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公开(公告)号：US07317005B2
公开(公告)日：2008-01-08
申请号：US10775675
申请日：2004-02-10
IPC分类号： A61P9/00 , A61K31/55 , C07D487/00 , C07D513/00
CPC分类号： C07D471/04 , C07D513/04
摘要： The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译： 本发明涉及用作加压素受体拮抗剂的三环苯并二氮杂，用于治疗涉及增加的血管阻力和心功能不全的病症。 包含本发明的三环苯并二氮杂的药物组合物和治疗诸如高血压，充血性心力衰竭，心功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，肾血管痉挛，肾衰竭，脑水肿和缺血，中风，血栓形成或 还公开了保水性。
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![Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists](/abs-image/US/2005/08/30/US06936604B2/abs.jpg.150x150.jpg)
92.发明授权Bridged bicyclic amino acid-derived [1,4]benzodiazepine vasopressin receptor antagonists 有权桥连双环氨基酸衍生的[1,4]苯并二氮杂加压素受体拮抗剂公开(公告)号：US06936604B2
公开(公告)日：2005-08-30
申请号：US10269656
申请日：2002-10-11
IPC分类号： C07D487/18 , A61K31/5517 , A61P1/16 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P13/12 , C07D471/18 , C07D487/20 , C07D487/08 , A61K31/55 , C07D209/00 , C07D221/00 , C07D243/00
CPC分类号： C07D471/18 , C07D487/20
摘要： The invention is directed to bridged bicyclic amino acid-derived [1,4]benzodiazepine compounds, intermediates and pharmaceutical compositions thereof useful as vasopressin receptor antagonists and methods for treating vasopressin mediated disorders.
摘要翻译： 本发明涉及桥联的双环氨基酸衍生的[1,4]苯并二氮杂化合物，其用作加压素受体拮抗剂的中间体和药物组合物以及治疗加压素介导的病症的方法。
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公开(公告)号：US06828327B2
公开(公告)日：2004-12-07
申请号：US10008982
申请日：2001-12-06
申请人： Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
发明人： Gee-Hong Kuo , Han-Cheng Zhang , Catherine Prouty , Alan DeAngelis , Peter Connolly , William V. Murray , Lan Shen , Bruce Conway , Keith Demarest , Chandra R. Shah , Bruce E. Maryanoff , Kimberly B. White
IPC分类号： A61K3144
CPC分类号： C07D471/22 , C07D487/22 , C07D498/22 , C07D515/22
摘要： This invention is directed to macroheterocyclic compounds useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods for treating or ameliorating a kinase or dual-kinase mediated disorder.
摘要翻译： 本发明涉及可用作激酶或双重激酶抑制剂的大量杂环化合物，用于制备此类化合物的方法和用于治疗或改善激酶或双重激酶介导的病症的方法。
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94.发明授权Aminomethyl-pyrroloquinazoline compounds as thrombin receptor antagonists 有权氨基甲基吡咯并喹唑啉化合物作为凝血酶受体拮抗剂公开(公告)号：US06740657B2
公开(公告)日：2004-05-25
申请号：US10059707
申请日：2002-01-29
IPC分类号： A61K3805
CPC分类号： C07D487/04
摘要： The invention is directed to novel aminomethyl-pyrroloquinazoline compounds and pharmaceutical compositions thereof which are useful thrombin receptor or PAR-1 antagonists, methods for production thereof and methods for treating thrombin or PAR-1 mediated disorders.
摘要翻译： 本发明涉及可用于凝血酶受体或PAR-1拮抗剂的新型氨基甲基 - 吡咯并喹唑啉化合物及其药物组合物，其制备方法和治疗凝血酶或PAR-1介导的病症的方法。
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公开(公告)号：US06713475B2
公开(公告)日：2004-03-30
申请号：US09911605
申请日：2001-07-24
IPC分类号： A61K3155
CPC分类号： C07D471/04 , C07D513/04
摘要： The invention is directed to tricyclic benzodiazepines useful as vasopressin receptor antagonists for treating conditions involving increased vascular resistance and cardiac insufficiency. Pharmaceutical compositions comprising tricyclic benzodiazepines of the present invention and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, renal vasospasm, renal failure, cerebral edema and ischemia, stroke, thrombosis, or water retention are also disclosed.
摘要翻译： 本发明涉及用作加压素受体拮抗剂的三环苯并二氮杂，用于治疗涉及增加的血管阻力和心功能不全的病症。 包含本发明的三环苯并二氮杂的药物组合物和治疗诸如高血压，充血性心力衰竭，心功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，肾血管痉挛，肾衰竭，脑水肿和缺血，中风，血栓形成或 还公开了保水性。
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公开(公告)号：US06630451B1
公开(公告)日：2003-10-07
申请号：US09599826
申请日：2000-06-22
IPC分类号： C07K506
CPC分类号： C07K5/06191 , A61K38/00 , C07D235/26 , H01L2924/01013 , H01L2924/01023 , H01L2924/01024 , H01L2924/01027 , H01L2924/01029 , H01L2924/0104 , H01L2924/01042 , H01L2924/01044 , H01L2924/01045 , H01L2924/01046 , H01L2924/01047 , H01L2924/01074 , H01L2924/01076 , H01L2924/01077 , H01L2924/01078 , H01L2924/01079 , H05K3/4092
摘要： The invention is directed to novel benzimidazolone peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, Angiogenesis related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted benzimidazolone peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
摘要翻译： 本发明涉及可用作治疗与血栓形成，再狭窄，高血压，心力衰竭，心律失常，炎症，心绞痛，中风，动脉粥样硬化，缺血性疾病，血管发生相关疾病，癌症相关的疾病的凝血酶受体拮抗剂的新型苯并咪唑酮肽模拟化合物 ，和神经变性疾病。 还公开了包含本发明的取代的苯并咪唑酮肽模拟物的药物组合物和治疗由凝血酶受体介导的病症的方法。
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97.发明授权Tricyclic monosaccharide derivatives useful in treating acute ischemia-induced neurodegeneration 失效用于治疗急性缺血诱导的神经变性的三环单糖衍生物公开(公告)号：US06495523B1
公开(公告)日：2002-12-17
申请号：US09620510
申请日：2000-07-20
IPC分类号： A01N6100
CPC分类号： C07H11/00 , A61K31/357 , A61K31/7048 , C07H9/04
摘要： Anticonvulsant compounds of the general formula I: where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal injury, non-fatal cardiac arrest, or major surgical procedures. Furthermore, pharmaceutical compositions containing a compound of formula I as well as methods for their use are disclosed.
摘要翻译： 通式I的抗惊厥化合物：其中X，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义; 可用于治疗急性缺血诱发的神经退行性疾病，例如卒中发作，头部外伤，脊柱损伤，非致命性心脏骤停或主要外科手术。 此外，公开了含有式I化合物的药物组合物及其使用方法。
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公开(公告)号：US5827866A
公开(公告)日：1998-10-27
申请号：US482587
申请日：1995-06-07
IPC分类号： A61K38/00 , C07D277/56 , C07D277/64 , C07D417/06 , C07K5/065 , A61K31/425 , A01N43/78
CPC分类号： C07D417/06 , C07D277/56 , C07D277/64 , C07K5/06078 , A61K38/00
摘要： Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
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99.发明授权
公开(公告)号：US5523308A
公开(公告)日：1996-06-04
申请号：US486473
申请日：1995-06-07
IPC分类号： A61K38/00 , A61K38/06 , A61P7/02 , A61P43/00 , C07D277/56 , C07D417/06 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/087 , A61K31/445 , C07D413/06
CPC分类号： C07D417/06 , C07D277/56 , C07K5/0222 , C07K5/06026 , C07K5/06078 , C07K5/06095 , C07K5/06165 , C07K5/06191 , A61K38/00
摘要： Compounds of the Formula I: ##STR1## useful in the treatment of thrombin and trypsin related disorders.
摘要翻译： 式I化合物：可用于治疗凝血酶和胰蛋白酶相关病症。
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100.发明授权2-oxo-pyrrolo[1,2-A]benzimidazole-3-carboxyl derivatives useful in treating central nervous system disorders 失效可用于治疗中枢神经系统疾病的2-氧代 - 吡咯并[1,2-A]苯并咪唑-3-羧基衍生物
公开(公告)号：US5521200A
公开(公告)日：1996-05-28
申请号：US332687
申请日：1994-11-01
IPC分类号： C07D487/04 , A61K31/415
CPC分类号： C07D487/04
摘要： A compound of the general formula I; ##STR1## is disclosed as useful in treating disorders of the central nervous system. Pharmaceutical compositions and methods of treatment are also disclosed.
摘要翻译： 通式I的化合物;
我被公开用于治疗中枢神经系统疾病。 还公开了药物组合物和治疗方法。
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