摘要:
Compounds having formula (I) or formula (II) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A, N, X, Y, R1, R2 and R3 are as defined in the specification. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.
摘要:
Compounds of formula (I) are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence, or bladder overactivity.
摘要:
The present invention relates to a method of treating disorders associated with the α2δ voltage-gated calcium channel ligand, comprising the administration of compounds of formula (I), or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof.
摘要:
In an embodiment of the disclosure, a separator utilized in a lithium battery is provided. The separator includes a non-woven polyester support, a porous layer of polyvinylidene fluoride (PVDF) or its derivatives formed on the non-woven polyester support, a layer of UV-curing or thermal-curing polymers formed on top of the porous layer of polyvinylidene fluoride (PVDF) or its derivatives.
摘要:
A method for manipulating a glass sheet compound shape during a severing operation including, for example, positioning a scoring device against the first side of the central portion of the glass sheet, and temporarily bending an extended portion of the glass sheet located between the scoring device and a selected one of the edge portions from a first orientation to a severing orientation by applying a force to the extended portion of the glass sheet. In one example, the force can be applied to achieve a predetermined surface stress in the glass sheet. The method can further include forming a score line along the first side of the central portion of the glass sheet while the force is being applied to the extended portion, and breaking away the selected one of the edge portions from the glass sheet along the score line.
摘要:
A limiting amplifier with an input stage with dc offset cancellation, identical gain stages, an output buffer and a feedback filter. The input stage receives a differential input signal and outputs a first intermediate differential signal. The gain stages are cascaded to amplify the first intermediate differential signal and generate a second intermediate differential signal, amplified by the output buffer to produce an output signal. The feedback filter provides a dc offset voltage of the output signal to the input stage for the dc offset cancellation. The input stage comprises a resistor network coupled between a pair of input nodes and a power line and comprising a common resistor, a pair of load resistors and a shunt resistor. The load resistors share a common terminal connected to the common resistor that is connected to the power line. The shunt resistor has two terminals respectively connected to the load resistors.
摘要:
The present invention discloses novel compounds of general formula (I) or a pharmaceutically acceptable salt or prodrug thereof (in which X1-X5, R5-R8b, Z1-Z2 and Ar1 are defined herein), a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain in mammals, and pharmaceutical compositions including those compounds and a process for making those compounds.
摘要:
A communication device is provided with a processing unit. The processing unit reads a plurality of elementary files from a single subscriber identity card for each of a plurality of subscriber numbers when power-on, and registers to a network for each of the subscriber numbers according to the read elementary files. Also, the processing unit enables a multi-standby mode of wireless communications in response to successful registration to the network for at least two of the subscriber numbers.
摘要:
Compounds of formula (I) wherein A, R1, R2, and R3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.
摘要:
A frequency synthesizer. The frequency synthesizer comprises a harmonic locked phase/frequency detector, a low pass filter, a voltage controlled oscillator, and a frequency divider. The harmonic locked phase/frequency detector receives a reference signal and a divided signal. The low pass filter is coupled to the harmonic locked phase/frequency detector. The voltage controlled oscillator is coupled to the low pass filter and provides an output signal. The frequency divider is coupled between the voltage controlled oscillator and the harmonic locked phase/frequency detector. Frequency of the divided signal is a harmonic frequency of the reference signal.