-
公开(公告)号：US07105644B2
公开(公告)日：2006-09-12
申请号：US09983802
申请日：2001-10-25
CPC分类号： C12N9/00 , A61K38/00 , C07K14/47 , G01N33/5008 , G01N33/5011 , G01N33/5041 , G01N33/5047 , G01N33/505 , G01N33/5058 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins. Disclosed embodiments of the invention also include antibodies that bind to secreted protein HHTLF25 and methods for making and using such antibodies.
摘要翻译： 本发明涉及新型人分泌蛋白质和含有编码这种蛋白质的编码区基因的分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。 本发明的公开的实施方案还包括结合分泌蛋白HHTLF25的抗体以及制备和使用该抗体的方法。
-
公开(公告)号：US07041802B2
公开(公告)日：2006-05-09
申请号：US10180454
申请日：2002-06-27
摘要： The present invention relates to three novel peptidoglycan recognition binding proteins expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A–B, FIGS. 2A–C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-c polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.
摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新的肽聚糖识别结合蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-c多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。
-
公开(公告)号：US07001992B2
公开(公告)日：2006-02-21
申请号：US10062831
申请日：2002-02-05
IPC分类号： C07K16/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
-
公开(公告)号：US06916786B2
公开(公告)日：2005-07-12
申请号：US10075446
申请日：2002-02-15
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/20 , C12N5/10
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
-
公开(公告)号：US06906178B2
公开(公告)日：2005-06-14
申请号：US10137316
申请日：2002-05-03
申请人： Paul E. Young , Steven M. Ruben
发明人： Paul E. Young , Steven M. Ruben
IPC分类号： C07K14/705 , C07K14/00 , C12P21/06
CPC分类号： C07K14/705
摘要： The present invention relates to vanilloid receptor-2, a novel member of the vanilloid receptor family. The invention provides isolated nucleic acid molecules encoding human VR2 receptors. VR2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of VR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of VR2 receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, chronic pain syndromes, congenital pain insensitivity, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.
摘要翻译： 本发明涉及香草素受体-2，其是香草素受体家族的新成员。 本发明提供编码人VR2受体的分离的核酸分子。 还提供VR2多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及鉴定VR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与VR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗疾病状态的治疗方法，包括但不限于慢性疼痛综合征，先天性疼痛不敏感性，炎症，缺血，宿主防御功能障碍，免疫监视功能障碍，关节炎，多发性硬化，自身免疫，免疫功能障碍和过敏。
-
公开(公告)号：US06849413B2
公开(公告)日：2005-02-01
申请号：US10068956
申请日：2002-02-11
申请人： Paul E. Young , Steven M. Ruben
发明人： Paul E. Young , Steven M. Ruben
IPC分类号： A01K67/027 , A61K38/00 , A61K39/395 , A61K48/00 , A61P37/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , G01N33/566 , G01N33/68 , G01N33/53
摘要： The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.
摘要翻译： 本发明涉及称为PGRP-L的新型人和鼠蛋白质，以及编码这些蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。
-
公开(公告)号：US06753164B2
公开(公告)日：2004-06-22
申请号：US09912628
申请日：2001-07-26
申请人： Jian Ni , Steven M. Ruben , Yanggu Shi
发明人： Jian Ni , Steven M. Ruben , Yanggu Shi
IPC分类号： C12N1512
CPC分类号： C07K14/8121 , A61K38/00
摘要： The present invention relates to novel human Serpin polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human Serpin polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human Serpin polypeptides.
摘要翻译： 本发明涉及新的人Serpin多肽和含有编码这些多肽的基因的编码区的分离的核酸。 还提供了用于产生人Serpin多肽的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人Serpin多肽相关的疾病的诊断和治疗方法。
-
98.发明授权Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) 失效使用人G蛋白趋化因子受体HDGNR10（CCR5）进行筛选的方法公开(公告)号：US06743594B1
公开(公告)日：2004-06-01
申请号：US09502784
申请日：2000-02-11
申请人： Yi Li , Steven M. Ruben
发明人： Yi Li , Steven M. Ruben
IPC分类号： G01N33567
CPC分类号： C07K14/7158 , A61K38/00 , C12N2799/026
摘要： Human G-protein chemokine receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein chemokine receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein chemokine receptor nucleic acid sequences and detecting a level of the soluble form of the receptors in a sample derived from a host.
摘要翻译： 公开了人G-蛋白趋化因子受体多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这些多肽来鉴定此类多肽的拮抗剂和激动剂的方法，以及分别在治疗上使用激动剂和拮抗剂治疗与G蛋白趋化因子受体多肽的低表达和过表达有关的病症的方法。 还公开了用于检测G蛋白趋化因子受体核酸序列中的突变并检测衍生自宿主的样品中受体的可溶形式的水平的诊断方法。
-
公开(公告)号：US06667032B2
公开(公告)日：2003-12-23
申请号：US09317641
申请日：1999-05-25
申请人： Jian Ni , Reiner L. Gentz , Steven M. Ruben
发明人： Jian Ni , Reiner L. Gentz , Steven M. Ruben
IPC分类号： A61K4500
CPC分类号： C07K14/54
摘要： The present invention concerns a novel T1R-like ligand II protein. In particular, isolated nucleic acid molecules are provided encoding the T1R-like ligand II protein. T1R-like ligand II polypeptides are also provided, as are recombinant vectors and host cells for expressing the same.
摘要翻译： 本发明涉及一种新的T1R样配体II蛋白。 特别地，提供编码T1R样配体II蛋白质的分离的核酸分子。 还提供了T1R样配体II多肽，重组载体和用于表达它们的宿主细胞也是如此。
-
公开(公告)号：US06649738B2
公开(公告)日：2003-11-18
申请号：US09902684
申请日：2001-07-12
申请人： Jian Ni , Reiner L. Gentz , Steven M. Ruben
发明人： Jian Ni , Reiner L. Gentz , Steven M. Ruben
IPC分类号： C07K100
CPC分类号： C07K14/81 , A61K38/00 , A61K48/00 , C07K14/8132 , C07K2319/00 , Y02A50/463
摘要： The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions, including breast cancer, and diagnostic methods for detecting pathologic disorders.
-
-
-
-
-
-
-
-
-
搜索结果
317 条记录 (耗时 0.086 秒)
