公开(公告)号：US09681798B2

公开(公告)日：2017-06-20

申请号：US14933666

申请日：2015-11-05

申请人： Ian W. Hunter ,  Yi Chen

发明人： Ian W. Hunter ,  Yi Chen

IPC分类号： A61B1/06 ,  G01J3/45 ,  G01J3/28 ,  G01J3/02 ,  G01J3/12 ,  G01J3/453

CPC分类号： A61B1/0638 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/45 ,  G01J3/453 ,  G01J3/4535

摘要： Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging spectrometer includes an integrated position sensing array that measures the relative positions of the interferometer components based on an interference pattern generated by illuminating the interferometer with a reference beam. Such an imaging spectrometer includes a processor that controls the interferometer component position by actuating a voice coil and several piezo-electric elements to align the components with respect to each other and to provide a desired optical path length mismatch between the interferometer arms. In some cases, the processor may use feedback and feed forward control, possibly based on the actuators' transfer functions, for more precise positioning. The processor may also implement adaptive and recursive spectral sampling to reduce the image acquisition period.

公开(公告)号：US09546197B2

公开(公告)日：2017-01-17

申请号：US13982797

申请日：2012-01-31

申请人： Shidong Liu ,  Zhaoli Zhang ,  Yi Chen ,  Xiusheng Wang ,  Liangliang Zhou ,  Xiaoming Ji

发明人： Shidong Liu ,  Zhaoli Zhang ,  Yi Chen ,  Xiusheng Wang ,  Liangliang Zhou ,  Xiaoming Ji

IPC分类号： C07K7/54 ,  C07K7/56 ,  C12N1/14 ,  C12R1/645 ,  C12P7/64

CPC分类号： C07K7/54 ,  C07K7/56 ,  C12N1/14 ,  C12P7/64 ,  C12R1/645

摘要： Provided is a method for preparing a compound represented by Formula I or a salt thereof, wherein Coleophoma empetri F-11899 (FERM BP2635) and/or a mutant strain thereof is cultured in a medium containing amino acid or a salt thereof, an insoluble organic source, and a sugar alcohol, to produce the compound of Formula I or a salt thereof.

摘要翻译： 本发明提供了制备式I化合物或其盐的方法，其中，在含有氨基酸或其盐的培养基中培养含有绒毛母细胞F-11899（FERM BP2635）和/或其突变株的不溶性有机物 来源和糖醇，以制备式I化合物或其盐。

公开(公告)号：US09376395B2

公开(公告)日：2016-06-28

申请号：US14345562

申请日：2012-09-14

申请人： Yu Chen ,  Lan Yang ,  Feiyu Feng ,  Qiufu Ge ,  Dianwu Guo ,  Yi Chen

发明人： Yu Chen ,  Lan Yang ,  Feiyu Feng ,  Qiufu Ge ,  Dianwu Guo ,  Yi Chen

IPC分类号： C07D235/16 ,  A61K47/40 ,  A61K31/16 ,  A61K31/4184 ,  A61K9/00 ,  A61K9/19 ,  A61K47/48

CPC分类号： C07D235/16 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/16 ,  A61K31/4184 ,  A61K47/40 ,  A61K47/6951 ,  Y02A50/414

摘要： The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X1, X2, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.

摘要翻译： 本发明涉及药物组合物，其包含：（a）环多糖和（b）式（I）化合物或其药学上可接受的盐：其中X 1，X 2，Q，Z和m如本文所定义。 还公开了用这些组合物治疗肿瘤疾病或免疫疾病的方法。

公开(公告)号：US09265461B2

公开(公告)日：2016-02-23

申请号：US12872643

申请日：2010-08-31

申请人： Ian W. Hunter ,  Yi Chen ,  Lynette A. Jones ,  N. Catherine Hogan

发明人： Ian W. Hunter ,  Yi Chen ,  Lynette A. Jones ,  N. Catherine Hogan

IPC分类号： A61B5/103 ,  A61B9/00 ,  A61B5/00

CPC分类号： A61B5/442 ,  A61B5/0048 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/0055 ,  A61B5/0057 ,  A61B5/441 ,  A61B5/6824 ,  A61B9/00

摘要： A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin, repeating the measurement of the mechanical property after the application of the product, and comparing the before and after measurements to quantify the effect of the product.Measuring the mechanical property of the skin can include placing a probe against a surface of the skin, perturbing the skin with the probe using a stochastic sequence, and measuring the response of the skin to the perturbation. Perturbing the skin can include indenting the skin with the probe, extending the skin with the probe, and sliding the probe across the skin surface. The mechanical property may be indicative of skin compliance, skin elasticity, skin stiffness, or skin damping. The mechanical property can be dependent on perturbation depth and may be measured at a plurality of anatomical locations.

摘要翻译： 用于测试皮肤护理产品的效果的方法包括使用非线性随机系统识别来测量皮肤组织的机械性质，将产品施用于皮肤，重复产品施用后的机械性能的测量，并比较之前 并经过测量以量化产品的影响。 测量皮肤的机械性能可以包括将探针放置在皮肤表面上，使用随机序列用探针扰动皮肤，以及测量皮肤对扰动的反应。 刺激皮肤可以包括使用探针压伤皮肤，用探头延伸皮肤，并将探头滑过皮肤表面。 机械性能可以指示皮肤顺应性，皮肤弹性，皮肤刚度或皮肤阻滞。 机械性能可以取决于扰动深度，并且可以在多个解剖位置处测量。

公开(公告)号：US20150011830A1

公开(公告)日：2015-01-08

申请号：US14355490

申请日：2011-08-25

申请人： Ian W. Hunter ,  Yi Chen ,  Jillian M. Oliveira

发明人： Ian W. Hunter ,  Yi Chen ,  Jillian M. Oliveira

IPC分类号： A61B1/00 ,  A61B1/005

CPC分类号： A61B1/0016 ,  A61B1/0052 ,  A61B1/0055

摘要： The present invention relates to an endoscope having a motorized assembly to control the distal end of an endoscope. Preferred embodiments can include disposable and reusable components. The system reduces the force need to control the tip of the endoscope and thereby reduce the risk of perforation′.

摘要翻译： 本发明涉及一种具有控制内窥镜前端的机动组件的内窥镜。 优选实施例可以包括一次性和可重复使用的部件。 该系统减少了控制内窥镜尖端的力量，从而降低了穿孔的风险。

公开(公告)号：US20140067246A1

公开(公告)日：2014-03-06

申请号：US13600398

申请日：2012-08-31

申请人： David A. Eldredge ,  Yi Chen ,  Jerob Svidunovich ,  Timothy Robert Brown ,  John W. Mcelroy

发明人： David A. Eldredge ,  Yi Chen ,  Jerob Svidunovich ,  Timothy Robert Brown ,  John W. Mcelroy

IPC分类号： G06F7/00

CPC分类号： B61L3/006 ,  B60L2200/26 ,  B61L15/0027 ,  B61L27/0022 ,  B61L27/0027

摘要： A system includes a vehicle control module, an operating information module, and a fuel analysis module. The vehicle control module is configured to obtain a trip plan for the vehicle. The operating information module is configured to be disposed on-board the vehicle and to autonomously obtain operating information describing one or more of tractive events or braking events performed during the trip. The fuel analysis module is configured to be disposed on-board the vehicle, to receive the operating information from the operating information module, and to autonomously determine a fuel consumption for at least a portion of the trip using the operating information received from the operating information module.

摘要翻译： 一种系统包括车辆控制模块，操作信息模块和燃料分析模块。 车辆控制模块被配置为获得车辆的行程计划。 操作信息模块被配置为布置在车辆上并且自主地获得描述在行程期间执行的牵引事件或制动事件中的一个或多个的操作信息。 燃料分析模块被配置为布置在车辆上，以从操作信息模块接收操作信息，并且使用从操作信息接收的操作信息自主地确定行程的至少一部分的燃料消耗 模块。

公开(公告)号：US08515939B2

公开(公告)日：2013-08-20

申请号：US12296490

申请日：2007-04-10

申请人： Yi Chen ,  Yuliang He

发明人： Yi Chen ,  Yuliang He

IPC分类号： G06F17/30

CPC分类号： G06F17/2785 ,  G06F17/2247

摘要： A system for facilitating rule-based content mining to extract content from structured or unstructured data receives a file that contains structured or unstructured data, or a mixture of both. The system then generates a processable extensible markup language (pXML) file based on the received file. The system further extracts content from the pXML file based on one or more rules and generates a semantic XML file based on a specified format.

摘要翻译： 用于促进基于规则的内容挖掘以从结构化或非结构化数据提取内容的系统接收包含结构化或非结构化数据的文件，或两者的混合。 然后，系统基于接收到的文件生成可执行的可扩展标记语言（pXML）文件。 该系统基于一个或多个规则进一步从pXML文件中提取内容，并基于指定的格式生成语义XML文件。

公开(公告)号：US08324398B2

公开(公告)日：2012-12-04

申请号：US10566150

申请日：2004-07-28

申请人： Yusheng Wu ,  Shili Chen ,  Yi Chen ,  Roger Hanselmann ,  Rongliang Lou ,  Jiacheng Zhou

发明人： Yusheng Wu ,  Shili Chen ,  Yi Chen ,  Roger Hanselmann ,  Rongliang Lou ,  Jiacheng Zhou

IPC分类号： C07D263/20

CPC分类号： C07D263/20 ,  C07D263/32 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D473/00 ,  C07D487/04

摘要： The present invention relates to processes for the preparation of biaryl oxazolidinones. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

摘要翻译： 本发明涉及制备联芳基恶唑烷酮的方法。 这些化合物可用作抗感染，抗增殖，抗炎和促动力。

公开(公告)号：US08183259B2

公开(公告)日：2012-05-22

申请号：US13187154

申请日：2011-07-20

申请人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

发明人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC分类号： A61K31/47

CPC分类号： C07D401/12 ,  C07D401/14

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状 包括但不限于白血病，如急性骨髓性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD）慢性骨髓性白血病（MPD），介导，依赖或与p110δ活性相关的癌症的方法 （CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。

公开(公告)号：US08183258B2

公开(公告)日：2012-05-22

申请号：US13187135

申请日：2011-07-20

申请人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

发明人： Yi Chen ,  Timothy D. Cushing ,  Xiaolin Hao ,  Xiao He ,  Andreas Reichelt ,  Robert M. Rzasa ,  Jennifer Seganish ,  Youngsook Shin ,  Dawei Zhang

IPC分类号： A61K31/47

CPC分类号： C07D401/12 ,  C07D401/14

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 取代的双环杂芳基和含有它们的组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎症性或不稳定性膀胱病，牛皮癣，皮肤炎症成分的投诉，慢性炎性病症 不限于自身免疫性疾病如系统性红斑狼疮（SLE），重症肌无力，类风湿关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，Sjoegren综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏症状。 本发明还使得能够治疗依赖于p110δ活性或与p110δ活性相关的癌症的方法，包括但不限于白血病，例如急性骨髓性白血病（AML）Myelo-dysplastic综合征（MDS）骨髓增殖性疾病（MPD） 慢性骨髓性白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤如乳腺癌。