摘要:
Inhibitors of KIAA0175 are provided that reduce the expression or biological activities of KIAA0175, p53 and/or p21 in a mammalian cell. KIAA0175 inhibitors include anti-sense molecules, ribozymes, antibodies and antibody fragments, proteins and polypeptides as well as small molecules. KIAA0175 inhibitors find use in compositions and methods for decreasing KIAA0175, p53 and/or p21 gene expression as well as methods for increasing the chemo and/or radiosensitivity of mammalian cells, including tumor cells, methods for decreasing the side effects of cancer therapy and methods for treating neoplastic diseases.
摘要:
A motor drive and a choke therefor are disclosed, wherein the choke comprises a magnetic core with an inner leg and two outer legs, and four coils, which may be connected in DC current paths in the motor drive. First and second differential coils are wound around first and second outer legs, respectively; and first and second common-mode coils are wound around the inner leg of the choke. The first and second differential coils smooth the DC current on a DC bus in the motor drive, and the first and second common-mode coils suppress common-mode voltages in the motor drive. Also disclosed is a method for suppressing common-mode voltages in a motor drive.
摘要:
A detector compares a first bit of a bit stream to a first bit of a pattern. If the first bit of the bit stream and the first bit of the pattern are the same, another detector is allowed to read a second bit of the bit stream and compare it to a second bit of the pattern. This continues until all bits of the pattern are detected. By performing the comparison as each bit of the bit stream arrives on a node, the present detectors are able to detect bit patterns in high-speed bit streams.
摘要:
A method and a circuit detect the presence of a high-speed signal, such as a high-speed differential signal, based on a software-programmable signal amplitude threshold. In one embodiment, when the amplitude threshold is exceeded, a current is generated to charge a capacitor. The voltage on the capacitor is compared to a second pre-set voltage in a low-speed comparator, which provides an output voltage indicating detection of the high-speed signal.
摘要:
A PWM based converter including a Y-.DELTA., Y--Y transformer (or a .DELTA.--.DELTA., .DELTA.-Y transformer) wherein the Y-.DELTA. portion of the transformer phase shifts input voltage by 30.degree. with respect to the Y--Y portion of the transformer and thereby eliminates many low order supply line harmonics. The rectifier also includes two series connected PWM switching rectifiers, one rectifier receiving input voltages from the Y--Y portion of the transformer and the other rectifier receiving input voltages from the Y-.DELTA. portion of the transformer, and a controller for controlling the first and second rectifiers so as to eliminate low order harmonics on the supply lines that are not eliminated by the transformer. A capacitive bank is required between each rectifier and the transformer.
摘要:
Methods and charging apparatus are presented for charging cell capacitors of a multilevel power conversion system, in which an auxiliary charging source is selectively applied across DC bus terminals while one or more selected multilevel converter cells are alternately switched between a first state to bypass the selected cell or cells and a second state to charge the cell capacitor or capacitors of the selected cell via charging current from the auxiliary charging source.
摘要:
The invention relates to bicyclic compounds of formulas I and Ia, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要:
The invention relates to bicyclic compounds of formulas I and I′, and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
摘要:
The invention relates to bicyclic compounds of formula (1′), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.