa Maki , Takeshi Fujita , Katsuaki Matsuo , Kenji Motogami , Shigeo Mori
发明人： Hirohisa Maki , Takeshi Fujita , Katsuaki Matsuo , Kenji Motogami , Shigeo Mori
摘要： The invention relates to a method of improving the electric conductivity of resin. The method comprises compounding (A) a macromolecular compound obtained by crosslinking a polyether polyol and (B) a soluble electrolyte salt into matrix resin. The invention insures a marked improvement in the electric conductivity of resin without affecting its physical characteristics or causing an objectionable coloration.
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公开(公告)号：US5204345A
公开(公告)日：1993-04-20
申请号：US489010
申请日：1990-03-06
申请人： Shoji Kishimoto , Takeshi Fujita
发明人： Shoji Kishimoto , Takeshi Fujita
IPC分类号： C07D303/22 , C07D405/12
CPC分类号： C07D303/22 , C07D405/12
摘要： The present invention relates to a compound of the formula: ##STR1## wherein R.sup.1 is 2-methyl-1-propenyl group or isobutyl group; R.sup.2 is hydrogen atom, an optionally substituted aliphatic hydrocarbon residue or an optionally substituted acyl group, or a salt thereof.The compound (I) of the invention has, among others, angiogenesis inhibiting activity, cell-proliferation inhibiting activity and immune reaction inhibiting activity, thus being useful as medicines, etc.
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