公开(公告)号：US10576182B2

公开(公告)日：2020-03-03

申请号：US16155763

申请日：2018-10-09

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Xinping Wu ,  Matthew J. Fitz ,  Yue Wu

IPC: A61L24/00

Abstract: Liquid embolic preparations and medical treatment methods of using those preparations are described. In some embodiments, the preparations or solutions can transition from a liquid to a solid for use in the embolization. The preparations can include biocompatible polymers with covalently bound radioactive iodine isotopes.

公开(公告)号：US10543295B2

公开(公告)日：2020-01-28

申请号：US16505326

申请日：2019-07-08

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Steve Plotkin ,  Xinping Wu

IPC: C08F220/38 ,  C08F220/56 ,  C08F222/10 ,  C08F222/38 ,  C08F222/40 ,  A61K9/00 ,  A61K9/16 ,  A61L24/06 ,  A61L24/00

Abstract: Embolic particles are described. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer.

公开(公告)号：US20190194406A1

公开(公告)日：2019-06-27

申请号：US16258313

申请日：2019-01-25

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Gloria Hincapie ,  Clayton Harris ,  Yue Wu

IPC: C08J5/18 ,  A61K9/00 ,  A61L31/14 ,  A61K47/32 ,  C08F120/56 ,  A61L31/04 ,  A61L31/16

CPC classification number: C08J5/18 ,  A61K9/0024 ,  A61K47/32 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  C08F120/56 ,  C08F220/56 ,  C08F222/1006 ,  C08F222/385 ,  C08J2333/14 ,  C08J2333/26 ,  Y10T428/21

Abstract: Biodegradable, cross-linked polymer films and methods of making the same are described. The polymer films can be used for preventing adhesions following surgery and/or delivering therapeutic agents.

公开(公告)号：US10201562B2

公开(公告)日：2019-02-12

申请号：US15924028

申请日：2018-03-16

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61L24/00 ,  A61K31/78 ,  A61L24/04 ,  A61K9/00 ,  A61K47/32

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US20180200288A1

公开(公告)日：2018-07-19

申请号：US15924028

申请日：2018-03-16

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael J. Constant ,  Joshua Garretson

IPC: A61K31/785 ,  A61L24/00 ,  A61K31/78 ,  A61L24/04 ,  A61K9/00 ,  A61K47/32

CPC classification number: A61K31/785 ,  A61K9/0024 ,  A61K31/78 ,  A61K47/32 ,  A61L24/0089 ,  A61L24/046 ,  A61L2430/36

Abstract: Compositions are described comprising a polymer; a non-physiological pH solution; and a visualization agent; wherein the polymer is soluble in the non-physiological pH solution and insoluble at a physiological pH. Methods of forming the solutions and polymers are disclosed as well as methods of therapeutic use.

公开(公告)号：US20180085497A1

公开(公告)日：2018-03-29

申请号：US15719241

申请日：2017-09-28

Applicant: MicroVention, Inc.

Inventor： Gloria Hincapie ,  Xinping Wu ,  Yue Wu ,  Gregory M. Cruise

IPC: A61L31/04 ,  C08F236/20 ,  A61L31/14

CPC classification number: A61L24/0015 ,  A61B17/12109 ,  A61B17/12113 ,  A61B17/12181 ,  A61B2017/00004 ,  A61K31/4745 ,  A61K31/555 ,  A61K47/6927 ,  A61L24/0042 ,  A61L24/06 ,  A61L26/0014 ,  A61L26/0061 ,  A61L26/009 ,  A61L31/048 ,  A61L31/148 ,  A61L2300/204 ,  A61L2300/224 ,  A61L2400/06 ,  A61L2430/36 ,  C08F220/56 ,  C08F236/20 ,  C08L33/08 ,  C08L33/10 ,  C08L33/12 ,  C08L33/26

Abstract: Biodegradable, cross-linked polymer particle embolics and methods of making the same are described. The particle embolics can be used as embolization agents.

公开(公告)号：US09877731B2

公开(公告)日：2018-01-30

申请号：US15236135

申请日：2016-08-12

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael Constant ,  Terrance Tran ,  Joseph Gulachenski

IPC: A61M29/00 ,  A61B17/12 ,  A61L31/04 ,  A61L31/14 ,  A61L31/06 ,  A61L31/00

CPC classification number: A61B17/1219 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12154 ,  A61B17/12168 ,  A61L31/00 ,  A61L31/022 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/146 ,  A61L2400/04 ,  C08L71/02

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

公开(公告)号：US20160345978A1

公开(公告)日：2016-12-01

申请号：US15236135

申请日：2016-08-12

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Michael Constant ,  Terrance Tran ,  Joseph Gulachenski

IPC: A61B17/12 ,  A61L31/00 ,  A61L31/14 ,  A61L31/06

CPC classification number: A61B17/1219 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12145 ,  A61B17/12154 ,  A61B17/12168 ,  A61L31/00 ,  A61L31/022 ,  A61L31/041 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/145 ,  A61L31/146 ,  A61L2400/04 ,  C08L71/02

Abstract: Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.

Abstract translation: 用于闭塞体腔的装置，例如血管动脉瘤栓塞等，以及制造和使用这些装置的方法。 这些装置可以由新颖的膨胀材料，新颖的基础设施设计或两者组成。 所提供的设备是非常灵活的，并且能够对身体组织，导管，空腔等进行减少或不损坏的部署。

公开(公告)号：US20160279282A1

公开(公告)日：2016-09-29

申请号：US15081648

申请日：2016-03-25

Applicant: MicroVention, Inc.

Inventor： Gregory M. Cruise ,  Steve Plotkin ,  Xinping Wu

IPC: A61L24/06 ,  A61L24/00 ,  C08F222/38

CPC classification number: A61L24/06 ,  A61L24/001 ,  A61L2430/36 ,  C08F222/385 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26

Abstract: Embolic particles are described comprising a treated polymer particle. The particles are reaction products of a prepolymer solution including at least one polyether macromer and an appropriate monomer. The treated polymer particles can have a first diameter that is smaller than a second diameter, wherein the second diameter is achieved when the treated polymer particle is subjected to a physiological condition. Methods of making and using these polymer particles are also described.

Abstract translation: 描述包含经处理的聚合物颗粒的栓塞颗粒。 颗粒是包含至少一种聚醚大分子单体和合适单体的预聚物溶液的反应产物。 经处理的聚合物颗粒可以具有小于第二直径的第一直径，其中当经处理的聚合物颗粒经受生理条件时，实现第二直径。 还描述了制备和使用这些聚合物颗粒的方法。

公开(公告)号：US09381278B2

公开(公告)日：2016-07-05

申请号：US14661995

申请日：2015-03-18

Applicant: MicroVention, Inc.

Inventor： Michael Constant ,  Edward Michael Keeley ,  Joshua Garretson ,  Gregory M. Cruise

IPC: A61K9/00 ,  A61L31/04 ,  A61K49/04 ,  A61K49/12 ,  A61L31/14 ,  A61L31/18 ,  A61K47/34 ,  A61K47/30 ,  A61K51/12

CPC classification number: A61L31/048 ,  A61K9/0019 ,  A61K9/0024 ,  A61K47/30 ,  A61K47/34 ,  A61K49/0404 ,  A61K49/126 ,  A61K51/1213 ,  A61L31/145 ,  A61L31/18 ,  A61L2430/36 ,  Y10T428/298 ,  C08L33/26

Abstract: Described herein are apparatus, compositions, systems and methods for occluding vascular structures and vascular malformations with radiopaque hydrogel filaments. The filaments can contain no support members and can be CT and MR compatible. Methods of forming such filaments are also disclosed.