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103 条记录 (耗时 0.121 秒)

    Methods of populating data structures for use in evolutionary simulations
    91.
    发明授权
    Methods of populating data structures for use in evolutionary simulations 失效
    填充用于进化模拟的数据结构的方法

    公开(公告)号：US07430477B2

    公开(公告)日：2008-09-30

    申请号：US11210239

    申请日：2005-08-22

    申请人： Sergey A. Selifonov ,  Willem P. C. Stemmer

    发明人： Sergey A. Selifonov ,  Willem P. C. Stemmer

    IPC分类号： G01N33/48 ,  C12Q1/68

    CPC分类号： G06N3/126 ,  G06F19/14 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

    摘要： In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more a biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.

    摘要翻译： 特别地，本发明提供了用于进化建模的填充数据结构的新颖方法。 特别地，本发明提供了用多个字符串填充数据结构的方法。 所述方法包括将两个或多个生物分子编码成字符串以提供两个或多个不同的初始字符串的集合; 从字符串池中选择至少两个子字符串; 连接子串以形成与一个或多个初始字符串相同长度的一个或多个产品串; 将产品字符串添加到字符串集合中; 并且可选地使用一个或多个产品串将该过程重复为初始字符串的集合中的初始字符串。

    Methods of populating data structures for use in evolutionary simulations
    94.
    发明授权
    Methods of populating data structures for use in evolutionary simulations 有权
    填充用于进化模拟的数据结构的方法

    公开(公告)号：US06961664B2

    公开(公告)日：2005-11-01

    申请号：US09495668

    申请日：2000-02-01

    申请人： Sergey A. Selifonov ,  Willem P. C. Stemmer

    发明人： Sergey A. Selifonov ,  Willem P. C. Stemmer

    IPC分类号： A61K39/00 ,  C07K14/16 ,  C07K14/505 ,  C07K14/535 ,  C12N9/16 ,  C12N15/10 ,  C12N15/11 ,  G06F19/00 ,  G01N33/48 ,  C07H21/02 ,  C12Q1/68 ,  G01N31/00

    CPC分类号： C12N15/11 ,  A61K39/00 ,  C07K14/005 ,  C07K14/505 ,  C07K14/535 ,  C12N9/16 ,  C12N15/1027 ,  C12N2740/16122

    摘要： In particular, this invention provides novel methods of populating data structures for use in evolutionary modeling. In particular, this invention provides methods of populating a data structure with a plurality of character strings. The methods involve encoding two or more a biological molecules into character strings to provide a collection of two or more different initial character strings; selecting at least two substrings from the pool of character strings; concatenating the substrings to form one or more product strings about the same length as one or more of the initial character strings; adding the product strings to a collection of strings; and optionally repeating this process using one or more of the product strings as an initial string in the collection of initial character strings.

    摘要翻译： 特别地，本发明提供了用于进化建模的填充数据结构的新颖方法。 特别地，本发明提供了用多个字符串填充数据结构的方法。 所述方法包括将两个或多个生物分子编码成字符串以提供两个或多个不同的初始字符串的集合; 从字符串池中选择至少两个子字符串; 连接子串以形成与一个或多个初始字符串相同长度的一个或多个产品串; 将产品字符串添加到字符串集合中; 并且可选地使用一个或多个产品串将该过程重复为初始字符串的集合中的初始字符串。

    Evolving susceptibility of cellular receptors to viral infection by recursive recombination
    98.
    发明授权
    Evolving susceptibility of cellular receptors to viral infection by recursive recombination 失效
    细胞受体对递归重组病毒感染的易感性

    公开(公告)号：US06482647B1

    公开(公告)日：2002-11-19

    申请号：US09724067

    申请日：2000-11-28

    申请人： Willem P. C. Stemmer

    发明人： Willem P. C. Stemmer

    IPC分类号： C12N1500

    CPC分类号： C12N15/1058 ,  C12N15/1027 ,  C12N15/1034 ,  C12N15/52 ,  C12N15/64

    摘要： The invention provides a number of strategies for transferring and/or evolving gene(s) associated with cellular DNA uptake so that they confer or enhance DNA-uptake capacity of a recipient cell. Evolution is achieved by recursive cycles of recombination and screening/selection. One such strategy entails evolving genes that confer competence in one species to confer either greater competence in that species, or comparable or greater competence in a second species. Another strategy entails evolving genes for use as components of cloning vector to confer enhanced uptake of the vector. Other strategies entail evolving viral receptors, viruses, and genes that mediate conjugal transfer.

    摘要翻译： 本发明提供了用于转移和/或发展与细胞DNA摄取相关的基因的许多策略，使得它们赋予或增强受体细胞的DNA吸收能力。 通过重组和筛选/选择的递归周期来实现进化。 一种这样的策略需要演变基因，赋予一种物种的能力，以赋予该物种更大的能力，或者在第二种物种中具有相当或更大的能力。 另一种策略需要进化基因，用作克隆载体的组分以赋予载体增强的摄取。 其他策略需要发展介导共轭转移的病毒感受器，病毒和基因。