Preparation of amines
    91.
    发明授权
    Preparation of amines 失效
    胺的制备

    公开(公告)号:US6057442A

    公开(公告)日:2000-05-02

    申请号:US159089

    申请日:1998-09-23

    摘要: Amines are prepared from primary or secondary alcohols and nitrogen compounds selected from the group of ammonia, primary and secondary amines, at from 80 to 250.degree. C. under pressures from 0.1 to 40 MPa with hydrogen in the presence of a catalyst comprising zirconium, copper and nickel, wherein the catalytically active composition comprises20-85% by weight of oxygen-containing zirconium compounds, calculated as ZrO.sub.2,1-30% by weight of oxygen-containing copper compounds, calculated as CuO,14-70% by weight of oxygen-containing nickel compounds, calculated as NiO, where the molar ratio of nickel to copper is greater than 1,0-10% by weight of oxygen-containing aluminum and/or manganese compounds, calculated as Al.sub.2 O.sub.3 and/or MnO.sub.2,and no oxygen-containing cobalt or molybdenum compounds.

    摘要翻译: 在含有锆,铜和铜的催化剂存在下,在氢气压力为0.1至40MPa的压力下,从伯,仲醇和选自氨,伯胺和仲胺的氮化合物制备胺。 和镍,其中催化活性组合物包含20-85重量%的以ZrO 2计算的含氧锆化合物,1-30重量%的以CuO计的含氧铜化合物,14-70重量% 以NiO计算的含氧镍化合物,其中镍与铜的摩尔比大于1-10重量%,以Al 2 O 3和/或MnO 2计算的含氧铝和/或锰化合物为0-10重量% 含氧钴或钼化合物。

    Computer gaming system
    92.
    发明授权
    Computer gaming system 失效
    电脑游戏系统

    公开(公告)号:US5941770A

    公开(公告)日:1999-08-24

    申请号:US851255

    申请日:1997-05-05

    摘要: The present invention comprises an intelligent gaming system that includes a game engine, simulation engine, and, in certain embodiments, a static evaluator. Embodiments of the invention include an intelligent, poker playing slot machine that allows a user to play poker for money against one or more intelligent, simulated opponents. The simulation engine generates actions for the simulated player(s). The simulation engine allows a real person, or user, to play against intelligent, simulated opponents. In addition, in certain embodiments a static evaluator offers another level of play in which the user can play against a predetermined criteria for winning. In one embodiment of the invention, the user plays against simulated opponent(s). In another embodiment of the invention, the user plays against simulated opponent(s) and against the predetermined criteria.

    摘要翻译: 本发明包括智能游戏系统,其包括游戏引擎,模拟引擎,以及在某些实施例中,静态评估器。 本发明的实施例包括一种智能的扑克玩老虎机,其允许用户针对一个或多个智能模拟对手玩钱扑克。 模拟引擎为模拟玩家生成动作。 模拟引擎允许真正的人或用户对智能模拟对手进行对抗。 此外,在某些实施例中,静态评估器提供另一个玩家级别,用户可根据预定的获胜标准进行游戏。 在本发明的一个实施例中,用户对模拟的对手进行打击。 在本发明的另一个实施例中,用户针对模拟对手并且抵制预定标准。

    Preparation of amines from olefins over oxides of group IVB or VIB or
mixtures thereof on carriers
    93.
    发明授权
    Preparation of amines from olefins over oxides of group IVB or VIB or mixtures thereof on carriers 失效
    IVB或VIB族氧化物或其混合物在载体上从烯烃制备胺

    公开(公告)号:US5780681A

    公开(公告)日:1998-07-14

    申请号:US869759

    申请日:1997-06-05

    摘要: Amines of general formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each hydrogen, C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.2 -C.sub.20 -alkynyl, C.sub.3 -C.sub.20 -cycloalkyl, C.sub.4 -C.sub.20 -alkylcycloalkyl, C.sub.4 -C.sub.20 -cycloalkylalkyl, aryl, C.sub.7 -C.sub.20 -alkylaryl or C.sub.7 -C.sub.20 -aralkyl, R.sup.1 and R.sup.2 together form a saturated or unsaturated C.sub.3 -C.sub.9 -alkylene chain and R.sup.3 or R.sup.5 is C.sub.21 -C.sub.200 -alkyl or C.sub.21 -C.sub.200 -alkenyl, or R.sup.3 and R.sup.5 together form a C.sub.2 -C.sub.12 -alkylene chain, are prepared by reacting an olefin of the general formula II ##STR2## where R.sup.3, R.sup.4, R.sup.5 and R.sup.6 have the above-mentioned meanings, with ammonia or primary or secondary amines of the general formula III ##STR3## where R.sup.1 and R.sup.2 have the abovementioned meanings, at from 200.degree. to 350.degree. C. and from 100 to 300 bar in the presence of a heterogeneous catalyst, by a process in which the heterogeneous catalyst used is an oxide of group IVB or VIB or a mixture thereof on a carrier.

    摘要翻译: 通式I(I)的胺其中R 1,R 2,R 3,R 4,R 5和R 6各自为氢,C 1 -C 20 - 烷基,C 2 -C 20 - 烯基,C 2 -C 20 - 炔基,C 3 -C 20 - 环烷基 C 4 -C 20烷基环烷基,C 4 -C 20环烷基烷基,芳基,C 7 -C 20烷基芳基或C 7 -C 20芳烷基,R 1和R 2一起形成饱和或不饱和的C 3 -C 9 - 亚烷基链,并且R 3或R 5是C 21 -C 200 - 烷基或C 21 -C 2-链烯基,或者R 3和R 5一起形成C 2 -C 12亚烷基链,通过使通式II的烯烃(II)反应,其中R3,R4,R5和R6具有 在具有上述含义的氨基或伯或仲胺中,其中R1和R2具有上述含义,在200-350℃和100-300巴的存在下, 的非均相催化剂,其中使用的非均相催化剂是IVB或VIB的氧化物或其载体上的混合物的方法。

    Preparation of N-heterocycles
    94.
    发明授权
    Preparation of N-heterocycles 失效
    N-杂环的制备

    公开(公告)号:US4929733A

    公开(公告)日:1990-05-29

    申请号:US207861

    申请日:1988-06-17

    IPC分类号: C07D209/08 C07D295/023

    摘要: N-heterocycles of the general formulae (I) and (II) ##STR1## where R.sup.1 and R.sup.4 to R.sup.9 are each hydrogen, alkyl, aryl, aralkyl, alkylaryl or cycloalkyl and R.sup.2 and R.sup.3 are each an alkyl, alkylaryl, substituted alkyl or cycloalkyl group, are prepared by a process in which an olefin of the formula (III) or (IV) ##STR2## where R.sup.2 to R.sup.9 have the above meanings, is reacted with NH.sub.3 or with a primary amine of the formula H.sub.2 NR.sup.1, where R.sup.1 has the above meanings, in the presence of a zeolite as a catalyst.

    摘要翻译: 通式(I)和(II)的N-杂环化合物其中R 1和R 4至R 9各自为氢,烷基,芳基,芳烷基,烷基芳基或环烷基,R 2和R 3各自为烷基,烷基芳基,取代的烷基或 环烷基的方法通过其中R 2至R 9具有上述含义的式(III)或(IV)的烯烃与NH 3或伯胺进行反应的方法制备 式H2NR1,其中R1具有上述含义,在作为催化剂的沸石存在下。

    Preparation of diamines
    95.
    发明授权
    Preparation of diamines 失效
    二胺的制备

    公开(公告)号:US4914241A

    公开(公告)日:1990-04-03

    申请号:US206755

    申请日:1988-06-15

    IPC分类号: C07C209/60

    CPC分类号: C07C209/60 Y02P20/582

    摘要: Diamines of the formula ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are each hydrogen, alkyl, aryl, alkoxy, aralkyl or cycloalkyl and X is a group of the formula(CR.sup.4 R.sup.5).sub.m (II)where R.sup.4 and R.sup.5 have the meanings given above for R.sup.1 and m is from 1 to 12, are prepared by a process in which a diamine of the formula ##STR2## where R.sup.1, R.sup.2 and X are the groups described above, is reacted with an olefin of the formula ##STR3## where R.sup.6 and R.sup.9 are each hydrogen or alkyl which is straight-chain in the .alpha.-position, in the presence of a zeolite as a catalyst.

    摘要翻译: 式(I)的二胺其中R 1,R 2和R 3各自为氢,烷基,芳基,烷氧基,芳烷基或环烷基,X为式(CR 4 R 5)m(II)的基团,其中R 4和R 5具有 对于R1和m给出的含义为1至12的方法通过以下方法制备:其中R1,R2和X为上述基团的式(III)的二胺与 式(VI)其中R 6和R 9各自为氢或在α位为直链的烷基,在作为催化剂的沸石存在下。

    Nucleic acid expression construct and its use as a cell proliferation marker
    96.
    发明授权
    Nucleic acid expression construct and its use as a cell proliferation marker 有权
    核酸表达构建体及其作为细胞增殖标志物的用途

    公开(公告)号:US09115206B2

    公开(公告)日:2015-08-25

    申请号:US13383580

    申请日:2010-07-15

    IPC分类号: C07K14/47 C12N15/63

    CPC分类号: C07K14/4738 C12N15/63

    摘要: A nucleic acid expression construct which encodes a fusion protein includes a reporter protein and a protein with a wild-type destruction signal. A sequence encoding the fusion protein is operably linked to a non-endogenous promoter. The fusion protein localizes during a cell cycle progression to subcellular structures selected from a cell cortex, a contractile ring, and a midbody.

    摘要翻译: 编码融合蛋白的核酸表达构建体包括报道蛋白和具有野生型破坏信号的蛋白质。 编码融合蛋白的序列与非内源启动子可操作地连接。 融合蛋白在细胞周期进展期间定位到选自细胞皮质,收缩环和中间体的亚细胞结构。