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91.发明申请PATIENT STATE DETECTION BASED ON SUPERVISED MACHINE LEARNING BASED ALGORITHM 审中-公开基于监督机器学习算法的患者状态检测公开(公告)号：US20100280335A1
公开(公告)日：2010-11-04
申请号：US12694044
申请日：2010-01-26
CPC分类号： A61N1/36082 , G06F2221/2101 , G06F2221/2105 , G06K9/6268 , G06N20/00 , G16H50/50
摘要： A patient state is detected with at least one classification boundary generated by a supervised machine learning technique, such as a support vector machine. In some examples, the patient state detection is used to at least one of control the delivery of therapy to a patient, to generate a patient notification, to initiate data recording, or to evaluate a patient condition. In addition, an evaluation metric can be determined based on a feature vector, which is determined based on characteristics of a patient parameter signal, and the classification boundary. Example evaluation metrics can be based on a distance between at least one feature vector and the classification boundary and/or a trajectory of a plurality of feature vectors relative to the classification boundary over time.
摘要翻译： 用监督机器学习技术（例如支持向量机）生成的至少一个分类边界来检测病人状态。 在一些示例中，患者状态检测用于控制对患者的治疗递送，产生患者通知，开始数据记录或评估患者状况中的至少一个。 此外，可以基于基于患者参数信号的特性确定的特征向量和分类边界来确定评估度量。 示例评估度量可以基于至少一个特征向量与分类边界之间的距离和/或相对于分类边界随时间的多个特征向量的轨迹。
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公开(公告)号：US20100256710A1
公开(公告)日：2010-10-07
申请号：US12418291
申请日：2009-04-03
CPC分类号： A61N1/3787 , H02J7/025 , H02J50/10
摘要： A charging system is disclosed. In one embodiment, the system includes a charging unit having a primary coil, and an implantable medical device comprising a secondary coil to receive charge from the primary coil. The implantable medical device further includes a half-wave voltage-doubling rectifier coupled to the secondary coil, a full-wave rectifier coupled to the secondary coil, and a rechargeable power source. Control logic is provided to periodically configure the rechargeable power source to receive charge from a selected one of the voltage-doubling circuit and the full-wave rectifier in a manner that increases rate at which charge is transferred from the secondary coil to the rechargeable power source. The control logic may configure the rechargeable power source to receive charge based on one or more monitored conditions which may include, for example, an indication of a current, a voltage, a coupling coefficient, back-scatter, and temperature.
摘要翻译： 公开了一种充电系统。 在一个实施例中，系统包括具有初级线圈的充电单元和包括用于接收来自初级线圈的电荷的次级线圈的可植入医疗装置。 可植入医疗装置还包括耦合到次级线圈的半波倍压整流器，耦合到次级线圈的全波整流器和可再充电电源。 提供控制逻辑以周期性地配置可再充电电源，以便以增加电荷从次级线圈传递到可再充电电源的速率的方式从所选倍压电路和全波整流器中接收电荷 。 控制逻辑可以配置可再充电电源以基于一个或多个监视的条件来接收电荷，这些状态可以包括例如电流，电压，耦合系数，反向散射和温度的指示。
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公开(公告)号：US07714757B2
公开(公告)日：2010-05-11
申请号：US11861939
申请日：2007-09-26
IPC分类号： H03M3/00
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper-stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译： 本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。 斩波稳定的ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。 通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。 以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。
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公开(公告)号：US20090105785A1
公开(公告)日：2009-04-23
申请号：US12238025
申请日：2008-09-25
IPC分类号： A61N1/02 , A61B5/00 , A61B5/0476 , G08B21/00 , A61M31/00 , A61B5/0488
CPC分类号： A61N1/36542 , A61N1/36132 , A61N1/36135 , A61N1/37 , G06F19/00 , G06F19/3481
摘要： A therapy program is selected based on a patient state, where the patient state comprises at least one of a movement state, sleep state or speech state. In this way, therapy delivery is tailored to the patient state, which may include specific patient symptoms. The therapy program is selected from a plurality of stored therapy programs that comprise therapy programs associated with a respective one at least two of the movement, sleep, and speech states. Techniques for determining a patient state include receiving volitional patient input or detecting biosignals generated within the patient's brain. The biosignals are nonsymptomatic and may be incidental to the movement, sleep, and speech states or generated in response to volitional patient input.
摘要翻译： 基于患者状态选择治疗程序，其中患者状态包括运动状态，睡眠状态或语音状态中的至少一个。 以这种方式，治疗递送是针对患者状态而定制的，其可以包括特定的患者症状。 治疗程序选自包括与运动，睡眠和言语状态中的至少两个相关的治疗程序的多个存储的治疗程序。 用于确定患者状态的技术包括接收患者输入或检测患者大脑内生成的生物信号。 生物信号是无症状的，可能与运动，睡眠和言语状态有关，或者是响应于患者输入的意图产生的。
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公开(公告)号：US20090099627A1
公开(公告)日：2009-04-16
申请号：US12237799
申请日：2008-09-25
申请人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
发明人： Gregory F. Molnar , Steven S. Gill , Keith A. Miesel , Mark S. Lent , Timothy J. Denison , Eric J. Panken , Carl D. Wahlstrand , Jonathan C. Werder
IPC分类号： A61N1/36 , A61B5/0476 , A61M37/00
CPC分类号： A61B5/04014 , A61B5/0006 , A61B5/4082 , A61B5/6814 , A61N1/36003 , A61N1/36014 , A61N1/36025 , A61N1/36067 , A61N1/36082
摘要： A movement state of a patient is detected based on brain signals, such as an electroencephalogram (EEG) signal. In some examples, a brain signal within a dorsal-lateral prefrontal cortex of a brain of the patient indicative of prospective movement of the patient may be sensed in order to detect the movement state. The movement state may include the brain state that indicates the patient is intending on initiating movement, initiating movement, attempting to initiate movement or is actually moving. In some examples, upon detecting the movement state, a movement disorder therapy is delivered to the patient. In some examples, the therapy delivery is deactivated upon detecting the patient is no longer in a movement state or that the patient has successfully initiated movement. In addition, in some examples, the movement state detected based on the brain signals may be confirmed based on a signal from a motion sensor.
摘要翻译： 基于诸如脑电图（EEG）信号的脑信号检测患者的运动状态。 在一些示例中，可以检测指示患者的预期运动的患者的脑的背侧前额叶皮层内的脑信号，以便检测运动状态。 运动状态可以包括指示患者打算启动运动，启动运动，尝试启动运动或实际运动的脑状态。 在一些示例中，在检测到运动状态时，将运动障碍治疗递送给患者。 在一些示例中，在检测到患者不再处于运动状态或患者已经成功启动运动时，治疗递送被停用。 此外，在一些示例中，可以基于来自运动传感器的信号来确认基于脑信号检测到的运动状态。
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公开(公告)号：US20090079607A1
公开(公告)日：2009-03-26
申请号：US11861939
申请日：2007-09-26
CPC分类号： A61B5/7203 , A61B5/04012 , A61B5/7217 , A61B5/7228 , A61B5/7242 , H03M3/34 , H03M3/39
摘要： This disclosure describes a chopper-stabilized sigma-delta analog-to-digital converter (ADC). The ADC is configured to provide accurate output at low frequency with relatively low power. The chopper-stabilized ADC substantially reduces or eliminates noise and offset from an output signal produced by the mixer amplifier. Dynamic limitations, i.e., glitching that result from chopper stabilization at low power are substantially eliminated or reduced through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the ADC operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. In this manner, the chopper-stabilized ADC can be used in a low power system, such as an implantable medical device (IMD), to provide a stable, low-noise output signal.
摘要翻译： 本公开描述了斩波稳定的Σ-Δ模数转换器（ADC）。 ADC配置为以较低功率提供低频精确输出。 斩波稳定的ADC大大减少或消除了由混频放大器产生的输出信号的噪声和偏移。 通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除或减少动态限制，即，在低功率下由斩波器稳定产生的啁啾。 ADC的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或进入信号通道的外部信号的最小混叠。 以这种方式，斩波稳定的ADC可以用在诸如可植入医疗设备（IMD）的低功率系统中，以提供稳定的低噪声输出信号。
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公开(公告)号：US06627067B1
公开(公告)日：2003-09-30
申请号：US09602650
申请日：2000-06-22
IPC分类号： G01N27327
CPC分类号： C12Q1/6869 , B01L3/5027 , B24B37/013 , G01N33/48721 , H01L22/26 , H01L2924/0002 , H01L2924/00 , C12Q2523/305 , C12Q2565/607 , C12Q2565/631
摘要： A method for evaluating a polymer molecule including linearly connected monomer residues includes providing a polymer molecule in a liquid, contacting the liquid with an insulating solid-state membrane having a detector capable of detecting polymer molecule characteristics, and causing the polymer molecule to traverse a limited region of the solid-state membrane so that monomers of the polymer molecule traverse the limit region in sequential order, whereby the polymer molecule interacts linearly with the detector and data suitable to determine polymer molecule characteristics are obtained. The limited region may be defined by a nanometer-sized aperture in the membrane.
摘要翻译： 包括线性连接的单体残基的聚合物分子的评估方法包括在液体中提供聚合物分子，使液体与具有能够检测聚合物分子特性的检测器的绝缘固态膜接触，并使聚合物分子穿过有限的 区域，使得聚合物分子的单体按顺序横穿极限区域，由此聚合物分子与检测器线性相互作用，并获得适合于确定聚合物分子特性的数据。 有限区域可以由膜中的纳米尺寸的孔限定。
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98.发明授权Differential parametric amplifier with physically-coupled electrically-isolated micromachined structures 有权具有物理耦合电隔离微加工结构的差分参数放大器公开(公告)号：US06611168B1
公开(公告)日：2003-08-26
申请号：US10024741
申请日：2001-12-19
IPC分类号： H03F700
CPC分类号： H01G5/16 , H03F3/38 , H03F7/04 , H03F2200/261
摘要： A micromachined variable capacitor structure is used as a modulation mechanism for a differential parametric amplifier. The capacitance of the capacitor structure is modulated by a control signal while a differential signal is applied to the capacitor structure. Modulation of the capacitance produces a signal representative of the input differential voltage. This signal is provided to an amplifier. Once the signal is amplified, a demodulator demodulates the amplified signal to provide an amplified version of the differential signal. The variable capacitor structure also allows for internal feedback, which permits the parametric amplifier to be used as a galvanically isolated differential measurement amplifier. A number of techniques are used to remove common mode and other errors from the modulated difference signal, thereby eliminating them from the amplified output.
摘要翻译： 微机械可变电容器结构用作微分参量放大器的调制机制。 电容器结构的电容由控制信号调制，同时将差分信号施加到电容器结构。 电容的调制产生代表输入差分电压的信号。 该信号被提供给放大器。 一旦信号被放大，解调器解调放大的信号以提供差分信号的放大版本。 可变电容器结构还允许内部反馈，这允许参数放大器用作电隔离差分测量放大器。 许多技术用于从调制的差分信号中去除共模和其他误差，从而从放大的输出中消除它们。
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